{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:NMJLJQFIR3MCXNTTWGZYFXDENA","short_pith_number":"pith:NMJLJQFI","canonical_record":{"source":{"id":"1802.09741","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-27T06:32:05Z","cross_cats_sorted":[],"title_canon_sha256":"7faa7c46f3e0325963cd6c8f0b9312d4d50adc8f29b11f22e443d176a1ec9a4a","abstract_canon_sha256":"cc2d7a91b72ff9e5ccd64463136fb3a2504623346286098757a2711316c00c23"},"schema_version":"1.0"},"canonical_sha256":"6b12b4c0a88ed82bb673b1b382dc64681b1de466d1527ecee55049fa37fe6ccd","source":{"kind":"arxiv","id":"1802.09741","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.09741","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"arxiv_version","alias_value":"1802.09741v2","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.09741","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"pith_short_12","alias_value":"NMJLJQFIR3MC","created_at":"2026-05-18T12:32:40Z"},{"alias_kind":"pith_short_16","alias_value":"NMJLJQFIR3MCXNTT","created_at":"2026-05-18T12:32:40Z"},{"alias_kind":"pith_short_8","alias_value":"NMJLJQFI","created_at":"2026-05-18T12:32:40Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:NMJLJQFIR3MCXNTTWGZYFXDENA","target":"record","payload":{"canonical_record":{"source":{"id":"1802.09741","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-27T06:32:05Z","cross_cats_sorted":[],"title_canon_sha256":"7faa7c46f3e0325963cd6c8f0b9312d4d50adc8f29b11f22e443d176a1ec9a4a","abstract_canon_sha256":"cc2d7a91b72ff9e5ccd64463136fb3a2504623346286098757a2711316c00c23"},"schema_version":"1.0"},"canonical_sha256":"6b12b4c0a88ed82bb673b1b382dc64681b1de466d1527ecee55049fa37fe6ccd","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:22:18.166593Z","signature_b64":"cN6Y37KYirrr113v82Tqt0/cSAP0YPoQC+VOg51CG28w/iJbI8c46ie547U0Fysf5w3ctb3mZ9khtvCUTVmnAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6b12b4c0a88ed82bb673b1b382dc64681b1de466d1527ecee55049fa37fe6ccd","last_reissued_at":"2026-05-18T00:22:18.165909Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:22:18.165909Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1802.09741","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:22:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"tbB9rq4FO3/BokAVr37V67xaTncin+c6mrYIamfuyxKAcIrTvEeZM1p46dWUD85Xoc6JLU8l/XpSO3jKejHxCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T11:16:45.930639Z"},"content_sha256":"62d91680b0322320c51b385a85ace06c15e117eccb968815d72dcc4803bf14a6","schema_version":"1.0","event_id":"sha256:62d91680b0322320c51b385a85ace06c15e117eccb968815d72dcc4803bf14a6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:NMJLJQFIR3MCXNTTWGZYFXDENA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Kumiko Hayashi, Shin Hasegawa, Shinsuke Niwa, Sohei Tasaki, Takashi Sagawa","submitted_at":"2018-02-27T06:32:05Z","abstract_excerpt":"Kinesin superfamily protein UNC-104, a member of the kinesin-3 family, transports synaptic vesicle precursors (SVPs). In this study, the number of active UNC-104 molecules hauling a single SVP in axons in the worm Caenorhabditis elegans was counted by applying a newly developed non-invasive force measurement technique. The distribution of the force acting on a SVP transported by UNC-104 was spread out over several clusters, implying the presence of several force-producing units (FPUs). We then compared the number of FPUs in the wild-type worms with that in arl-8 gene-deletion mutant