{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:NQVMOK5TG4TJUXGSCG2CNOF24Z","short_pith_number":"pith:NQVMOK5T","schema_version":"1.0","canonical_sha256":"6c2ac72bb337269a5cd211b426b8bae672dbe42ec598ab1576bea0c5d66d8938","source":{"kind":"arxiv","id":"1605.06737","version":1},"attestation_state":"computed","paper":{"title":"An unbiased metric of antiproliferative drug effect in vitro","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"q-bio.QM","authors_text":"B. Bishal Paudel, Carlos F. Lopez, Darren R. Tyson, Keisha N. Hardeman, Leonard A. Harris, Peter L. Frick, Shawn P. Garbett, Vito Quaranta","submitted_at":"2016-05-22T05:28:19Z","abstract_excerpt":"In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current antiproliferative drug effect metrics suffer from time-dependent bias, leading to inaccurate assessments of parameters such as drug potency and efficacy. We propose the drug-induced proliferation (DIP) rate, the slope of the line on a plot of cell population doublings versus time, as an alternative, time-independent metric."},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1605.06737","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-05-22T05:28:19Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"dac458f6efece9593b82b61a97df2077aa0660eff696244ed1d4ecbab9bb3d1c","abstract_canon_sha256":"0f9e5d074f19aba0fe2ea0f0ca78f761c5fc1b362df8609027ae9fc34691a452"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:57:43.977748Z","signature_b64":"CtSEtTP4bomGs9CdxnGCpJhmXd4AG5Sjccm9bLaHbCVM6oBUSxmi2MAdOx4d0sD0Hj/dOCtkXfW0RG9l5BILBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6c2ac72bb337269a5cd211b426b8bae672dbe42ec598ab1576bea0c5d66d8938","last_reissued_at":"2026-05-18T00:57:43.977389Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:57:43.977389Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"An unbiased metric of antiproliferative drug effect in vitro","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"q-bio.QM","authors_text":"B. Bishal Paudel, Carlos F. Lopez, Darren R. Tyson, Keisha N. Hardeman, Leonard A. Harris, Peter L. Frick, Shawn P. Garbett, Vito Quaranta","submitted_at":"2016-05-22T05:28:19Z","abstract_excerpt":"In vitro cell proliferation assays are widely used in pharmacology, molecular biology, and drug discovery. Using theoretical modeling and experimentation, we show that current antiproliferative drug effect metrics suffer from time-dependent bias, leading to inaccurate assessments of parameters such as drug potency and efficacy. We propose the drug-induced proliferation (DIP) rate, the slope of the line on a plot of cell population doublings versus time, as an alternative, time-independent metric."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1605.06737","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1605.06737","created_at":"2026-05-18T00:57:43.977451+00:00"},{"alias_kind":"arxiv_version","alias_value":"1605.06737v1","created_at":"2026-05-18T00:57:43.977451+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1605.06737","created_at":"2026-05-18T00:57:43.977451+00:00"},{"alias_kind":"pith_short_12","alias_value":"NQVMOK5TG4TJ","created_at":"2026-05-18T12:30:36.002864+00:00"},{"alias_kind":"pith_short_16","alias_value":"NQVMOK5TG4TJUXGS","created_at":"2026-05-18T12:30:36.002864+00:00"},{"alias_kind":"pith_short_8","alias_value":"NQVMOK5T","created_at":"2026-05-18T12:30:36.002864+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z","json":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z.json","graph_json":"https://pith.science/api/pith-number/NQVMOK5TG4TJUXGSCG2CNOF24Z/graph.json","events_json":"https://pith.science/api/pith-number/NQVMOK5TG4TJUXGSCG2CNOF24Z/events.json","paper":"https://pith.science/paper/NQVMOK5T"},"agent_actions":{"view_html":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z","download_json":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z.json","view_paper":"https://pith.science/paper/NQVMOK5T","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1605.06737&json=true","fetch_graph":"https://pith.science/api/pith-number/NQVMOK5TG4TJUXGSCG2CNOF24Z/graph.json","fetch_events":"https://pith.science/api/pith-number/NQVMOK5TG4TJUXGSCG2CNOF24Z/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z/action/timestamp_anchor","attest_storage":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z/action/storage_attestation","attest_author":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z/action/author_attestation","sign_citation":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z/action/citation_signature","submit_replication":"https://pith.science/pith/NQVMOK5TG4TJUXGSCG2CNOF24Z/action/replication_record"}},"created_at":"2026-05-18T00:57:43.977451+00:00","updated_at":"2026-05-18T00:57:43.977451+00:00"}