{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:OJZP7NQCHLTSMNTZDW2QCHEJMB","short_pith_number":"pith:OJZP7NQC","canonical_record":{"source":{"id":"2307.03757","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-07-06T19:11:00Z","cross_cats_sorted":["cs.CV","eess.IV"],"title_canon_sha256":"b9df2afce4d8a30af30f84a08366880f7e3aa1408975630ab0e56ba5fa760411","abstract_canon_sha256":"fa07c7ebb242edd21be00f90d4fd54269c57ca66b00a30ada3294e8ce809ea08"},"schema_version":"1.0"},"canonical_sha256":"7272ffb6023ae72636791db5011c89607172fc20f06599d5cc9cae72a780c433","source":{"kind":"arxiv","id":"2307.03757","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2307.03757","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"arxiv_version","alias_value":"2307.03757v1","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2307.03757","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_12","alias_value":"OJZP7NQCHLTS","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_16","alias_value":"OJZP7NQCHLTSMNTZ","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_8","alias_value":"OJZP7NQC","created_at":"2026-07-05T06:28:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:OJZP7NQCHLTSMNTZDW2QCHEJMB","target":"record","payload":{"canonical_record":{"source":{"id":"2307.03757","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-07-06T19:11:00Z","cross_cats_sorted":["cs.CV","eess.IV"],"title_canon_sha256":"b9df2afce4d8a30af30f84a08366880f7e3aa1408975630ab0e56ba5fa760411","abstract_canon_sha256":"fa07c7ebb242edd21be00f90d4fd54269c57ca66b00a30ada3294e8ce809ea08"},"schema_version":"1.0"},"canonical_sha256":"7272ffb6023ae72636791db5011c89607172fc20f06599d5cc9cae72a780c433","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T06:28:47.789276Z","signature_b64":"E6HVrUfoA35rccUvupRtSXN0JKBcT+QO7KNX2gXd7u1d0h5j9+n9Iq+Ck86qFqXIIpJ3P4WwRO4GOKMyDbSkBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7272ffb6023ae72636791db5011c89607172fc20f06599d5cc9cae72a780c433","last_reissued_at":"2026-07-05T06:28:47.788816Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T06:28:47.788816Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2307.03757","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T06:28:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Bxoj885ZKpAG2bTiH8awm5ViXZpaVMj1/wrwwP52XSG2axEal5bDRBwxY38kxE8x8kniqmNiKGI//jnUqsBhAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T06:52:08.288882Z"},"content_sha256":"ff736be7770e238aba970465c89632c8dd05c349a4a3b9c7aa74fa53e4ed2e0a","schema_version":"1.0","event_id":"sha256:ff736be7770e238aba970465c89632c8dd05c349a4a3b9c7aa74fa53e4ed2e0a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:OJZP7NQCHLTSMNTZDW2QCHEJMB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Fully Automated and Explainable Algorithm for the Prediction of Malignant Transformation in Oral Epithelial Dysplasia","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["cs.CV","eess.IV"],"primary_cat":"q-bio.QM","authors_text":"Adam J Shephard, Fayyaz Minhas, Hanya Mahmood, Hisham Mehanna, Jacqueline James, Jill Brooks, Kris D McCombe, Mostafa Jahanifar, Nasir M Rajpoot, Paul Nankivell, Raja Muhammad Saad Bashir, Shan E Ahmed Raza, Stephanie G Craig, Syed Ali Khurram","submitted_at":"2023-07-06T19:11:00Z","abstract_excerpt":"Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. Its grading suffers from significant inter-/intra- observer variability, and does not reliably predict malignancy progression, potentially leading to suboptimal treatment decisions. To address this, we developed a novel artificial intelligence algorithm that can assign an Oral Malignant Transformation (OMT) risk score, based on histological patterns in the in Haematoxylin and Eosin stained whole slide images, to quantify the risk of OED progression. The algorithm is based on the