{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:OFDU4PKU5PWUS45UZADHOYR7AT","short_pith_number":"pith:OFDU4PKU","canonical_record":{"source":{"id":"1705.08327","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-05-19T20:47:57Z","cross_cats_sorted":[],"title_canon_sha256":"8839385480d92d3c55f692d56a129defe479cba6c7cfa52c72dd217fe3f56876","abstract_canon_sha256":"9b7723c39474f1a8720e1374788ff3c9d9f3e0c99d023398f417d48baff40988"},"schema_version":"1.0"},"canonical_sha256":"71474e3d54ebed4973b4c80677623f04cae44904e8680224c2f4c3a8fe37f210","source":{"kind":"arxiv","id":"1705.08327","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1705.08327","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"arxiv_version","alias_value":"1705.08327v1","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1705.08327","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"pith_short_12","alias_value":"OFDU4PKU5PWU","created_at":"2026-05-18T12:31:34Z"},{"alias_kind":"pith_short_16","alias_value":"OFDU4PKU5PWUS45U","created_at":"2026-05-18T12:31:34Z"},{"alias_kind":"pith_short_8","alias_value":"OFDU4PKU","created_at":"2026-05-18T12:31:34Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:OFDU4PKU5PWUS45UZADHOYR7AT","target":"record","payload":{"canonical_record":{"source":{"id":"1705.08327","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-05-19T20:47:57Z","cross_cats_sorted":[],"title_canon_sha256":"8839385480d92d3c55f692d56a129defe479cba6c7cfa52c72dd217fe3f56876","abstract_canon_sha256":"9b7723c39474f1a8720e1374788ff3c9d9f3e0c99d023398f417d48baff40988"},"schema_version":"1.0"},"canonical_sha256":"71474e3d54ebed4973b4c80677623f04cae44904e8680224c2f4c3a8fe37f210","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:43:48.591928Z","signature_b64":"eyb7x9vUu6uIZ5mNT2/XIDU/WjbByzZQS3saNclfU0bKKTiCPruTbMWKH/2uh29Sna9tHyZkDJNZHGLVsdxoDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"71474e3d54ebed4973b4c80677623f04cae44904e8680224c2f4c3a8fe37f210","last_reissued_at":"2026-05-18T00:43:48.591381Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:43:48.591381Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1705.08327","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:43:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3/RDFh8yy7e9+HprQVibbuPks+kIlq3bTxuwUaERWbr9NxtltwJx/2K+iQubulK13cGmNL6vD5niDifiobKHCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:04:09.972784Z"},"content_sha256":"5d0b2c1760a0e02a420e7506a403b435935f922ad3e8a8b32b7ab3aaf70d5241","schema_version":"1.0","event_id":"sha256:5d0b2c1760a0e02a420e7506a403b435935f922ad3e8a8b32b7ab3aaf70d5241"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:OFDU4PKU5PWUS45UZADHOYR7AT","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.CB","authors_text":"Alexandre de Castro, Carlos Frederico Fronza, Domingos Alves","submitted_at":"2017-05-19T20:47:57Z","abstract_excerpt":"Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to challenging problems of modern computing (MONROY, SAAB, GODINEZ, 2004). Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (LundegaarD, Lund, Kesmir, Brunak, Nielsen, 2007).In this article we studied in machina a approac"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.08327","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:43:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ENtVAgqAKqUnphIKaX7VQ0WY1S+CgjdIwYFPideQvsAVvI+oGnTG7Z9mYzOX682XM11Dz15kf5nBcLTifk6rDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:04:09.973137Z"},"content_sha256":"c1fe3c4f47dd42a958516eb9996c987cd2cd66b3b894498df0c266e7dd72a201","schema_version":"1.0","event_id":"sha256:c1fe3c4f47dd42a958516eb9996c987cd2cd66b3b894498df0c266e7dd72a201"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OFDU4PKU5PWUS45UZADHOYR7AT/bundle.json","state_url":"https://pith.science/pith/OFDU4PKU5PWUS45UZADHOYR7AT/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OFDU4PKU5PWUS45UZADHOYR7AT/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T04:04:09Z","links":{"resolver":"https://pith.science/pith/OFDU4PKU5PWUS45UZADHOYR7AT","bundle":"https://pith.science/pith/OFDU4PKU5PWUS45UZADHOYR7AT/bundle.json","state":"https://pith.science/pith/OFDU4PKU5PWUS45UZADHOYR7AT/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OFDU4PKU5PWUS45UZADHOYR7AT/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:OFDU4PKU5PWUS45UZADHOYR7AT","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9b7723c39474f1a8720e1374788ff3c9d9f3e0c99d023398f417d48baff40988","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-05-19T20:47:57Z","title_canon_sha256":"8839385480d92d3c55f692d56a129defe479cba6c7cfa52c72dd217fe3f56876"},"schema_version":"1.0","source":{"id":"1705.08327","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1705.08327","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"arxiv_version","alias_value":"1705.08327v1","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1705.08327","created_at":"2026-05-18T00:43:48Z"},{"alias_kind":"pith_short_12","alias_value":"OFDU4PKU5PWU","created_at":"2026-05-18T12:31:34Z"},{"alias_kind":"pith_short_16","alias_value":"OFDU4PKU5PWUS45U","created_at":"2026-05-18T12:31:34Z"},{"alias_kind":"pith_short_8","alias_value":"OFDU4PKU","created_at":"2026-05-18T12:31:34Z"}],"graph_snapshots":[{"event_id":"sha256:c1fe3c4f47dd42a958516eb9996c987cd2cd66b3b894498df0c266e7dd72a201","target":"graph","created_at":"2026-05-18T00:43:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Immunological systems have been an abundant inspiration to contemporary computer scientists. Problem solving strategies, stemming from known immune system phenomena, have been successfully applied to challenging problems of modern computing (MONROY, SAAB, GODINEZ, 2004). Simulation systems and mathematical modeling are also beginning use to answer more complex immunological questions as immune memory process and duration of vaccines, where the regulation mechanisms are not still known sufficiently (LundegaarD, Lund, Kesmir, Brunak, Nielsen, 2007).In this article we studied in machina a approac","authors_text":"Alexandre de Castro, Carlos Frederico Fronza, Domingos Alves","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-05-19T20:47:57Z","title":"A dynamical modeling to study the adaptive immune system and the influence of antibodies in the immune memory"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1705.08327","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5d0b2c1760a0e02a420e7506a403b435935f922ad3e8a8b32b7ab3aaf70d5241","target":"record","created_at":"2026-05-18T00:43:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9b7723c39474f1a8720e1374788ff3c9d9f3e0c99d023398f417d48baff40988","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2017-05-19T20:47:57Z","title_canon_sha256":"8839385480d92d3c55f692d56a129defe479cba6c7cfa52c72dd217fe3f56876"},"schema_version":"1.0","source":{"id":"1705.08327","kind":"arxiv","version":1}},"canonical_sha256":"71474e3d54ebed4973b4c80677623f04cae44904e8680224c2f4c3a8fe37f210","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"71474e3d54ebed4973b4c80677623f04cae44904e8680224c2f4c3a8fe37f210","first_computed_at":"2026-05-18T00:43:48.591381Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:43:48.591381Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"eyb7x9vUu6uIZ5mNT2/XIDU/WjbByzZQS3saNclfU0bKKTiCPruTbMWKH/2uh29Sna9tHyZkDJNZHGLVsdxoDA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:43:48.591928Z","signed_message":"canonical_sha256_bytes"},"source_id":"1705.08327","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5d0b2c1760a0e02a420e7506a403b435935f922ad3e8a8b32b7ab3aaf70d5241","sha256:c1fe3c4f47dd42a958516eb9996c987cd2cd66b3b894498df0c266e7dd72a201"],"state_sha256":"8df4368286017ebba4607034202ccf726c04693ad4fbb2f721c3762721dde350"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dx4VUTxqJy8hNIv8eknwMLkkBQXTjj2zxhkqpix5PpoK4rNSNbHOcxhcy4fm4pNYZ2/euHDSVtscsAOzwOJBDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T04:04:09.975195Z","bundle_sha256":"c4c7f19193d6f9d5c548fba663d8d11dd33b0dceb4381defb6468b8f738e5a51"}}