{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:OGSAZ6MKE745SXPQ55O75QGBEM","short_pith_number":"pith:OGSAZ6MK","canonical_record":{"source":{"id":"2411.07317","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-11-11T19:19:46Z","cross_cats_sorted":[],"title_canon_sha256":"886e10647e39aceb9d6d7a3509089e700a5ad46433044c54b551ce6ae3b954a3","abstract_canon_sha256":"36f9bfecdb43d4fc10b430c7db6c260ef9ca6204e7dcc24b82e50f493257eb31"},"schema_version":"1.0"},"canonical_sha256":"71a40cf98a27f9d95df0ef5dfec0c12319141699f9ba9a9fcc1288c8c02f57e0","source":{"kind":"arxiv","id":"2411.07317","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.07317","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"arxiv_version","alias_value":"2411.07317v2","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.07317","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_12","alias_value":"OGSAZ6MKE745","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_16","alias_value":"OGSAZ6MKE745SXPQ","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_8","alias_value":"OGSAZ6MK","created_at":"2026-07-05T10:15:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:OGSAZ6MKE745SXPQ55O75QGBEM","target":"record","payload":{"canonical_record":{"source":{"id":"2411.07317","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-11-11T19:19:46Z","cross_cats_sorted":[],"title_canon_sha256":"886e10647e39aceb9d6d7a3509089e700a5ad46433044c54b551ce6ae3b954a3","abstract_canon_sha256":"36f9bfecdb43d4fc10b430c7db6c260ef9ca6204e7dcc24b82e50f493257eb31"},"schema_version":"1.0"},"canonical_sha256":"71a40cf98a27f9d95df0ef5dfec0c12319141699f9ba9a9fcc1288c8c02f57e0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:15:47.145754Z","signature_b64":"lo4NOw+TFzyhZEn95FhiQt95Z7sHz93QvrDA4NtSr4EffE9Yeqx31clZ8Xo/e8ruOkyst6F6heoeJHhi+q82AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"71a40cf98a27f9d95df0ef5dfec0c12319141699f9ba9a9fcc1288c8c02f57e0","last_reissued_at":"2026-07-05T10:15:47.145240Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:15:47.145240Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2411.07317","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:15:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"voUZGsGLno5ob6pu8PntqAyyuLX8hZ0rckZq7rGMdi7HkSAT9TMkOZ7mDLWSJoBdxlEsSBFSnw5ava17PrieDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T17:50:53.397943Z"},"content_sha256":"d41c094f54507a529136754292e8bf03d6d616daff1c09016e76f29a58e281ad","schema_version":"1.0","event_id":"sha256:d41c094f54507a529136754292e8bf03d6d616daff1c09016e76f29a58e281ad"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:OGSAZ6MKE745SXPQ55O75QGBEM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"SynRL: Aligning Synthetic Clinical Trial Data with Human-preferred Clinical Endpoints Using Reinforcement Learning","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cs.LG","authors_text":"Afrah Shafquat, Jacob Aptekar, Jason Mezey, Jimeng Sun, Mandis Beigi, Trisha Das, Zifeng Wang","submitted_at":"2024-11-11T19:19:46Z","abstract_excerpt":"Each year, hundreds of clinical trials are conducted to evaluate new medical interventions, but sharing patient records from these trials with other institutions can be challenging due to privacy concerns and federal regulations. To help mitigate privacy concerns, researchers have proposed methods for generating synthetic patient data. However, existing approaches for generating synthetic clinical trial data disregard the usage requirements of these data, including maintaining specific properties of clinical outcomes, and only use post hoc assessments that are not coupled with the data generat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.07317","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2411.07317/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:15:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fk0GiLdveSrqNmeCj/S0PfdGiKVrkAIhXTbdBWMN6Ei9wvljF4idXGQHYF7fsbo/FT6IHvNSlAYTeNvvcc2OBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T17:50:53.398823Z"},"content_sha256":"79135e2fba959ae4bf895b8fe4c536b999afaa1bc0dfa5b79bdf0ffbe8a3a10f","schema_version":"1.0","event_id":"sha256:79135e2fba959ae4bf895b8fe4c536b999afaa1bc0dfa5b79bdf0ffbe8a3a10f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OGSAZ6MKE745SXPQ55O75QGBEM/bundle.json","state_url":"https://pith.science