{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:O63SPJNJMQHQ3G24PADNLMNDW5","short_pith_number":"pith:O63SPJNJ","canonical_record":{"source":{"id":"2410.19995","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-10-25T22:38:39Z","cross_cats_sorted":[],"title_canon_sha256":"b60493540a60590d195154426d0cf58629e288fe03197cefa509283a219df9d6","abstract_canon_sha256":"7b11a5ecaa97520c070e3dcaddd94c1994c028dbb12a74bb337786dada3728dd"},"schema_version":"1.0"},"canonical_sha256":"77b727a5a9640f0d9b5c7806d5b1a3b768cb1b7b2f276924fc6af49dd677f103","source":{"kind":"arxiv","id":"2410.19995","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2410.19995","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"arxiv_version","alias_value":"2410.19995v1","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2410.19995","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_12","alias_value":"O63SPJNJMQHQ","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_16","alias_value":"O63SPJNJMQHQ3G24","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_8","alias_value":"O63SPJNJ","created_at":"2026-07-05T09:26:37Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:O63SPJNJMQHQ3G24PADNLMNDW5","target":"record","payload":{"canonical_record":{"source":{"id":"2410.19995","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-10-25T22:38:39Z","cross_cats_sorted":[],"title_canon_sha256":"b60493540a60590d195154426d0cf58629e288fe03197cefa509283a219df9d6","abstract_canon_sha256":"7b11a5ecaa97520c070e3dcaddd94c1994c028dbb12a74bb337786dada3728dd"},"schema_version":"1.0"},"canonical_sha256":"77b727a5a9640f0d9b5c7806d5b1a3b768cb1b7b2f276924fc6af49dd677f103","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:26:37.047986Z","signature_b64":"nqp4QsBrWH1ySagvMbfkTHVJH4FHCwR4js7Mg23S5kGQqOydnSG5Q65aQ7EiHvD+9373jdFJrIqVk9k4EjoxBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"77b727a5a9640f0d9b5c7806d5b1a3b768cb1b7b2f276924fc6af49dd677f103","last_reissued_at":"2026-07-05T09:26:37.047541Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:26:37.047541Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2410.19995","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:26:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gdK9p5wRH8wkVivJVE0O2u3+6188LrBGjQMxBtc05sAYOf96Zd24Yo5I2E8TubWkY6hQ4ferBm919leOjmrOBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T19:34:56.597291Z"},"content_sha256":"9435b48af5232e77cbcba96639c1813f4ce0ab340de6a7d13c51abaf36e42952","schema_version":"1.0","event_id":"sha256:9435b48af5232e77cbcba96639c1813f4ce0ab340de6a7d13c51abaf36e42952"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:O63SPJNJMQHQ3G24PADNLMNDW5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A deep-learning model for one-shot transcranial ultrasound simulation and phase aberration correction","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Gerald R. Popelka, Karanpartap Singh, Kasra Naftchi-Ardebili, Kim Butts Pauly","submitted_at":"2024-10-25T22:38:39Z","abstract_excerpt":"Transcranial ultrasound (TUS) has emerged as a promising tool in clinical and research settings due to its potential to modulate neuronal activity, open the blood-brain barrier, facilitate targeted drug delivery via nanoparticles, and perform thermal ablation, all non-invasively. By delivering focused ultrasound waves to precise regions anywhere in the brain, TUS enables targeted energy deposition and is being explored in over fifty clinical trials as a treatment for conditions such as opioid addiction, Alzheimer's disease, dementia, epilepsy, and glioblastoma. However, effective TUS treatment"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2410.19995","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2410.19995/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:26:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZqQPI3QzunwicbkIoZ5ifJamjG3mzGTfRpiX0BDtKko6172kE00VIqzbsdwRmZRSGiZ84CzOVTi5AE795ncNCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-18T19:34:56.597813Z"},"content_sha256":"02800a8fe4fa9eeb943707df4b55d6a74571a771aea8248ca170c22fada34378","schema_version":"1.0","event_id":"sha256:02800a8fe4fa9eeb943707df4b55d6a74571a771aea8248ca170c22fada34378"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/O63SPJNJMQHQ3G24PADNLMNDW5/bundle.json","state_url":"https://pith.science/pith/O63SPJNJMQHQ3G24PADNLMNDW5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/O63SPJNJMQHQ3G24PADNLMNDW5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-18T19:34:56Z","links":{"resolver":"https://pith.science/pith/O63SPJNJMQHQ3G24PADNLMNDW5","bundle":"https://pith.science/pith/O63SPJNJMQHQ3G24PADNLMNDW5/bundle.json","state":"https://pith.science/pith/O63SPJNJMQHQ3G24PADNLMNDW5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/O63SPJNJMQHQ3G24PADNLMNDW5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:O63SPJNJMQHQ3G24PADNLMNDW5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7b11a5ecaa97520c070e3dcaddd94c1994c028dbb12a74bb337786dada3728dd","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-10-25T22:38:39Z","title_canon_sha256":"b60493540a60590d195154426d0cf58629e288fe03197cefa509283a219df9d6"},"schema_version":"1.0","source":{"id":"2410.19995","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2410.19995","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"arxiv_version","alias_value":"2410.19995v1","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2410.19995","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_12","alias_value":"O63SPJNJMQHQ","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_16","alias_value":"O63SPJNJMQHQ3G24","created_at":"2026-07-05T09:26:37Z"},{"alias_kind":"pith_short_8","alias_value":"O63SPJNJ","created_at":"2026-07-05T09:26:37Z"}],"graph_snapshots":[{"event_id":"sha256:02800a8fe4fa9eeb943707df4b55d6a74571a771aea8248ca170c22fada34378","target":"graph","created_at":"2026-07-05T09:26:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2410.19995/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Transcranial ultrasound (TUS) has emerged as a promising tool in clinical and research settings due to its potential to modulate neuronal activity, open the blood-brain barrier, facilitate targeted drug delivery via nanoparticles, and perform thermal ablation, all non-invasively. By delivering focused ultrasound waves to precise regions anywhere in the brain, TUS enables targeted energy deposition and is being explored in over fifty clinical trials as a treatment for conditions such as opioid addiction, Alzheimer's disease, dementia, epilepsy, and glioblastoma. However, effective TUS treatment","authors_text":"Gerald R. Popelka, Karanpartap Singh, Kasra Naftchi-Ardebili, Kim Butts Pauly","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-10-25T22:38:39Z","title":"A deep-learning model for one-shot transcranial ultrasound simulation and phase aberration correction"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2410.19995","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9435b48af5232e77cbcba96639c1813f4ce0ab340de6a7d13c51abaf36e42952","target":"record","created_at":"2026-07-05T09:26:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7b11a5ecaa97520c070e3dcaddd94c1994c028dbb12a74bb337786dada3728dd","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-10-25T22:38:39Z","title_canon_sha256":"b60493540a60590d195154426d0cf58629e288fe03197cefa509283a219df9d6"},"schema_version":"1.0","source":{"id":"2410.19995","kind":"arxiv","version":1}},"canonical_sha256":"77b727a5a9640f0d9b5c7806d5b1a3b768cb1b7b2f276924fc6af49dd677f103","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"77b727a5a9640f0d9b5c7806d5b1a3b768cb1b7b2f276924fc6af49dd677f103","first_computed_at":"2026-07-05T09:26:37.047541Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:26:37.047541Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nqp4QsBrWH1ySagvMbfkTHVJH4FHCwR4js7Mg23S5kGQqOydnSG5Q65aQ7EiHvD+9373jdFJrIqVk9k4EjoxBA==","signature_status":"signed_v1","signed_at":"2026-07-05T09:26:37.047986Z","signed_message":"canonical_sha256_bytes"},"source_id":"2410.19995","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9435b48af5232e77cbcba96639c1813f4ce0ab340de6a7d13c51abaf36e42952","sha256:02800a8fe4fa9eeb943707df4b55d6a74571a771aea8248ca170c22fada34378"],"state_sha256":"1a6d6d062e9e2ba0bf35aa9d20b3b1cc004e5b6980a282678a1cf27f4bf53736"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"55aXXW9kZoF4RnglYRUfrL2ugQNdf6NwIcjK9v67Pz8IaycuTchvxsXNkgxGVPURc9SUcj4zUWY/yIhFz0jOBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-18T19:34:56.604611Z","bundle_sha256":"2f8bf2040d0f2c230589b691e02db010ac934b0579e5a2f19b2e65684896e902"}}