{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:O6SF7I7GR66ZCLT2APUZWN64MM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"aebad15f3613d74ec20c1c04a1d571c429091526fb5620cdae3ffad036a39ef4","cross_cats_sorted":["cond-mat.soft","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-09-10T17:44:20Z","title_canon_sha256":"05fd714c10142347c80da7fe418c234ab2712759182e95d26bd27b23d2e91105"},"schema_version":"1.0","source":{"id":"1809.03472","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1809.03472","created_at":"2026-05-18T00:06:06Z"},{"alias_kind":"arxiv_version","alias_value":"1809.03472v1","created_at":"2026-05-18T00:06:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1809.03472","created_at":"2026-05-18T00:06:06Z"},{"alias_kind":"pith_short_12","alias_value":"O6SF7I7GR66Z","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_16","alias_value":"O6SF7I7GR66ZCLT2","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_8","alias_value":"O6SF7I7G","created_at":"2026-05-18T12:32:43Z"}],"graph_snapshots":[{"event_id":"sha256:13da87cb96ec75d2df8921e98423f1ea9e5e6086cb7b488c1af6a4c6ce9241a1","target":"graph","created_at":"2026-05-18T00:06:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Liquid cellular compartments spatially segregate from the cytoplasm and can regulate aberrant protein aggregation, a process linked to several medical conditions, including Alzheimer's and Parkinson's diseases. Yet the mechanisms by which these droplet-like compartments affect protein aggregation remain unknown. Here, we combine kinetic theory of protein aggregation and liquid-liquid phase separation to study the spatial control of irreversible protein aggregation in the presence of liquid compartments. We find that, even for weak interactions between the compartment constituents and the aggre","authors_text":"Christoph A. Weber, L. Mahadevan, Thomas C. T. Michaels","cross_cats":["cond-mat.soft","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-09-10T17:44:20Z","title":"Spatial control of irreversible protein aggregation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1809.03472","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:640836732afb6e215d043529ee937209a35e952a0d8502942df582e1ec200bf7","target":"record","created_at":"2026-05-18T00:06:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"aebad15f3613d74ec20c1c04a1d571c429091526fb5620cdae3ffad036a39ef4","cross_cats_sorted":["cond-mat.soft","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-09-10T17:44:20Z","title_canon_sha256":"05fd714c10142347c80da7fe418c234ab2712759182e95d26bd27b23d2e91105"},"schema_version":"1.0","source":{"id":"1809.03472","kind":"arxiv","version":1}},"canonical_sha256":"77a45fa3e68fbd912e7a03e99b37dc63287e2130cbc083c4cdd371ec96bb439c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"77a45fa3e68fbd912e7a03e99b37dc63287e2130cbc083c4cdd371ec96bb439c","first_computed_at":"2026-05-18T00:06:06.801708Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:06:06.801708Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"D+T9d1EwFnjsEeyyGfmJwp4Aqs4YDBS4dbQtTbX0dc59awSwSvguAcmrq8hMsADSXysorgSFxPTGhPqKlixWBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:06:06.802268Z","signed_message":"canonical_sha256_bytes"},"source_id":"1809.03472","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:640836732afb6e215d043529ee937209a35e952a0d8502942df582e1ec200bf7","sha256:13da87cb96ec75d2df8921e98423f1ea9e5e6086cb7b488c1af6a4c6ce9241a1"],"state_sha256":"04c9c2d15845a1be479109d42ea110ddeb5e231e63ec939ad07dcb694eef7850"}