{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:O2O3GVSCOB4IPNVCNN7HZKAW4Z","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e9f9d42e285243038c8e2c0af3b7734db3aac4345908ba149052ba7444df4850","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-29T10:22:55Z","title_canon_sha256":"b6f2c5f69f2f22157da5c37c484aae2591720287f2bff26f371b4f4504f6bffa"},"schema_version":"1.0","source":{"id":"1202.6505","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.6505","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"arxiv_version","alias_value":"1202.6505v2","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.6505","created_at":"2026-05-18T04:00:37Z"},{"alias_kind":"pith_short_12","alias_value":"O2O3GVSCOB4I","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_16","alias_value":"O2O3GVSCOB4IPNVC","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_8","alias_value":"O2O3GVSC","created_at":"2026-05-18T12:27:16Z"}],"graph_snapshots":[{"event_id":"sha256:e16c4935fb63ae293ea9d71af20899f8c20e351b8b1902ba3bdde7f51425b703","target":"graph","created_at":"2026-05-18T04:00:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Macromolecular crowding in living biological cells effects subdiffusion of larger biomolecules such as proteins and enzymes. Mimicking this subdiffusion in terms of random walks on a critical percolation cluster, we here present a case study of EcoRV restriction enzymes involved in vital cellular defence. We show that due to its so far elusive propensity to an inactive state the enzyme avoids non-specific binding and remains well-distributed in the bulk cytoplasm of the cell. Despite the reduced volume exploration capability of subdiffusion processes, this mechanism guarantees a high efficienc","authors_text":"Leila Esmaeili Sereshki, Michael A. Lomholt, Ralf Metzler","cross_cats":["cond-mat.stat-mech","physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-29T10:22:55Z","title":"A solution to the subdiffusion-efficiency paradox: Inactive states enhance reaction efficiency at subdiffusion conditions in living cells"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.6505","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:00f48db549f693407eb9c4edb9a0bb8d66b61cddd56763888a61baedd3cd3db1","target":"record","created_at":"2026-05-18T04:00:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e9f9d42e285243038c8e2c0af3b7734db3aac4345908ba149052ba7444df4850","cross_cats_sorted":["cond-mat.stat-mech","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2012-02-29T10:22:55Z","title_canon_sha256":"b6f2c5f69f2f22157da5c37c484aae2591720287f2bff26f371b4f4504f6bffa"},"schema_version":"1.0","source":{"id":"1202.6505","kind":"arxiv","version":2}},"canonical_sha256":"769db35642707887b6a26b7e7ca816e678b5b441ebaf4b64c59438c52455439b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"769db35642707887b6a26b7e7ca816e678b5b441ebaf4b64c59438c52455439b","first_computed_at":"2026-05-18T04:00:37.550254Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:00:37.550254Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"PvoLHxopxdd1qt2XypR4g+/pefOOmPpXKr7kB/oPdUyas3wQrbx8+wQPZye6asfXeEjX3thOjgvrb2rnv64eAw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:00:37.550838Z","signed_message":"canonical_sha256_bytes"},"source_id":"1202.6505","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:00f48db549f693407eb9c4edb9a0bb8d66b61cddd56763888a61baedd3cd3db1","sha256:e16c4935fb63ae293ea9d71af20899f8c20e351b8b1902ba3bdde7f51425b703"],"state_sha256":"96a28a531359d25f554fffd369469cc1584f03d69939b4d0e3017b8ef7ccd5c4"}