{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:NWSVETSSM2RVTSK5UGSGQ32RJ7","short_pith_number":"pith:NWSVETSS","canonical_record":{"source":{"id":"1310.0889","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-10-03T03:45:18Z","cross_cats_sorted":[],"title_canon_sha256":"e1eaca688fa764305149de35b433534a1d9e1b65387ecbd96f58fa70df821658","abstract_canon_sha256":"ff8939fba5474262517531b8b2dae23bdff89ba3619756bb90c9d896b100a979"},"schema_version":"1.0"},"canonical_sha256":"6da5524e5266a359c95da1a4686f514fc5457787775d6b163e7705ac936b1fc2","source":{"kind":"arxiv","id":"1310.0889","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1310.0889","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"arxiv_version","alias_value":"1310.0889v2","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1310.0889","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"pith_short_12","alias_value":"NWSVETSSM2RV","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_16","alias_value":"NWSVETSSM2RVTSK5","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_8","alias_value":"NWSVETSS","created_at":"2026-05-18T12:27:52Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:NWSVETSSM2RVTSK5UGSGQ32RJ7","target":"record","payload":{"canonical_record":{"source":{"id":"1310.0889","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-10-03T03:45:18Z","cross_cats_sorted":[],"title_canon_sha256":"e1eaca688fa764305149de35b433534a1d9e1b65387ecbd96f58fa70df821658","abstract_canon_sha256":"ff8939fba5474262517531b8b2dae23bdff89ba3619756bb90c9d896b100a979"},"schema_version":"1.0"},"canonical_sha256":"6da5524e5266a359c95da1a4686f514fc5457787775d6b163e7705ac936b1fc2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:05:01.150420Z","signature_b64":"uqi+pND62cyAMIspLYYPY5GvTI5UqnX4Kpf1stoi2KOWe5TnlwfvevW1Jf0z+KBucJZtqZgVM/PEiPJNvqkODA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"6da5524e5266a359c95da1a4686f514fc5457787775d6b163e7705ac936b1fc2","last_reissued_at":"2026-05-18T03:05:01.149889Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:05:01.149889Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1310.0889","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:05:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"P5QCsWPuiQK1IC/Bo5wOjl2v8ChLGw+AO3V7vqLfhbX1fsbcWm6wtoVv5tKWFPTNEd5K9fg5yvbijVC2WnvjAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T15:53:53.900732Z"},"content_sha256":"db3e9a8b997bbc9b920bb37e1afba0323611fcbf171d11f8b8cdb14fe09e8e56","schema_version":"1.0","event_id":"sha256:db3e9a8b997bbc9b920bb37e1afba0323611fcbf171d11f8b8cdb14fe09e8e56"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:NWSVETSSM2RVTSK5UGSGQ32RJ7","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Structural flexibility of intrinsically disordered proteins induces stepwise target recognition","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Macoto Kikuchi, Nobu C. Shirai","submitted_at":"2013-10-03T03:45:18Z","abstract_excerpt":"An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes. We consider that stepwise target recognition via intermediate states is a characteristic of IDP binding to targets with \"hidden\" binding sites. To investigate IDP binding to hidden target binding sites, we constructed an IDP lattice model based on the HP model. In our model, the ID"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1310.0889","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:05:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XzP/z3mH05cN8Z2fAjjF0QQp0EhF82TvKH+8XcHVhbuYB2qXea+kh8Rupgo78eNiMMLFhc4252GGbeNsrpZ9CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T15:53:53.901095Z"},"content_sha256":"dc61b0a895b27b9b78daf021a1b7006b28330f5b2cb678465e3e8aa881fc1959","schema_version":"1.0","event_id":"sha256:dc61b0a895b27b9b78daf021a1b7006b28330f5b2cb678465e3e8aa881fc1959"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/bundle.json","state_url":"https://pith.science/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T15:53:53Z","links":{"resolver":"https://pith.science/