{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:OCAP6ZHJTFRMVITAJKGW5SACUN","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fd58e2ed61de9964441bba7c44c403678fc9a7344b303b6ff187c7b1c21af9f7","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2012-07-05T15:36:20Z","title_canon_sha256":"b01fc9f3b5981224df1b4f50a8ddf70bb041803fd2d41bd739ee65af835cb1f6"},"schema_version":"1.0","source":{"id":"1207.1288","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1207.1288","created_at":"2026-05-18T01:56:34Z"},{"alias_kind":"arxiv_version","alias_value":"1207.1288v1","created_at":"2026-05-18T01:56:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1207.1288","created_at":"2026-05-18T01:56:34Z"},{"alias_kind":"pith_short_12","alias_value":"OCAP6ZHJTFRM","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_16","alias_value":"OCAP6ZHJTFRMVITA","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_8","alias_value":"OCAP6ZHJ","created_at":"2026-05-18T12:27:16Z"}],"graph_snapshots":[{"event_id":"sha256:9be29871c8d53b2f7df01f05c3a829a57cc18efc5ab0c520544d8730c69b6fd2","target":"graph","created_at":"2026-05-18T01:56:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The atomistic characterization of the transition state is a fundamental step to improve the understanding of the folding mechanism and the function of proteins. From a computational point of view, the identification of the conformations that build out the transition state is particularly cumbersome, mainly because of the large computational cost of generating a statistically-sound set of folding trajectories. Here we show that a biasing algorithm, based on the physics of the ratchet-and-pawl, can be used to identify efficiently the transition state. The basic idea is that the algorithmic ratch","authors_text":"Carlo Camilloni, Guido Tiana","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2012-07-05T15:36:20Z","title":"Ratcheted molecular-dynamics simulations identify efficiently the transition state of protein folding"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1207.1288","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c70094761d0fa19ba86c119389f05b75c4a224006f77775ee9637e150b51cda6","target":"record","created_at":"2026-05-18T01:56:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fd58e2ed61de9964441bba7c44c403678fc9a7344b303b6ff187c7b1c21af9f7","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2012-07-05T15:36:20Z","title_canon_sha256":"b01fc9f3b5981224df1b4f50a8ddf70bb041803fd2d41bd739ee65af835cb1f6"},"schema_version":"1.0","source":{"id":"1207.1288","kind":"arxiv","version":1}},"canonical_sha256":"7080ff64e99962caa2604a8d6ec802a34c02fa67c31e7e37dc1cde409a0730a0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7080ff64e99962caa2604a8d6ec802a34c02fa67c31e7e37dc1cde409a0730a0","first_computed_at":"2026-05-18T01:56:34.280152Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:56:34.280152Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bLduWPDE14gaziANqo6z2zFY/cFC+TTh3t6jokn/yobaCPftXy7/QTwSmRr2NABdXUWkfYRV7uTvuGwMdMHjDw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:56:34.280841Z","signed_message":"canonical_sha256_bytes"},"source_id":"1207.1288","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c70094761d0fa19ba86c119389f05b75c4a224006f77775ee9637e150b51cda6","sha256:9be29871c8d53b2f7df01f05c3a829a57cc18efc5ab0c520544d8730c69b6fd2"],"state_sha256":"31c1c31afe565e79d89a994e3a540c7344ff69342a31e5410fd5dbefe2f622f2"}