{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:NOFLFDVORZQBKOV4KNZMQQMMWA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"eeef3716d6263a1d0aff237fb42de9927520b31a885bde55cf3631f34dbf2fbd","cross_cats_sorted":["physics.chem-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2024-04-22T11:40:08Z","title_canon_sha256":"eefd38e62a6afe0d7c96afe7cbe0cfe251cd6b35af178a0ef538fff6b67a8aa1"},"schema_version":"1.0","source":{"id":"2404.14101","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2404.14101","created_at":"2026-07-05T08:10:41Z"},{"alias_kind":"arxiv_version","alias_value":"2404.14101v1","created_at":"2026-07-05T08:10:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2404.14101","created_at":"2026-07-05T08:10:41Z"},{"alias_kind":"pith_short_12","alias_value":"NOFLFDVORZQB","created_at":"2026-07-05T08:10:41Z"},{"alias_kind":"pith_short_16","alias_value":"NOFLFDVORZQBKOV4","created_at":"2026-07-05T08:10:41Z"},{"alias_kind":"pith_short_8","alias_value":"NOFLFDVO","created_at":"2026-07-05T08:10:41Z"}],"graph_snapshots":[{"event_id":"sha256:ecf72754e7d963346345a8821b232110cc35e4513bbfd5fd48e1c948684a28d5","target":"graph","created_at":"2026-07-05T08:10:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2404.14101/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving certain combinatorial optimization problems over traditional classical methods such as simulated annealing (SA). However, a recent study showed that a 2000-qubit QA hardware was still unable to outperform SA for the MU problem. Here, we propose the use of quantum-inspired algorithm to solve the MU problem, in order to go beyond traditional SA. We introduce a hig","authors_text":"Bi-Ying Wang, Bowen Liu, Huangjun Zhu, Man-Hong Yung, Nan Qiao, Runqiu Shu, Xiaopeng Cui, Yunting Li, Zhaoping Xiong, Zuoheng Zou","cross_cats":["physics.chem-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2024-04-22T11:40:08Z","title":"Efficient molecular conformation generation with quantum-inspired algorithm"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2404.14101","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:55f3c92756ea576bc5a53b521942182d67d9a7799ee73bc3b6452d493382e4c4","target":"record","created_at":"2026-07-05T08:10:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"eeef3716d6263a1d0aff237fb42de9927520b31a885bde55cf3631f34dbf2fbd","cross_cats_sorted":["physics.chem-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2024-04-22T11:40:08Z","title_canon_sha256":"eefd38e62a6afe0d7c96afe7cbe0cfe251cd6b35af178a0ef538fff6b67a8aa1"},"schema_version":"1.0","source":{"id":"2404.14101","kind":"arxiv","version":1}},"canonical_sha256":"6b8ab28eae8e60153abc5372c8418cb02115eabb6d13b3e34fe70f21f58cb4df","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6b8ab28eae8e60153abc5372c8418cb02115eabb6d13b3e34fe70f21f58cb4df","first_computed_at":"2026-07-05T08:10:41.816894Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:10:41.816894Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"n7r4exMlVUiW2KviKPqkMAjeouTaw63I9PBbB4s1fs2Q4mUa+3BqVwEZA1rrdr3PRZ7A6Ol+PebiXOFRe6RDDA==","signature_status":"signed_v1","signed_at":"2026-07-05T08:10:41.817450Z","signed_message":"canonical_sha256_bytes"},"source_id":"2404.14101","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:55f3c92756ea576bc5a53b521942182d67d9a7799ee73bc3b6452d493382e4c4","sha256:ecf72754e7d963346345a8821b232110cc35e4513bbfd5fd48e1c948684a28d5"],"state_sha256":"a95f452e622d99c64385ec491d36c87c85c7356019d01ceaecb4e01ea844163c"}