{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:NKJISCYS5Z6YDISRG4TIRSA6KM","short_pith_number":"pith:NKJISCYS","canonical_record":{"source":{"id":"1312.7532","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-12-29T13:04:05Z","cross_cats_sorted":[],"title_canon_sha256":"18578addacfd57afcbf2cdf82fd9c8aa8666a3332f5c65859da597d991ddb433","abstract_canon_sha256":"b564dfa8abc8efcf7fe03c96f2e90dacbbcffc7f827ec8270f3772ea8a3e2f13"},"schema_version":"1.0"},"canonical_sha256":"6a92890b12ee7d81a251372688c81e533873758d89ce44230474d574a0170abc","source":{"kind":"arxiv","id":"1312.7532","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1312.7532","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"arxiv_version","alias_value":"1312.7532v1","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1312.7532","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"pith_short_12","alias_value":"NKJISCYS5Z6Y","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_16","alias_value":"NKJISCYS5Z6YDISR","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_8","alias_value":"NKJISCYS","created_at":"2026-05-18T12:27:52Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:NKJISCYS5Z6YDISRG4TIRSA6KM","target":"record","payload":{"canonical_record":{"source":{"id":"1312.7532","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-12-29T13:04:05Z","cross_cats_sorted":[],"title_canon_sha256":"18578addacfd57afcbf2cdf82fd9c8aa8666a3332f5c65859da597d991ddb433","abstract_canon_sha256":"b564dfa8abc8efcf7fe03c96f2e90dacbbcffc7f827ec8270f3772ea8a3e2f13"},"schema_version":"1.0"},"canonical_sha256":"6a92890b12ee7d81a251372688c81e533873758d89ce44230474d574a0170abc","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:03:43.141438Z","signature_b64":"bKlGIg/JJV1QA3DdBMWZ/iUZZRy4OA2Z+Vi6OT3/mrGKAFVmFo2nbtu8Rx3cqn/yA7tPT/kSxzfPj2q/kAzhBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6a92890b12ee7d81a251372688c81e533873758d89ce44230474d574a0170abc","last_reissued_at":"2026-05-18T03:03:43.140628Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:03:43.140628Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1312.7532","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:03:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3oRSh7Omf22NZgIS4JHxQrz3JVs/dJE6TTT2sKTdBd3MCt2iel+k6Su305742IgJbW5/6MuKpkWORPbwDPjRDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-19T21:57:33.284989Z"},"content_sha256":"f05c0c1cdbbfac52a18fc5dbd6d09b769850957ae99536e8055e1d52f95acadb","schema_version":"1.0","event_id":"sha256:f05c0c1cdbbfac52a18fc5dbd6d09b769850957ae99536e8055e1d52f95acadb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:NKJISCYS5Z6YDISRG4TIRSA6KM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Detection of the melanoma biomarker TROY using silicon nanowire field-effect transistors","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Carsten Maedler, Daniel Kim, Mi Hong, Pritiraj Mohanty, Remco A. Spanjaard, Shyamsunder Erramilli","submitted_at":"2013-12-29T13:04:05Z","abstract_excerpt":"Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods. One example where accurate measurement of small concentrations is necessary is detection of serum biomarkers, such as the recently discovered tumor necrosis factor receptor superfamily member TROY (TNFRSF19), which may serve as a biomarker for melanoma. TROY is normally only present in brain but it is aberrantly expressed in primary and metastatic melanoma cells and shed"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1312.7532","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:03:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iFKGdiI7zcUkypD89177F4nZsNRogch7lS3xEugl65GaErjLh54s2NExexOaPYaS/6Rpg+PP95YbI7IZIb3/BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-19T21:57:33.285345Z"},"content_sha256":"610eac7f30e0817cc8dcfd3eff9c80341f69a7bc55cafd44dd357704bfc49cc7","schema_version":"1.0","event_id":"sha256:610eac7f30e0817cc8dcfd3eff9c80341f69a7bc55cafd44dd357704bfc49cc7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/bundle.json","state_url":"https://pith.science/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