worms. ARL"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.09741","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:22:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0Bnjzs8Tqk6QVjL/gbG102PP9nhpPJwN1TtJTY8Gz2Wpu0DkWxooD9Z/uPOKjhmzkKp2C+JgnWGWVPMBAPZWDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T11:16:45.931201Z"},"content_sha256":"c67f11c3eb6665741bb3e4c6d219befa67a90cc8585426bd665335b9bae4d2e2","schema_version":"1.0","event_id":"sha256:c67f11c3eb6665741bb3e4c6d219befa67a90cc8585426bd665335b9bae4d2e2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/bundle.json","state_url":"https://pith.science/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T11:16:45Z","links":{"resolver":"https://pith.science/pith/NMJLJQFIR3MCXNTTWGZYFXDENA","bundle":"https://pith.science/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/bundle.json","state":"https://pith.science/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NMJLJQFIR3MCXNTTWGZYFXDENA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:NMJLJQFIR3MCXNTTWGZYFXDENA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cc2d7a91b72ff9e5ccd64463136fb3a2504623346286098757a2711316c00c23","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-27T06:32:05Z","title_canon_sha256":"7faa7c46f3e0325963cd6c8f0b9312d4d50adc8f29b11f22e443d176a1ec9a4a"},"schema_version":"1.0","source":{"id":"1802.09741","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.09741","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"arxiv_version","alias_value":"1802.09741v2","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.09741","created_at":"2026-05-18T00:22:18Z"},{"alias_kind":"pith_short_12","alias_value":"NMJLJQFIR3MC","created_at":"2026-05-18T12:32:40Z"},{"alias_kind":"pith_short_16","alias_value":"NMJLJQFIR3MCXNTT","created_at":"2026-05-18T12:32:40Z"},{"alias_kind":"pith_short_8","alias_value":"NMJLJQFI","created_at":"2026-05-18T12:32:40Z"}],"graph_snapshots":[{"event_id":"sha256:c67f11c3eb6665741bb3e4c6d219befa67a90cc8585426bd665335b9bae4d2e2","target":"graph","created_at":"2026-05-18T00:22:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Kinesin superfamily protein UNC-104, a member of the kinesin-3 family, transports synaptic vesicle precursors (SVPs). In this study, the number of active UNC-104 molecules hauling a single SVP in axons in the worm Caenorhabditis elegans was counted by applying a newly developed non-invasive force measurement technique. The distribution of the force acting on a SVP transported by UNC-104 was spread out over several clusters, implying the presence of several force-producing units (FPUs). We then compared the number of FPUs in the wild-type worms with that in arl-8 gene-deletion mutant worms. ARL","authors_text":"Kumiko Hayashi, Shin Hasegawa, Shinsuke Niwa, Sohei Tasaki, Takashi Sagawa","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-27T06:32:05Z","title":"Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.09741","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:62d91680b0322320c51b385a85ace06c15e117eccb968815d72dcc4803bf14a6","target":"record","created_at":"2026-05-18T00:22:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cc2d7a91b72ff9e5ccd64463136fb3a2504623346286098757a2711316c00c23","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-27T06:32:05Z","title_canon_sha256":"7faa7c46f3e0325963cd6c8f0b9312d4d50adc8f29b11f22e443d176a1ec9a4a"},"schema_version":"1.0","source":{"id":"1802.09741","kind":"arxiv","version":2}},"canonical_sha256":"6b12b4c0a88ed82bb673b1b382dc64681b1de466d1527ecee55049fa37fe6ccd","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6b12b4c0a88ed82bb673b1b382dc64681b1de466d1527ecee55049fa37fe6ccd","first_computed_at":"2026-05-18T00:22:18.165909Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:22:18.165909Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"cN6Y37KYirrr113v82Tqt0/cSAP0YPoQC+VOg51CG28w/iJbI8c46ie547U0Fysf5w3ctb3mZ9khtvCUTVmnAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:22:18.166593Z","signed_message":"canonical_sha256_bytes"},"source_id":"1802.09741","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:62d91680b0322320c51b385a85ace06c15e117eccb968815d72dcc4803bf14a6","sha256:c67f11c3eb6665741bb3e4c6d219befa67a90cc8585426bd665335b9bae4d2e2"],"state_sha256":"16bf50f5fc2879d6c18f0e6e6cee0335a4b12e60f24d6f95053e3b134025efc1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oeebY3OW+PYzybBUpowWSzeAMbz3w6t3rctlSwJnBK+7Yu8LeIjDbbqOUWLdFsFg04d/a41Nlcbdhrcsnz+5Bw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T11:16:45.933955Z","bundle_sha256":"8cbc14639c191cd08897108d4f1a6f8631950f14fd87eab83a794e2de7197bb0"}}