{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:NSXA6T76PSYKGAOHRWQGU2QDBR","short_pith_number":"pith:NSXA6T76","canonical_record":{"source":{"id":"1608.07616","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2016-08-26T21:53:30Z","cross_cats_sorted":[],"title_canon_sha256":"b606c4fe1958e0e0abbc6422c3f25b60740bdb8ac9961cc1b4b264c4de6bff7f","abstract_canon_sha256":"e519882dc0170799d5ee064b1c6244c439502834ca09eb1e871f22e80370ac78"},"schema_version":"1.0"},"canonical_sha256":"6cae0f4ffe7cb0a301c78da06a6a030c771f88c86168bc1d4590ff8afaed82f4","source":{"kind":"arxiv","id":"1608.07616","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1608.07616","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"arxiv_version","alias_value":"1608.07616v1","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1608.07616","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"pith_short_12","alias_value":"NSXA6T76PSYK","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_16","alias_value":"NSXA6T76PSYKGAOH","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_8","alias_value":"NSXA6T76","created_at":"2026-05-18T12:30:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:NSXA6T76PSYKGAOHRWQGU2QDBR","target":"record","payload":{"canonical_record":{"source":{"id":"1608.07616","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2016-08-26T21:53:30Z","cross_cats_sorted":[],"title_canon_sha256":"b606c4fe1958e0e0abbc6422c3f25b60740bdb8ac9961cc1b4b264c4de6bff7f","abstract_canon_sha256":"e519882dc0170799d5ee064b1c6244c439502834ca09eb1e871f22e80370ac78"},"schema_version":"1.0"},"canonical_sha256":"6cae0f4ffe7cb0a301c78da06a6a030c771f88c86168bc1d4590ff8afaed82f4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:07:50.275798Z","signature_b64":"oX0GQF/OzNvfLXwBW4uCqjJ5y+0vn84dorY0blCL/XDFI8yiKzo9pOPV1+KZ+kDmeiSi6gJHtoStUt/Jo7nfCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6cae0f4ffe7cb0a301c78da06a6a030c771f88c86168bc1d4590ff8afaed82f4","last_reissued_at":"2026-05-18T01:07:50.275153Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:07:50.275153Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1608.07616","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:07:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"7d9rR5Dx5vxAtuoHOEYCtdrZx+t2FIjTYarFB4KhKkwJZtSy2npBvZBHySgIv8b9XlwYIogFOJhSBduEqdRMDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T05:10:47.102014Z"},"content_sha256":"4102300bcb36da4eb02728abd8cfe53308d4d6bd6c69f88f917053dfc3a10414","schema_version":"1.0","event_id":"sha256:4102300bcb36da4eb02728abd8cfe53308d4d6bd6c69f88f917053dfc3a10414"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:NSXA6T76PSYKGAOHRWQGU2QDBR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Mitosis Detection in Intestinal Crypt Images with Hough Forest and Conditional Random Fields","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cs.CV","authors_text":"Anika B\\\"ottcher, Fabian Theis, Fausto Milletari, Gerda Bortsova, Heiko Lickert, Lichao Wang, Michael Sterr, Nassir Navab, Tingying Peng","submitted_at":"2016-08-26T21:53:30Z","abstract_excerpt":"Intestinal enteroendocrine cells secrete hormones that are vital for the regulation of glucose metabolism but their differentiation from intestinal stem cells is not fully understood. Asymmetric stem cell divisions have been linked to intestinal stem cell homeostasis and secretory fate commitment. We monitored cell divisions using 4D live cell imaging of cultured intestinal crypts to characterize division modes by means of measurable features such as orientation or shape. A statistical analysis of these measurements requires annotation of mitosis events, which is currently a tedious and