d"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2307.03757","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2307.03757/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T06:28:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AYwVxMbzCBHcRp5dTS7IcAUDViMxAWbl1IIZR3wMskTE3Dx3TOhE7S3c3cAYKhckXYFc3zsrFBopZE2jROxgBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T06:52:08.289262Z"},"content_sha256":"9ca5e1d14a16fb194ba27394d5262b25b201761cf089aa052f36dffdc27f9285","schema_version":"1.0","event_id":"sha256:9ca5e1d14a16fb194ba27394d5262b25b201761cf089aa052f36dffdc27f9285"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/bundle.json","state_url":"https://pith.science/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-07T06:52:08Z","links":{"resolver":"https://pith.science/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB","bundle":"https://pith.science/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/bundle.json","state":"https://pith.science/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OJZP7NQCHLTSMNTZDW2QCHEJMB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:OJZP7NQCHLTSMNTZDW2QCHEJMB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fa07c7ebb242edd21be00f90d4fd54269c57ca66b00a30ada3294e8ce809ea08","cross_cats_sorted":["cs.CV","eess.IV"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-07-06T19:11:00Z","title_canon_sha256":"b9df2afce4d8a30af30f84a08366880f7e3aa1408975630ab0e56ba5fa760411"},"schema_version":"1.0","source":{"id":"2307.03757","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2307.03757","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"arxiv_version","alias_value":"2307.03757v1","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2307.03757","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_12","alias_value":"OJZP7NQCHLTS","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_16","alias_value":"OJZP7NQCHLTSMNTZ","created_at":"2026-07-05T06:28:47Z"},{"alias_kind":"pith_short_8","alias_value":"OJZP7NQC","created_at":"2026-07-05T06:28:47Z"}],"graph_snapshots":[{"event_id":"sha256:9ca5e1d14a16fb194ba27394d5262b25b201761cf089aa052f36dffdc27f9285","target":"graph","created_at":"2026-07-05T06:28:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2307.03757/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity. Its grading suffers from significant inter-/intra- observer variability, and does not reliably predict malignancy progression, potentially leading to suboptimal treatment decisions. To address this, we developed a novel artificial intelligence algorithm that can assign an Oral Malignant Transformation (OMT) risk score, based on histological patterns in the in Haematoxylin and Eosin stained whole slide images, to quantify the risk of OED progression. The algorithm is based on the d","authors_text":"Adam J Shephard, Fayyaz Minhas, Hanya Mahmood, Hisham Mehanna, Jacqueline James, Jill Brooks, Kris D McCombe, Mostafa Jahanifar, Nasir M Rajpoot, Paul Nankivell, Raja Muhammad Saad Bashir, Shan E Ahmed Raza, Stephanie G Craig, Syed Ali Khurram","cross_cats":["cs.CV","eess.IV"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-07-06T19:11:00Z","title":"A Fully Automated and Explainable Algorithm for the Prediction of Malignant Transformation in Oral Epithelial Dysplasia"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2307.03757","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ff736be7770e238aba970465c89632c8dd05c349a4a3b9c7aa74fa53e4ed2e0a","target":"record","created_at":"2026-07-05T06:28:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fa07c7ebb242edd21be00f90d4fd54269c57ca66b00a30ada3294e8ce809ea08","cross_cats_sorted":["cs.CV","eess.IV"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2023-07-06T19:11:00Z","title_canon_sha256":"b9df2afce4d8a30af30f84a08366880f7e3aa1408975630ab0e56ba5fa760411"},"schema_version":"1.0","source":{"id":"2307.03757","kind":"arxiv","version":1}},"canonical_sha256":"7272ffb6023ae72636791db5011c89607172fc20f06599d5cc9cae72a780c433","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7272ffb6023ae72636791db5011c89607172fc20f06599d5cc9cae72a780c433","first_computed_at":"2026-07-05T06:28:47.788816Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T06:28:47.788816Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"E6HVrUfoA35rccUvupRtSXN0JKBcT+QO7KNX2gXd7u1d0h5j9+n9Iq+Ck86qFqXIIpJ3P4WwRO4GOKMyDbSkBw==","signature_status":"signed_v1","signed_at":"2026-07-05T06:28:47.789276Z","signed_message":"canonical_sha256_bytes"},"source_id":"2307.03757","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ff736be7770e238aba970465c89632c8dd05c349a4a3b9c7aa74fa53e4ed2e0a","sha256:9ca5e1d14a16fb194ba27394d5262b25b201761cf089aa052f36dffdc27f9285"],"state_sha256":"3ab774c969a25bc47d6b2ea0bdb3650d09b7094407f31e2d06cb9873e0d70f22"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eY9AZKVqdCzmkzRrOIaBHPXdp+kd5SX8FNTKGkU2J2+iX/nDaDOpalgtvg2oABGgbA3RPJ6qO0dkWp+sHW6HCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-07T06:52:08.291392Z","bundle_sha256":"de756a8dd7892ba2a78d99130aef35161deac8db50cce087940a715447dd143e"}}