{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:OF45GGFUYT46SSQD4ROJDGJ6SR","short_pith_number":"pith:OF45GGFU","schema_version":"1.0","canonical_sha256":"7179d318b4c4f9e94a03e45c91993e94743a22f7a0219cd7ec2692deda683e08","source":{"kind":"arxiv","id":"1606.00054","version":2},"attestation_state":"computed","paper":{"title":"Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Bernhard O. Palsson, Ding Ma, Ines Thiele, Laurence Yang, Michael A. Saunders, Ronan M. T. Fleming","submitted_at":"2016-05-31T21:38:04Z","abstract_excerpt":"Constraint-Based Reconstruction and Analysis (COBRA) is currently the only methodology that permits integrated modeling of Metabolism and macromolecular Expression (ME) at genome-scale. Linear optimization computes steady-state flux solutions to ME models, but flux values are spread over many orders of magnitude. Standard double-precision solvers may return inaccurate solutions or report that no solution exists. Exact simplex solvers are extremely slow and hence not practical for ME models that currently have 70,000 constraints and variables and will grow larger. We have developed a quadruple-"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1606.00054","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-05-31T21:38:04Z","cross_cats_sorted":[],"title_canon_sha256":"d6892a39dfbf29ddb909715f37fd21ad158fd50c6547e2864d4f48ed6f87ee24","abstract_canon_sha256":"8b094163d15575fb4156d905f2f2aaaeeeb140144bf160424ab1a60c4f0eeb6b"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:03:49.679682Z","signature_b64":"J+9Di80qdbCrAGH7ahmcdjZPXwBtIbDMFJGgy/n330lGWI5i8dE4B1GLbCqaprF1TM4m7o3bbecF1YYENnJFDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7179d318b4c4f9e94a03e45c91993e94743a22f7a0219cd7ec2692deda683e08","last_reissued_at":"2026-05-18T01:03:49.679166Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:03:49.679166Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Bernhard O. Palsson, Ding Ma, Ines Thiele, Laurence Yang, Michael A. Saunders, Ronan M. T. Fleming","submitted_at":"2016-05-31T21:38:04Z","abstract_excerpt":"Constraint-Based Reconstruction and Analysis (COBRA) is currently the only methodology that permits integrated modeling of Metabolism and macromolecular Expression (ME) at genome-scale. Linear optimization computes steady-state flux solutions to ME models, but flux values are spread over many orders of magnitude. Standard double-precision solvers may return inaccurate solutions or report that no solution exists. Exact simplex solvers are extremely slow and hence not practical for ME models that currently have 70,000 constraints and variables and will grow larger. We have developed a quadruple-"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.00054","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1606.00054","created_at":"2026-05-18T01:03:49.679236+00:00"},{"alias_kind":"arxiv_version","alias_value":"1606.00054v2","created_at":"2026-05-18T01:03:49.679236+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.00054","created_at":"2026-05-18T01:03:49.679236+00:00"},{"alias_kind":"pith_short_12","alias_value":"OF45GGFUYT46","created_at":"2026-05-18T12:30:36.002864+00:00"},{"alias_kind":"pith_short_16","alias_value":"OF45GGFUYT46SSQD","created_at":"2026-05-18T12:30:36.002864+00:00"},{"alias_kind":"pith_short_8","alias_value":"OF45GGFU","created_at":"2026-05-18T12:30:36.002864+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR","json":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR.json","graph_json":"https://pith.science/api/pith-number/OF45GGFUYT46SSQD4ROJDGJ6SR/graph.json","events_json":"https://pith.science/api/pith-number/OF45GGFUYT46SSQD4ROJDGJ6SR/events.json","paper":"https://pith.science/paper/OF45GGFU"},"agent_actions":{"view_html":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR","download_json":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR.json","view_paper":"https://pith.science/paper/OF45GGFU","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1606.00054&json=true","fetch_graph":"https://pith.science/api/pith-number/OF45GGFUYT46SSQD4ROJDGJ6SR/graph.json","fetch_events":"https://pith.science/api/pith-number/OF45GGFUYT46SSQD4ROJDGJ6SR/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR/action/timestamp_anchor","attest_storage":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR/action/storage_attestation","attest_author":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR/action/author_attestation","sign_citation":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR/action/citation_signature","submit_replication":"https://pith.science/pith/OF45GGFUYT46SSQD4ROJDGJ6SR/action/replication_record"}},"created_at":"2026-05-18T01:03:49.679236+00:00","updated_at":"2026-05-18T01:03:49.679236+00:00"}