time-c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1608.07616","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:07:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WZh2uUc24g5pBpHfocgrmsWG5Jrepx1dndsfeMHcSO8s/rAlHzsGt7p6mUdCidXz7mVVW1AguedTirQ4IzlOCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T05:10:47.102721Z"},"content_sha256":"be9a6b2b62e5db49ff0c37c232a3173f4bc2d23ca622232c13404d042b4b6e11","schema_version":"1.0","event_id":"sha256:be9a6b2b62e5db49ff0c37c232a3173f4bc2d23ca622232c13404d042b4b6e11"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/bundle.json","state_url":"https://pith.science/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T05:10:47Z","links":{"resolver":"https://pith.science/pith/NSXA6T76PSYKGAOHRWQGU2QDBR","bundle":"https://pith.science/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/bundle.json","state":"https://pith.science/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NSXA6T76PSYKGAOHRWQGU2QDBR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:NSXA6T76PSYKGAOHRWQGU2QDBR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e519882dc0170799d5ee064b1c6244c439502834ca09eb1e871f22e80370ac78","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2016-08-26T21:53:30Z","title_canon_sha256":"b606c4fe1958e0e0abbc6422c3f25b60740bdb8ac9961cc1b4b264c4de6bff7f"},"schema_version":"1.0","source":{"id":"1608.07616","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1608.07616","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"arxiv_version","alias_value":"1608.07616v1","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1608.07616","created_at":"2026-05-18T01:07:50Z"},{"alias_kind":"pith_short_12","alias_value":"NSXA6T76PSYK","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_16","alias_value":"NSXA6T76PSYKGAOH","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_8","alias_value":"NSXA6T76","created_at":"2026-05-18T12:30:36Z"}],"graph_snapshots":[{"event_id":"sha256:be9a6b2b62e5db49ff0c37c232a3173f4bc2d23ca622232c13404d042b4b6e11","target":"graph","created_at":"2026-05-18T01:07:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Intestinal enteroendocrine cells secrete hormones that are vital for the regulation of glucose metabolism but their differentiation from intestinal stem cells is not fully understood. Asymmetric stem cell divisions have been linked to intestinal stem cell homeostasis and secretory fate commitment. We monitored cell divisions using 4D live cell imaging of cultured intestinal crypts to characterize division modes by means of measurable features such as orientation or shape. A statistical analysis of these measurements requires annotation of mitosis events, which is currently a tedious and time-c","authors_text":"Anika B\\\"ottcher, Fabian Theis, Fausto Milletari, Gerda Bortsova, Heiko Lickert, Lichao Wang, Michael Sterr, Nassir Navab, Tingying Peng","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2016-08-26T21:53:30Z","title":"Mitosis Detection in Intestinal Crypt Images with Hough Forest and Conditional Random Fields"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1608.07616","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4102300bcb36da4eb02728abd8cfe53308d4d6bd6c69f88f917053dfc3a10414","target":"record","created_at":"2026-05-18T01:07:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e519882dc0170799d5ee064b1c6244c439502834ca09eb1e871f22e80370ac78","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.CV","submitted_at":"2016-08-26T21:53:30Z","title_canon_sha256":"b606c4fe1958e0e0abbc6422c3f25b60740bdb8ac9961cc1b4b264c4de6bff7f"},"schema_version":"1.0","source":{"id":"1608.07616","kind":"arxiv","version":1}},"canonical_sha256":"6cae0f4ffe7cb0a301c78da06a6a030c771f88c86168bc1d4590ff8afaed82f4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6cae0f4ffe7cb0a301c78da06a6a030c771f88c86168bc1d4590ff8afaed82f4","first_computed_at":"2026-05-18T01:07:50.275153Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:07:50.275153Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oX0GQF/OzNvfLXwBW4uCqjJ5y+0vn84dorY0blCL/XDFI8yiKzo9pOPV1+KZ+kDmeiSi6gJHtoStUt/Jo7nfCA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:07:50.275798Z","signed_message":"canonical_sha256_bytes"},"source_id":"1608.07616","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4102300bcb36da4eb02728abd8cfe53308d4d6bd6c69f88f917053dfc3a10414","sha256:be9a6b2b62e5db49ff0c37c232a3173f4bc2d23ca622232c13404d042b4b6e11"],"state_sha256":"ca09428a0cb6f9f14f4513f4f8d665ca29945284a8ef80c8dc8daae5b6e9aa64"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kJgiwX8J4itPSq5eFikueIN3Y/mgfVq0iXHgOoYCA5RMCAXYrgGARmXyuh5gYDavyVYcE4okS7H5Ny5hy9i2CQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T05:10:47.106290Z","bundle_sha256":"4013923269647d97d1cc32328bb8c0d3eb9b0a242d495ff5172dddf8e94d7b07"}}