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7","bundle":"https://pith.science/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/bundle.json","state":"https://pith.science/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/state.json","well_known_bundle":"https://pith.science/.well-known/pith/NWSVETSSM2RVTSK5UGSGQ32RJ7/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:NWSVETSSM2RVTSK5UGSGQ32RJ7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ff8939fba5474262517531b8b2dae23bdff89ba3619756bb90c9d896b100a979","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-10-03T03:45:18Z","title_canon_sha256":"e1eaca688fa764305149de35b433534a1d9e1b65387ecbd96f58fa70df821658"},"schema_version":"1.0","source":{"id":"1310.0889","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1310.0889","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"arxiv_version","alias_value":"1310.0889v2","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1310.0889","created_at":"2026-05-18T03:05:01Z"},{"alias_kind":"pith_short_12","alias_value":"NWSVETSSM2RV","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_16","alias_value":"NWSVETSSM2RVTSK5","created_at":"2026-05-18T12:27:52Z"},{"alias_kind":"pith_short_8","alias_value":"NWSVETSS","created_at":"2026-05-18T12:27:52Z"}],"graph_snapshots":[{"event_id":"sha256:dc61b0a895b27b9b78daf021a1b7006b28330f5b2cb678465e3e8aa881fc1959","target":"graph","created_at":"2026-05-18T03:05:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"An intrinsically disordered protein (IDP) lacks a stable three-dimensional structure, while it folds into a specific structure when it binds to a target molecule. In some IDP-target complexes, not all target binding surfaces are exposed on the outside, and intermediate states are observed in their binding processes. We consider that stepwise target recognition via intermediate states is a characteristic of IDP binding to targets with \"hidden\" binding sites. To investigate IDP binding to hidden target binding sites, we constructed an IDP lattice model based on the HP model. In our model, the ID","authors_text":"Macoto Kikuchi, Nobu C. Shirai","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-10-03T03:45:18Z","title":"Structural flexibility of intrinsically disordered proteins induces stepwise target recognition"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1310.0889","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:db3e9a8b997bbc9b920bb37e1afba0323611fcbf171d11f8b8cdb14fe09e8e56","target":"record","created_at":"2026-05-18T03:05:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ff8939fba5474262517531b8b2dae23bdff89ba3619756bb90c9d896b100a979","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-10-03T03:45:18Z","title_canon_sha256":"e1eaca688fa764305149de35b433534a1d9e1b65387ecbd96f58fa70df821658"},"schema_version":"1.0","source":{"id":"1310.0889","kind":"arxiv","version":2}},"canonical_sha256":"6da5524e5266a359c95da1a4686f514fc5457787775d6b163e7705ac936b1fc2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"6da5524e5266a359c95da1a4686f514fc5457787775d6b163e7705ac936b1fc2","first_computed_at":"2026-05-18T03:05:01.149889Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:05:01.149889Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uqi+pND62cyAMIspLYYPY5GvTI5UqnX4Kpf1stoi2KOWe5TnlwfvevW1Jf0z+KBucJZtqZgVM/PEiPJNvqkODA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:05:01.150420Z","signed_message":"canonical_sha256_bytes"},"source_id":"1310.0889","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:db3e9a8b997bbc9b920bb37e1afba0323611fcbf171d11f8b8cdb14fe09e8e56","sha256:dc61b0a895b27b9b78daf021a1b7006b28330f5b2cb678465e3e8aa881fc1959"],"state_sha256":"c519b6aacb9efd74a3ae1d5875c5beead3ef1ec1d115687beb3698418b775ae9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rSkJVC/vg3sZL4qCDdlUdgsuFs6+PKJGdMfyjHcM+N+tkvDv15ZhLzDO0LwZJHoSpW/9wZiZWqnCo3Dp6hcwDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T15:53:53.903488Z","bundle_sha256":"3375527c41c5111a9f5ba0d6c968c92e8fd961e6d334ee89b0a3cdb9dbd6fea6"}}