{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:OPAKF3QKI7ZR3KT66A6KVD6L6S","short_pith_number":"pith:OPAKF3QK","canonical_record":{"source":{"id":"1512.04184","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-14T06:06:02Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"f82c04862acc76583caa57404a3e2902af1d7bde58f83ee2ecb165d8abe1fe5c","abstract_canon_sha256":"2d7cdca0152e24855c27c5ba5f36749fd698fba3cb367afe7ec3b60b13a773af"},"schema_version":"1.0"},"canonical_sha256":"73c0a2ee0a47f31daa7ef03caa8fcbf482ec42bd1b3bffdbf01cd7cdbcff5e2a","source":{"kind":"arxiv","id":"1512.04184","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.04184","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"arxiv_version","alias_value":"1512.04184v3","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.04184","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"pith_short_12","alias_value":"OPAKF3QKI7ZR","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_16","alias_value":"OPAKF3QKI7ZR3KT6","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_8","alias_value":"OPAKF3QK","created_at":"2026-05-18T12:29:34Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:OPAKF3QKI7ZR3KT66A6KVD6L6S","target":"record","payload":{"canonical_record":{"source":{"id":"1512.04184","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-14T06:06:02Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"f82c04862acc76583caa57404a3e2902af1d7bde58f83ee2ecb165d8abe1fe5c","abstract_canon_sha256":"2d7cdca0152e24855c27c5ba5f36749fd698fba3cb367afe7ec3b60b13a773af"},"schema_version":"1.0"},"canonical_sha256":"73c0a2ee0a47f31daa7ef03caa8fcbf482ec42bd1b3bffdbf01cd7cdbcff5e2a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:10:52.442697Z","signature_b64":"77C8FQbzs/+DgX0Z1PZ3OpwYBToid9vohtWejW+8vqq2AuZxc7+7MiUYzGcaieFii3ETIdb9hhdUjHwHT9dnBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"73c0a2ee0a47f31daa7ef03caa8fcbf482ec42bd1b3bffdbf01cd7cdbcff5e2a","last_reissued_at":"2026-05-18T00:10:52.442055Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:10:52.442055Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.04184","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:10:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aZB2Au9mfari5Gt8DPm8giCAZPOz4e0lH8fwubFoWwOkcDrRXWnCpRQC2UOHB2vsREjUyEY7S5J4Qim1fOjjCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T12:15:45.990485Z"},"content_sha256":"736d11ade052c7fe1bc4957a9ab0fcad14fbd17e16642c8460b23b9c87ae7678","schema_version":"1.0","event_id":"sha256:736d11ade052c7fe1bc4957a9ab0fcad14fbd17e16642c8460b23b9c87ae7678"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:OPAKF3QKI7ZR3KT66A6KVD6L6S","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.TO","authors_text":"Andrew Pietersen, Kyung In Baek, Marcus Roper, Sheng-Ping L. Hwang, Shenyinying Tu, Shyr-Shea Chang, Tzung K. Hsiai, Van Savage, Yu-Hsiu Liu","submitted_at":"2015-12-14T06:06:02Z","abstract_excerpt":"In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.04184","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:10:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qXKqzHYkXp+8BrHFQ6q1RPdKqekcdbWHhVw7efVEVX3aRUq65Xsiv22nUNHagvfe3aBpZmzN9iTOZPvgAZJCDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T12:15:45.990833Z"},"content_sha256":"80e35381a3efed4db95fc3ca4fea09e6116f56fd2b5d871d01d2ef302544bf1e","schema_version":"1.0","event_id":"sha256:80e35381a3efed4db95fc3ca4fea09e6116f56fd2b5d871d01d2ef302544bf1e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/bundle.json","state_url":"https://pith.science/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T12:15:45Z","links":{"resolver":"https://pith.science/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S","bundle":"https://pith.science/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/bundle.json","state":"https://pith.science/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OPAKF3QKI7ZR3KT66A6KVD6L6S/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:OPAKF3QKI7ZR3KT66A6KVD6L6S","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2d7cdca0152e24855c27c5ba5f36749fd698fba3cb367afe7ec3b60b13a773af","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-14T06:06:02Z","title_canon_sha256":"f82c04862acc76583caa57404a3e2902af1d7bde58f83ee2ecb165d8abe1fe5c"},"schema_version":"1.0","source":{"id":"1512.04184","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.04184","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"arxiv_version","alias_value":"1512.04184v3","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.04184","created_at":"2026-05-18T00:10:52Z"},{"alias_kind":"pith_short_12","alias_value":"OPAKF3QKI7ZR","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_16","alias_value":"OPAKF3QKI7ZR3KT6","created_at":"2026-05-18T12:29:34Z"},{"alias_kind":"pith_short_8","alias_value":"OPAKF3QK","created_at":"2026-05-18T12:29:34Z"}],"graph_snapshots":[{"event_id":"sha256:80e35381a3efed4db95fc3ca4fea09e6116f56fd2b5d871d01d2ef302544bf1e","target":"graph","created_at":"2026-05-18T00:10:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the t","authors_text":"Andrew Pietersen, Kyung In Baek, Marcus Roper, Sheng-Ping L. Hwang, Shenyinying Tu, Shyr-Shea Chang, Tzung K. Hsiai, Van Savage, Yu-Hsiu Liu","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-14T06:06:02Z","title":"Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.04184","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:736d11ade052c7fe1bc4957a9ab0fcad14fbd17e16642c8460b23b9c87ae7678","target":"record","created_at":"2026-05-18T00:10:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2d7cdca0152e24855c27c5ba5f36749fd698fba3cb367afe7ec3b60b13a773af","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-14T06:06:02Z","title_canon_sha256":"f82c04862acc76583caa57404a3e2902af1d7bde58f83ee2ecb165d8abe1fe5c"},"schema_version":"1.0","source":{"id":"1512.04184","kind":"arxiv","version":3}},"canonical_sha256":"73c0a2ee0a47f31daa7ef03caa8fcbf482ec42bd1b3bffdbf01cd7cdbcff5e2a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"73c0a2ee0a47f31daa7ef03caa8fcbf482ec42bd1b3bffdbf01cd7cdbcff5e2a","first_computed_at":"2026-05-18T00:10:52.442055Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:10:52.442055Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"77C8FQbzs/+DgX0Z1PZ3OpwYBToid9vohtWejW+8vqq2AuZxc7+7MiUYzGcaieFii3ETIdb9hhdUjHwHT9dnBg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:10:52.442697Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.04184","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:736d11ade052c7fe1bc4957a9ab0fcad14fbd17e16642c8460b23b9c87ae7678","sha256:80e35381a3efed4db95fc3ca4fea09e6116f56fd2b5d871d01d2ef302544bf1e"],"state_sha256":"ccb9755eac6dc0de2c82ccd90c00548ec2b1526a233778f47b6d8972321f7dff"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"d3WERbDJ5Vm4TdXPHG+F5mhA5AOlMX2+2BWX4jPdLtZnFAGrtLTsji8wn/vkVA/GM1hC3+cU3od1rSz1th0QBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T12:15:45.992842Z","bundle_sha256":"419d7a2641767f10977dcf6ff8a4378e47d7f40e2ec808ff6c640fb1b7d38eea"}}