{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:NGRKVCBUMBYIYI74TSVMMFB33N","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9c904bb596a54c98dea678c35b71a38532149e29d3f2e514812c33a09ab7143c","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2024-06-27T11:40:13Z","title_canon_sha256":"f675a01d171c39516795dc7ecf290288afe9f6b56b5f5e5ac8f80ade03fb1fc5"},"schema_version":"1.0","source":{"id":"2406.19109","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2406.19109","created_at":"2026-07-05T10:35:34Z"},{"alias_kind":"arxiv_version","alias_value":"2406.19109v2","created_at":"2026-07-05T10:35:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2406.19109","created_at":"2026-07-05T10:35:34Z"},{"alias_kind":"pith_short_12","alias_value":"NGRKVCBUMBYI","created_at":"2026-07-05T10:35:34Z"},{"alias_kind":"pith_short_16","alias_value":"NGRKVCBUMBYIYI74","created_at":"2026-07-05T10:35:34Z"},{"alias_kind":"pith_short_8","alias_value":"NGRKVCBU","created_at":"2026-07-05T10:35:34Z"}],"graph_snapshots":[{"event_id":"sha256:8b72e21067cff57c17f067f0edff0dc626f5d42513d402080f8316a570bcf0fa","target":"graph","created_at":"2026-07-05T10:35:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2406.19109/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Mathematical models of gene regulatory networks are widely used to study cell fate changes and transcriptional regulation. When designing such models, it is important to accurately account for sources of stochasticity. However, doing so can be computationally expensive and analytically untractable, posing limits on the extent of our explorations and on parameter inference. Here, we explore this challenge using the example of a simple auto-negative feedback motif, in which we incorporate stochastic variation due to transcriptional bursting and noise from finite copy numbers. We find that transc","authors_text":"Antoine Moneyron, Jochen Kursawe, Tobias Galla","cross_cats":["physics.bio-ph","q-bio.SC"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2024-06-27T11:40:13Z","title":"Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2406.19109","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cdc98d60fe4eede45689ccfcb7c6379277b06b5a90a65522e813f638430178ce","target":"record","created_at":"2026-07-05T10:35:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9c904bb596a54c98dea678c35b71a38532149e29d3f2e514812c33a09ab7143c","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2024-06-27T11:40:13Z","title_canon_sha256":"f675a01d171c39516795dc7ecf290288afe9f6b56b5f5e5ac8f80ade03fb1fc5"},"schema_version":"1.0","source":{"id":"2406.19109","kind":"arxiv","version":2}},"canonical_sha256":"69a2aa883460708c23fc9caac6143bdb4e605394ea104def8db3ad9780e919db","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"69a2aa883460708c23fc9caac6143bdb4e605394ea104def8db3ad9780e919db","first_computed_at":"2026-07-05T10:35:34.035770Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:35:34.035770Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uH11t4n+mgk9lK9ek84Fdh7Fs4DyUkr39RUIoxk+y9lodJdIZZBSr7LZ3uh4jvnwG6DSv9zUSIT+PrnFsAOMDA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:35:34.036249Z","signed_message":"canonical_sha256_bytes"},"source_id":"2406.19109","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cdc98d60fe4eede45689ccfcb7c6379277b06b5a90a65522e813f638430178ce","sha256:8b72e21067cff57c17f067f0edff0dc626f5d42513d402080f8316a570bcf0fa"],"state_sha256":"7ac4137f41c8e1fbbfacf07c616f5f34018097369461911f2a495a6063bc4905"}