{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:OGJNH2WTO4AXEJAQ3JXCWBMGUO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"118557c4baadaf418cd493553831921d1a1c244cf3088f0bdef8e6cfda6af77e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-03-28T07:05:10Z","title_canon_sha256":"70a95363170b74ac2ad56f52bec211fb846afd2d780511ae54d37d9b7a738c77"},"schema_version":"1.0","source":{"id":"1503.08274","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.08274","created_at":"2026-05-18T02:20:02Z"},{"alias_kind":"arxiv_version","alias_value":"1503.08274v1","created_at":"2026-05-18T02:20:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.08274","created_at":"2026-05-18T02:20:02Z"},{"alias_kind":"pith_short_12","alias_value":"OGJNH2WTO4AX","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_16","alias_value":"OGJNH2WTO4AXEJAQ","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_8","alias_value":"OGJNH2WT","created_at":"2026-05-18T12:29:34Z"}],"graph_snapshots":[{"event_id":"sha256:7d535612123a7f4837afc60689c0a4eb46f6596fd3335bc280fc9a8903c4ff5a","target":"graph","created_at":"2026-05-18T02:20:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The tumor suppressor p53 plays a central role in cell fate decisions after DNA damage. Programmed Cell Death 5 (PDCD5) is known to interact with the p53 pathway to promote cell apoptosis. Recombinant human PDCD5 can significantly sensitize different cancers to chemotherapies. In the present paper, we construct a computational model that includes PDCD5 interactions in the p53 signaling network and study the effects of PDCD5 on p53-mediated cell fate decisions during the DNA damage response. Our results revealed that PDCD5 functions as a co-activator of p53 that regulates p53-dependent cell fate","authors_text":"Changjing Zhuge, Jinzhi Lei, Xiaojuan Sun, Yingyu Chen","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-03-28T07:05:10Z","title":"PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.08274","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:49f2bc615c9e579b3835b1732279c38501ced83690a3a273403f103995fb7fac","target":"record","created_at":"2026-05-18T02:20:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"118557c4baadaf418cd493553831921d1a1c244cf3088f0bdef8e6cfda6af77e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-03-28T07:05:10Z","title_canon_sha256":"70a95363170b74ac2ad56f52bec211fb846afd2d780511ae54d37d9b7a738c77"},"schema_version":"1.0","source":{"id":"1503.08274","kind":"arxiv","version":1}},"canonical_sha256":"7192d3ead37701722410da6e2b0586a3896e67072670b8596bcc29dae26ad91d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7192d3ead37701722410da6e2b0586a3896e67072670b8596bcc29dae26ad91d","first_computed_at":"2026-05-18T02:20:02.282260Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:20:02.282260Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Vriz9rq83/9ZCU9lfVb+0+QNbdrMppT9M9sEL3saIzpjzCp8EktRu05DcS6mvYY0CUQJKRglD4WG56OfqcReCg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:20:02.282852Z","signed_message":"canonical_sha256_bytes"},"source_id":"1503.08274","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:49f2bc615c9e579b3835b1732279c38501ced83690a3a273403f103995fb7fac","sha256:7d535612123a7f4837afc60689c0a4eb46f6596fd3335bc280fc9a8903c4ff5a"],"state_sha256":"7dae36c12387e8edbc598b32c54307991eb9bdc0adc77f759ea48186f25d15c4"}