{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2020:OD5QGUHUEONV4MCB3IUHOGPFHE","short_pith_number":"pith:OD5QGUHU","canonical_record":{"source":{"id":"2009.14354","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2020-09-30T00:17:53Z","cross_cats_sorted":[],"title_canon_sha256":"77f4ea786b34df94de68733c3866fa8287298b190c3d798cd462317bb3ff187d","abstract_canon_sha256":"fb415c0fae5307f6bb210e023b04d3035923cb8613a5fec99a8a032bda060053"},"schema_version":"1.0"},"canonical_sha256":"70fb0350f4239b5e3041da287719e53935eaa5b6cb2cab5acf1b27486fff46a2","source":{"kind":"arxiv","id":"2009.14354","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2009.14354","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"arxiv_version","alias_value":"2009.14354v2","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2009.14354","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_12","alias_value":"OD5QGUHUEONV","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_16","alias_value":"OD5QGUHUEONV4MCB","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_8","alias_value":"OD5QGUHU","created_at":"2026-07-05T02:04:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2020:OD5QGUHUEONV4MCB3IUHOGPFHE","target":"record","payload":{"canonical_record":{"source":{"id":"2009.14354","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2020-09-30T00:17:53Z","cross_cats_sorted":[],"title_canon_sha256":"77f4ea786b34df94de68733c3866fa8287298b190c3d798cd462317bb3ff187d","abstract_canon_sha256":"fb415c0fae5307f6bb210e023b04d3035923cb8613a5fec99a8a032bda060053"},"schema_version":"1.0"},"canonical_sha256":"70fb0350f4239b5e3041da287719e53935eaa5b6cb2cab5acf1b27486fff46a2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:04:11.641501Z","signature_b64":"N8yv2RXb32PJGbrVq4mrJj8I4XEE8yZkWNc3EgXZnrfL7PU5zc3Q1ovP4FB9sBStBTjxF4VGV8w7xlxof4cHBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"70fb0350f4239b5e3041da287719e53935eaa5b6cb2cab5acf1b27486fff46a2","last_reissued_at":"2026-07-05T02:04:11.641029Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:04:11.641029Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2009.14354","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:04:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ulFnDibzZtiABUiJRJuxEE8tSB3jbfTBNcK9B/qbiOlKNlso6cx97U7TEjjl1l6FhSsZQeqc9OsSUS5RG3lFDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T15:53:36.773889Z"},"content_sha256":"81f675a8dcdeedf5a4e97fec6bae8b10895a3d77b078c427112cea87e7e0a1d5","schema_version":"1.0","event_id":"sha256:81f675a8dcdeedf5a4e97fec6bae8b10895a3d77b078c427112cea87e7e0a1d5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2020:OD5QGUHUEONV4MCB3IUHOGPFHE","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Skewed Thermodynamic Geometry and Optimal Free Energy Estimation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.stat-mech","authors_text":"David A. Sivak, Steven Blaber","submitted_at":"2020-09-30T00:17:53Z","abstract_excerpt":"Free energy differences are a central quantity of interest in physics, chemistry, and biology. We develop design principles that improve the precision and accuracy of free energy estimators, which has potential applications to screening for targeted drug discovery. Specifically, by exploiting the connection between the work statistics of time-reversed protocol pairs, we develop near-equilibrium approximations for moments of the excess work and analyze the dominant contributions to the precision and accuracy of standard nonequilibrium free-energy estimators. Within linear response, minimum-diss"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2009.14354","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2009.14354/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:04:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"x/0ip2VX5/apnlgi8+PdwQux+vASb5BHOGcD5rxg2Cy9IaE/q986PaJvsaSUsYqTjqP/0Tic+s+oR8yRqLHSDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T15:53:36.774378Z"},"content_sha256":"5696ce747cb93babad260e32adb75908ae9c28384ca203920513aa7a15e14798","schema_version":"1.0","event_id":"sha256:5696ce747cb93babad260e32adb75908ae9c28384ca203920513aa7a15e14798"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