-19T21:57:33Z","links":{"resolver":"https://pith.science/pith/NKJISCYS5Z6YDISRG4TIRSA6KM","bundle":"https://pith.science/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/bundle.json","state":"https://pith.science/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NKJISCYS5Z6YDISRG4TIRSA6KM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:NKJISCYS5Z6YDISRG4TIRSA6KM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b564dfa8abc8efcf7fe03c96f2e90dacbbcffc7f827ec8270f3772ea8a3e2f13","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-12-29T13:04:05Z","title_canon_sha256":"18578addacfd57afcbf2cdf82fd9c8aa8666a3332f5c65859da597d991ddb433"},"schema_version":"1.0","source":{"id":"1312.7532","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1312.7532","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"arxiv_version","alias_value":"1312.7532v1","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1312.7532","created_at":"2026-05-18T03:03:43Z"},{"alias_kind":"pith_short_12","alias_value":"NKJISCYS5Z6Y","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_16","alias_value":"NKJISCYS5Z6YDISR","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_8","alias_value":"NKJISCYS","created_at":"2026-05-18T12:27:52Z"}],"graph_snapshots":[{"event_id":"sha256:610eac7f30e0817cc8dcfd3eff9c80341f69a7bc55cafd44dd357704bfc49cc7","target":"graph","created_at":"2026-05-18T03:03:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Antibody-functionalized silicon nanowire field-effect transistors have been shown to exhibit excellent analyte detection sensitivity enabling sensing of analyte concentrations at levels not readily accessible by other methods. One example where accurate measurement of small concentrations is necessary is detection of serum biomarkers, such as the recently discovered tumor necrosis factor receptor superfamily member TROY (TNFRSF19), which may serve as a biomarker for melanoma. TROY is normally only present in brain but it is aberrantly expressed in primary and metastatic melanoma cells and shed","authors_text":"Carsten Maedler, Daniel Kim, Mi Hong, Pritiraj Mohanty, Remco A. Spanjaard, Shyamsunder Erramilli","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-12-29T13:04:05Z","title":"Detection of the melanoma biomarker TROY using silicon nanowire field-effect transistors"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1312.7532","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f05c0c1cdbbfac52a18fc5dbd6d09b769850957ae99536e8055e1d52f95acadb","target":"record","created_at":"2026-05-18T03:03:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b564dfa8abc8efcf7fe03c96f2e90dacbbcffc7f827ec8270f3772ea8a3e2f13","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-12-29T13:04:05Z","title_canon_sha256":"18578addacfd57afcbf2cdf82fd9c8aa8666a3332f5c65859da597d991ddb433"},"schema_version":"1.0","source":{"id":"1312.7532","kind":"arxiv","version":1}},"canonical_sha256":"6a92890b12ee7d81a251372688c81e533873758d89ce44230474d574a0170abc","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6a92890b12ee7d81a251372688c81e533873758d89ce44230474d574a0170abc","first_computed_at":"2026-05-18T03:03:43.140628Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:03:43.140628Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bKlGIg/JJV1QA3DdBMWZ/iUZZRy4OA2Z+Vi6OT3/mrGKAFVmFo2nbtu8Rx3cqn/yA7tPT/kSxzfPj2q/kAzhBw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:03:43.141438Z","signed_message":"canonical_sha256_bytes"},"source_id":"1312.7532","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f05c0c1cdbbfac52a18fc5dbd6d09b769850957ae99536e8055e1d52f95acadb","sha256:610eac7f30e0817cc8dcfd3eff9c80341f69a7bc55cafd44dd357704bfc49cc7"],"state_sha256":"19ccac7101e2f546157db862236423ae8bf2aa869dbcf0790f348dab2ca2625b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cbSG9fndYCEzXmnsWto0vWLh0k2SrtnWMqPdQm8WCgXFiAZZ5+xn918Ly4ncxMGq8vXfQMtZuIUgrzWszgFGBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-19T21:57:33.287303Z","bundle_sha256":"78671644f33c1fee0fdfdfc467ab0caef8ea8d955a89484fa2f356675fb3ced1"}}