/pith/OGSAZ6MKE745SXPQ55O75QGBEM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OGSAZ6MKE745SXPQ55O75QGBEM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T17:50:53Z","links":{"resolver":"https://pith.science/pith/OGSAZ6MKE745SXPQ55O75QGBEM","bundle":"https://pith.science/pith/OGSAZ6MKE745SXPQ55O75QGBEM/bundle.json","state":"https://pith.science/pith/OGSAZ6MKE745SXPQ55O75QGBEM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OGSAZ6MKE745SXPQ55O75QGBEM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:OGSAZ6MKE745SXPQ55O75QGBEM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"36f9bfecdb43d4fc10b430c7db6c260ef9ca6204e7dcc24b82e50f493257eb31","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-11-11T19:19:46Z","title_canon_sha256":"886e10647e39aceb9d6d7a3509089e700a5ad46433044c54b551ce6ae3b954a3"},"schema_version":"1.0","source":{"id":"2411.07317","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.07317","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"arxiv_version","alias_value":"2411.07317v2","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.07317","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_12","alias_value":"OGSAZ6MKE745","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_16","alias_value":"OGSAZ6MKE745SXPQ","created_at":"2026-07-05T10:15:47Z"},{"alias_kind":"pith_short_8","alias_value":"OGSAZ6MK","created_at":"2026-07-05T10:15:47Z"}],"graph_snapshots":[{"event_id":"sha256:79135e2fba959ae4bf895b8fe4c536b999afaa1bc0dfa5b79bdf0ffbe8a3a10f","target":"graph","created_at":"2026-07-05T10:15:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.07317/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Each year, hundreds of clinical trials are conducted to evaluate new medical interventions, but sharing patient records from these trials with other institutions can be challenging due to privacy concerns and federal regulations. To help mitigate privacy concerns, researchers have proposed methods for generating synthetic patient data. However, existing approaches for generating synthetic clinical trial data disregard the usage requirements of these data, including maintaining specific properties of clinical outcomes, and only use post hoc assessments that are not coupled with the data generat","authors_text":"Afrah Shafquat, Jacob Aptekar, Jason Mezey, Jimeng Sun, Mandis Beigi, Trisha Das, Zifeng Wang","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-11-11T19:19:46Z","title":"SynRL: Aligning Synthetic Clinical Trial Data with Human-preferred Clinical Endpoints Using Reinforcement Learning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.07317","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d41c094f54507a529136754292e8bf03d6d616daff1c09016e76f29a58e281ad","target":"record","created_at":"2026-07-05T10:15:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"36f9bfecdb43d4fc10b430c7db6c260ef9ca6204e7dcc24b82e50f493257eb31","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.LG","submitted_at":"2024-11-11T19:19:46Z","title_canon_sha256":"886e10647e39aceb9d6d7a3509089e700a5ad46433044c54b551ce6ae3b954a3"},"schema_version":"1.0","source":{"id":"2411.07317","kind":"arxiv","version":2}},"canonical_sha256":"71a40cf98a27f9d95df0ef5dfec0c12319141699f9ba9a9fcc1288c8c02f57e0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"71a40cf98a27f9d95df0ef5dfec0c12319141699f9ba9a9fcc1288c8c02f57e0","first_computed_at":"2026-07-05T10:15:47.145240Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:15:47.145240Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lo4NOw+TFzyhZEn95FhiQt95Z7sHz93QvrDA4NtSr4EffE9Yeqx31clZ8Xo/e8ruOkyst6F6heoeJHhi+q82AQ==","signature_status":"signed_v1","signed_at":"2026-07-05T10:15:47.145754Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.07317","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d41c094f54507a529136754292e8bf03d6d616daff1c09016e76f29a58e281ad","sha256:79135e2fba959ae4bf895b8fe4c536b999afaa1bc0dfa5b79bdf0ffbe8a3a10f"],"state_sha256":"9aea5a7127740d4c72f6fb7f7921724e9e8bef4b7a1ebdf0f948c72c218299f8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rPHIgnnkOrp+IsZRY36V8oKMhZnaTeetSlMdSUntsPZQeXHD1856cbNEk911T8+43PmoiBZ9urtjmX7LsJjECA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T17:50:53.404307Z","bundle_sha256":"36f066a8146c30dd63bdfb84c2873f44be501930c9c99fd96867ff51301f8a0c"}}