{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:OB5GPK7M7EIGDNHHKO6BDJP7JF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"62ff43e51cf8720b3b7e8b2bf2ef5d592543aa257f573f3cf80fc97e61d7ee06","cross_cats_sorted":["cond-mat.soft","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-08-02T21:53:09Z","title_canon_sha256":"1d41f06d6c213e8de77840d92f32512e37aee79499e9114c39b0625375814eee"},"schema_version":"1.0","source":{"id":"2508.01501","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.01501","created_at":"2026-07-05T12:09:22Z"},{"alias_kind":"arxiv_version","alias_value":"2508.01501v2","created_at":"2026-07-05T12:09:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.01501","created_at":"2026-07-05T12:09:22Z"},{"alias_kind":"pith_short_12","alias_value":"OB5GPK7M7EIG","created_at":"2026-07-05T12:09:22Z"},{"alias_kind":"pith_short_16","alias_value":"OB5GPK7M7EIGDNHH","created_at":"2026-07-05T12:09:22Z"},{"alias_kind":"pith_short_8","alias_value":"OB5GPK7M","created_at":"2026-07-05T12:09:22Z"}],"graph_snapshots":[{"event_id":"sha256:725c743ccb9ead5cca5fe85b6e88b9573043df218cba457b27ea0b54599ee25b","target":"graph","created_at":"2026-07-05T12:09:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.01501/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"We introduce RinQ, a hybrid quantum-classical framework for identifying functionally critical residues in proteins by formulating centrality detection as a Quadratic Unconstrained Binary Optimization (QUBO) problem. Protein structures are modeled as residue interaction networks (RINs), and the QUBO formulations are solved using D-Wave's simulated annealing. Applied to a diverse set of proteins, RinQ consistently identifies central residues that closely align with classical benchmarks, demonstrating both the accuracy and robustness of the approach.","authors_text":"Shah Ishmam Mohtashim","cross_cats":["cond-mat.soft","physics.bio-ph","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-08-02T21:53:09Z","title":"RinQ: Towards predicting central sites in proteins on current quantum computers"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.01501","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d92c0cb3b47055b070d9bbf0fae9c3dc355fbd9c74411b37e9d40e953d838357","target":"record","created_at":"2026-07-05T12:09:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"62ff43e51cf8720b3b7e8b2bf2ef5d592543aa257f573f3cf80fc97e61d7ee06","cross_cats_sorted":["cond-mat.soft","physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-08-02T21:53:09Z","title_canon_sha256":"1d41f06d6c213e8de77840d92f32512e37aee79499e9114c39b0625375814eee"},"schema_version":"1.0","source":{"id":"2508.01501","kind":"arxiv","version":2}},"canonical_sha256":"707a67abecf91061b4e753bc11a5ff4944b3e93d8aef4f7fc5cb61527afae670","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"707a67abecf91061b4e753bc11a5ff4944b3e93d8aef4f7fc5cb61527afae670","first_computed_at":"2026-07-05T12:09:22.144342Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:09:22.144342Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1Z2hgDg+RVhFeeV25YXTvKcjePB0W1yBoSCgcssE8V4S0egV5J9VMn5jGo2h7T0ZdX5tXfobfeXhl9zPE1rkBA==","signature_status":"signed_v1","signed_at":"2026-07-05T12:09:22.144839Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.01501","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d92c0cb3b47055b070d9bbf0fae9c3dc355fbd9c74411b37e9d40e953d838357","sha256:725c743ccb9ead5cca5fe85b6e88b9573043df218cba457b27ea0b54599ee25b"],"state_sha256":"bcad66ebe7685b04e92e76a7dcc07e7d7b254102c1530849677b13a5ce2d6eab"}