{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:OD7CJWKL4BSIQHVTGLVFGEFMEZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a427c19e3af81d3a9a3519a2ec6239f65756b44f26e791874b7a8641b2d67646","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-02-08T13:23:16Z","title_canon_sha256":"a1114fbf4348d4e2c5646c784743e08e2b2ed93e8c7122846d0d04aea4d6ab85"},"schema_version":"1.0","source":{"id":"2502.05563","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.05563","created_at":"2026-07-05T10:11:40Z"},{"alias_kind":"arxiv_version","alias_value":"2502.05563v1","created_at":"2026-07-05T10:11:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.05563","created_at":"2026-07-05T10:11:40Z"},{"alias_kind":"pith_short_12","alias_value":"OD7CJWKL4BSI","created_at":"2026-07-05T10:11:40Z"},{"alias_kind":"pith_short_16","alias_value":"OD7CJWKL4BSIQHVT","created_at":"2026-07-05T10:11:40Z"},{"alias_kind":"pith_short_8","alias_value":"OD7CJWKL","created_at":"2026-07-05T10:11:40Z"}],"graph_snapshots":[{"event_id":"sha256:60d70a836ce42ac9342c4da061b2e36e8a98ad9bd309c2765f22d0e07fecad92","target":"graph","created_at":"2026-07-05T10:11:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.05563/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Monoclonal antibodies (mAb) represent an important class of biologic therapeutics that can treat a variety of diseases including cancer, autoimmune disorders or respiratory conditions (e.g. COVID-19). However, throughout their development, mAb are exposed to air-water or oil-water interfaces that may trigger mAb partial unfolding that can lead to the formation of proteinaceous aggregates. Using a combination of dynamic surface tensiometry and spatially resolved 1D 1H NMR spectroscopy, this study investigates if adsorption of a model IgG2a-\\k{appa} mAb to the oil-water interface affects its str","authors_text":"Hadi Mohammadigoushki, Jamini Bhagu, Lissa C. Anderson, Samuel C. Grant","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-02-08T13:23:16Z","title":"Nuclear Magnetic Resonance Study of Monoclonal Antibodies Near an Oil-Water Interface"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.05563","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:45ee48e6a7c106f0730fd0b143f8edec88b4f32844ca62e2b7d8402e95a785d6","target":"record","created_at":"2026-07-05T10:11:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a427c19e3af81d3a9a3519a2ec6239f65756b44f26e791874b7a8641b2d67646","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2025-02-08T13:23:16Z","title_canon_sha256":"a1114fbf4348d4e2c5646c784743e08e2b2ed93e8c7122846d0d04aea4d6ab85"},"schema_version":"1.0","source":{"id":"2502.05563","kind":"arxiv","version":1}},"canonical_sha256":"70fe24d94be064881eb332ea5310ac267fcaad4cb8ecc24276fc97765498bc0d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"70fe24d94be064881eb332ea5310ac267fcaad4cb8ecc24276fc97765498bc0d","first_computed_at":"2026-07-05T10:11:40.027206Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:11:40.027206Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aXwJcg6cZqgF8/ET1w7edwX5XR9dTlLvjgUAd/ohP5wsFThmMeOuD5qOb+QeQZbA9Uoy2mAhoxrnPByqH7RTDA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:11:40.027643Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.05563","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:45ee48e6a7c106f0730fd0b143f8edec88b4f32844ca62e2b7d8402e95a785d6","sha256:60d70a836ce42ac9342c4da061b2e36e8a98ad9bd309c2765f22d0e07fecad92"],"state_sha256":"8e47412c69dc48d4669c3ddbb40fa2f51ca1cc25ccf093904490727380d6352f"}