{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2013:OLKC5KYPK4SDFLNI43VMB44IEJ","short_pith_number":"pith:OLKC5KYP","schema_version":"1.0","canonical_sha256":"72d42eab0f572432ada8e6eac0f38822719a7abbfc82406622ed57e1cc56c37c","source":{"kind":"arxiv","id":"1305.3634","version":1},"attestation_state":"computed","paper":{"title":"Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.CB","authors_text":"Kathleen P. Wilkie, Philip Hahnfeldt","submitted_at":"2013-05-15T20:58:57Z","abstract_excerpt":"Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor development and cancer dormancy. To study this biological phenomenon theoretically we construct a minimally parameterized framework that incorporates all aspects of the immune response. We combine the effects of all immune cell types, general principles of self-limited logistic growth, and the physical process of inflammation into one quantitative setting. Simulation"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1305.3634","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2013-05-15T20:58:57Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"11ce3e2027bf735707a66481c98b8f138ce3b1a9824bc19e0e267ffff8cb443d","abstract_canon_sha256":"37eab71dea927044d730bfaae2d4867056eb6fd5f12d51483eb8729dc3774e8d"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:25:34.289821Z","signature_b64":"dMtw73X8IF9JfF6XqvU+6We6VThwrZMSO6KCBW2aUpBNc3x2y21nfeynLMCDqqoowA9J5yglfvLUQBe/LHWOCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"72d42eab0f572432ada8e6eac0f38822719a7abbfc82406622ed57e1cc56c37c","last_reissued_at":"2026-05-18T03:25:34.288916Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:25:34.288916Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.CB","authors_text":"Kathleen P. Wilkie, Philip Hahnfeldt","submitted_at":"2013-05-15T20:58:57Z","abstract_excerpt":"Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing influences has complex implications for tumor development and cancer dormancy. To study this biological phenomenon theoretically we construct a minimally parameterized framework that incorporates all aspects of the immune response. We combine the effects of all immune cell types, general principles of self-limited logistic growth, and the physical process of inflammation into one quantitative setting. Simulation"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1305.3634","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1305.3634","created_at":"2026-05-18T03:25:34.289040+00:00"},{"alias_kind":"arxiv_version","alias_value":"1305.3634v1","created_at":"2026-05-18T03:25:34.289040+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1305.3634","created_at":"2026-05-18T03:25:34.289040+00:00"},{"alias_kind":"pith_short_12","alias_value":"OLKC5KYPK4SD","created_at":"2026-05-18T12:27:54.935989+00:00"},{"alias_kind":"pith_short_16","alias_value":"OLKC5KYPK4SDFLNI","created_at":"2026-05-18T12:27:54.935989+00:00"},{"alias_kind":"pith_short_8","alias_value":"OLKC5KYP","created_at":"2026-05-18T12:27:54.935989+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ","json":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ.json","graph_json":"https://pith.science/api/pith-number/OLKC5KYPK4SDFLNI43VMB44IEJ/graph.json","events_json":"https://pith.science/api/pith-number/OLKC5KYPK4SDFLNI43VMB44IEJ/events.json","paper":"https://pith.science/paper/OLKC5KYP"},"agent_actions":{"view_html":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ","download_json":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ.json","view_paper":"https://pith.science/paper/OLKC5KYP","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1305.3634&json=true","fetch_graph":"https://pith.science/api/pith-number/OLKC5KYPK4SDFLNI43VMB44IEJ/graph.json","fetch_events":"https://pith.science/api/pith-number/OLKC5KYPK4SDFLNI43VMB44IEJ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ/action/storage_attestation","attest_author":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ/action/author_attestation","sign_citation":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ/action/citation_signature","submit_replication":"https://pith.science/pith/OLKC5KYPK4SDFLNI43VMB44IEJ/action/replication_record"}},"created_at":"2026-05-18T03:25:34.289040+00:00","updated_at":"2026-05-18T03:25:34.289040+00:00"}