{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:NMZCBPD37BLOJJVPBM76LPDEE5","short_pith_number":"pith:NMZCBPD3","schema_version":"1.0","canonical_sha256":"6b3220bc7bf856e4a6af0b3fe5bc6427728dcf6b11d4b8c630f9fc48d88bf6bc","source":{"kind":"arxiv","id":"1410.6993","version":1},"attestation_state":"computed","paper":{"title":"Gene switching rate determines response to extrinsic perturbations in a transcriptional network motif","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Alberto d'Onofrio, Giulio Caravagna, Sebastiano de Franciscis","submitted_at":"2014-10-26T06:43:25Z","abstract_excerpt":"It is well-known that gene activation/deactivation dynamics may be a major source of randomness in genetic networks, also in the case of large concentrations of the transcription factors. In this work, we investigate the effect of realistic extrinsic noises acting on gene deactivation in a common network motif - the positive feedback of a transcription factor on its own synthesis - under a variety of settings, i.e., distinct cellular types, distribution of proteins and properties of the external perturbations. At variance with standard models where the perturbations are Gaussian unbounded, we "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1410.6993","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-10-26T06:43:25Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.QM"],"title_canon_sha256":"882a5a518f138efdb11febb0953fba7188b30b037036ecb5b4a616a15add02dd","abstract_canon_sha256":"bec0de50af7ffc2c3639c57c5783adabe5a43c81e6ec17aa967dd728a7805eb2"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:39:18.208813Z","signature_b64":"2cgyNrKNunjI/Ej80l2bzNsfKAMHwER1hoohXfPQDzRHYhiwzl3i0Deb2Sct+mzGjXGCtJ4UmH03szzOeVbBBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6b3220bc7bf856e4a6af0b3fe5bc6427728dcf6b11d4b8c630f9fc48d88bf6bc","last_reissued_at":"2026-05-18T02:39:18.208434Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:39:18.208434Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Gene switching rate determines response to extrinsic perturbations in a transcriptional network motif","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.QM"],"primary_cat":"q-bio.MN","authors_text":"Alberto d'Onofrio, Giulio Caravagna, Sebastiano de Franciscis","submitted_at":"2014-10-26T06:43:25Z","abstract_excerpt":"It is well-known that gene activation/deactivation dynamics may be a major source of randomness in genetic networks, also in the case of large concentrations of the transcription factors. In this work, we investigate the effect of realistic extrinsic noises acting on gene deactivation in a common network motif - the positive feedback of a transcription factor on its own synthesis - under a variety of settings, i.e., distinct cellular types, distribution of proteins and properties of the external perturbations. At variance with standard models where the perturbations are Gaussian unbounded, we "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1410.6993","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1410.6993","created_at":"2026-05-18T02:39:18.208492+00:00"},{"alias_kind":"arxiv_version","alias_value":"1410.6993v1","created_at":"2026-05-18T02:39:18.208492+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1410.6993","created_at":"2026-05-18T02:39:18.208492+00:00"},{"alias_kind":"pith_short_12","alias_value":"NMZCBPD37BLO","created_at":"2026-05-18T12:28:41.024544+00:00"},{"alias_kind":"pith_short_16","alias_value":"NMZCBPD37BLOJJVP","created_at":"2026-05-18T12:28:41.024544+00:00"},{"alias_kind":"pith_short_8","alias_value":"NMZCBPD3","created_at":"2026-05-18T12:28:41.024544+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5","json":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5.json","graph_json":"https://pith.science/api/pith-number/NMZCBPD37BLOJJVPBM76LPDEE5/graph.json","events_json":"https://pith.science/api/pith-number/NMZCBPD37BLOJJVPBM76LPDEE5/events.json","paper":"https://pith.science/paper/NMZCBPD3"},"agent_actions":{"view_html":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5","download_json":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5.json","view_paper":"https://pith.science/paper/NMZCBPD3","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1410.6993&json=true","fetch_graph":"https://pith.science/api/pith-number/NMZCBPD37BLOJJVPBM76LPDEE5/graph.json","fetch_events":"https://pith.science/api/pith-number/NMZCBPD37BLOJJVPBM76LPDEE5/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5/action/timestamp_anchor","attest_storage":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5/action/storage_attestation","attest_author":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5/action/author_attestation","sign_citation":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5/action/citation_signature","submit_replication":"https://pith.science/pith/NMZCBPD37BLOJJVPBM76LPDEE5/action/replication_record"}},"created_at":"2026-05-18T02:39:18.208492+00:00","updated_at":"2026-05-18T02:39:18.208492+00:00"}