/bundle.json","state_url":"https://pith.science/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-03T15:53:36Z","links":{"resolver":"https://pith.science/pith/OD5QGUHUEONV4MCB3IUHOGPFHE","bundle":"https://pith.science/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/bundle.json","state":"https://pith.science/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OD5QGUHUEONV4MCB3IUHOGPFHE/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:OD5QGUHUEONV4MCB3IUHOGPFHE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fb415c0fae5307f6bb210e023b04d3035923cb8613a5fec99a8a032bda060053","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2020-09-30T00:17:53Z","title_canon_sha256":"77f4ea786b34df94de68733c3866fa8287298b190c3d798cd462317bb3ff187d"},"schema_version":"1.0","source":{"id":"2009.14354","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2009.14354","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"arxiv_version","alias_value":"2009.14354v2","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2009.14354","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_12","alias_value":"OD5QGUHUEONV","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_16","alias_value":"OD5QGUHUEONV4MCB","created_at":"2026-07-05T02:04:11Z"},{"alias_kind":"pith_short_8","alias_value":"OD5QGUHU","created_at":"2026-07-05T02:04:11Z"}],"graph_snapshots":[{"event_id":"sha256:5696ce747cb93babad260e32adb75908ae9c28384ca203920513aa7a15e14798","target":"graph","created_at":"2026-07-05T02:04:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2009.14354/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Free energy differences are a central quantity of interest in physics, chemistry, and biology. We develop design principles that improve the precision and accuracy of free energy estimators, which has potential applications to screening for targeted drug discovery. Specifically, by exploiting the connection between the work statistics of time-reversed protocol pairs, we develop near-equilibrium approximations for moments of the excess work and analyze the dominant contributions to the precision and accuracy of standard nonequilibrium free-energy estimators. Within linear response, minimum-diss","authors_text":"David A. Sivak, Steven Blaber","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2020-09-30T00:17:53Z","title":"Skewed Thermodynamic Geometry and Optimal Free Energy Estimation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2009.14354","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:81f675a8dcdeedf5a4e97fec6bae8b10895a3d77b078c427112cea87e7e0a1d5","target":"record","created_at":"2026-07-05T02:04:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fb415c0fae5307f6bb210e023b04d3035923cb8613a5fec99a8a032bda060053","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2020-09-30T00:17:53Z","title_canon_sha256":"77f4ea786b34df94de68733c3866fa8287298b190c3d798cd462317bb3ff187d"},"schema_version":"1.0","source":{"id":"2009.14354","kind":"arxiv","version":2}},"canonical_sha256":"70fb0350f4239b5e3041da287719e53935eaa5b6cb2cab5acf1b27486fff46a2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"70fb0350f4239b5e3041da287719e53935eaa5b6cb2cab5acf1b27486fff46a2","first_computed_at":"2026-07-05T02:04:11.641029Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:04:11.641029Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"N8yv2RXb32PJGbrVq4mrJj8I4XEE8yZkWNc3EgXZnrfL7PU5zc3Q1ovP4FB9sBStBTjxF4VGV8w7xlxof4cHBg==","signature_status":"signed_v1","signed_at":"2026-07-05T02:04:11.641501Z","signed_message":"canonical_sha256_bytes"},"source_id":"2009.14354","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:81f675a8dcdeedf5a4e97fec6bae8b10895a3d77b078c427112cea87e7e0a1d5","sha256:5696ce747cb93babad260e32adb75908ae9c28384ca203920513aa7a15e14798"],"state_sha256":"d8944de5723a685246034d3e71143d11504742c8a03076fb9db91a97cc595997"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vgKE7OhcMcYU/qZf/0LBJcukae00Ev0PNhkMto/K/xsdLifRxJOwGNCIsw+yYa+OuGc10yK6Try0fV35zNluCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-03T15:53:36.778127Z","bundle_sha256":"1467ffc5835ac217a397589e3897f83abfe2f0d8c25297463fb458d43dc797fe"}}