{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:OQPZBJDVL2AQ2S3URV6QH2G72Q","short_pith_number":"pith:OQPZBJDV","canonical_record":{"source":{"id":"1608.08793","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2016-08-31T10:02:09Z","cross_cats_sorted":[],"title_canon_sha256":"4f824061a13b2c0ae23685fe34b9d4e7d18b777221bb6de6ffaee01ed70e22a3","abstract_canon_sha256":"7116ef8189fbc88dfad6b12ea08f5cd75f4adf39d4a777874351977f6f77c052"},"schema_version":"1.0"},"canonical_sha256":"741f90a4755e810d4b748d7d03e8dfd427865c9b14f043d8ae6d45534e529e69","source":{"kind":"arxiv","id":"1608.08793","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1608.08793","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"arxiv_version","alias_value":"1608.08793v1","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1608.08793","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"pith_short_12","alias_value":"OQPZBJDVL2AQ","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_16","alias_value":"OQPZBJDVL2AQ2S3U","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_8","alias_value":"OQPZBJDV","created_at":"2026-05-18T12:30:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:OQPZBJDVL2AQ2S3URV6QH2G72Q","target":"record","payload":{"canonical_record":{"source":{"id":"1608.08793","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2016-08-31T10:02:09Z","cross_cats_sorted":[],"title_canon_sha256":"4f824061a13b2c0ae23685fe34b9d4e7d18b777221bb6de6ffaee01ed70e22a3","abstract_canon_sha256":"7116ef8189fbc88dfad6b12ea08f5cd75f4adf39d4a777874351977f6f77c052"},"schema_version":"1.0"},"canonical_sha256":"741f90a4755e810d4b748d7d03e8dfd427865c9b14f043d8ae6d45534e529e69","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:51:16.541567Z","signature_b64":"m8InbchrUdYBp+EafmGehhRDuDVk+7Z/65+dOjsFrRA3tXjgd14/oC2y6PZIM3qZhi7CaVD5mGq0YXDX9+GrAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"741f90a4755e810d4b748d7d03e8dfd427865c9b14f043d8ae6d45534e529e69","last_reissued_at":"2026-05-18T00:51:16.540976Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:51:16.540976Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1608.08793","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:51:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dqYnWPu49CzhAi+9Gc2fBSTBunG4eB6RjDsB5IJLikiTyUmwVqb1Wm0rqwmZ3UULa6y1LnmmeCll1fJUwlBiBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:43:49.912978Z"},"content_sha256":"c3f3ae35fb9884485023abea5a9a7388dc7cfbec932d89c715bf639faf63c19e","schema_version":"1.0","event_id":"sha256:c3f3ae35fb9884485023abea5a9a7388dc7cfbec932d89c715bf639faf63c19e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:OQPZBJDVL2AQ2S3URV6QH2G72Q","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The multilayer connectome of Caenorhabditis elegans","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Barry Bentley, Christopher L. Barnes, Edward T. Bullmore, Petra E. V\\'ertes, Robyn Branicky, William R. Schafer","submitted_at":"2016-08-31T10:02:09Z","abstract_excerpt":"Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function. Here we present a draft monoamine connectome, along with a partial neuropeptide connectome, for the nematode C. elegans, based on new and published expression data for biosynthetic genes and receptors. Thus, the neuronal connectome can be represented as a multiplex network, with synaptic, gap junction, and neuromodulatory layers representing alternative modes of inter"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1608.08793","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:51:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6Ik4SYhb1vJTMdGVOOIGBJ3+8YJ9ygZNXZ+Nh4taYadChOwPAeiZou0tPbODqUWw0CU7zGhytjznXbi/CijuDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:43:49.913339Z"},"content_sha256":"8b10d672d8f611dc93c19aac5faeb9ec83dc115b32e02075dde124be9971aec1","schema_version":"1.0","event_id":"sha256:8b10d672d8f611dc93c19aac5faeb9ec83dc115b32e02075dde124be9971aec1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/bundle.json","state_url":"https://pith.science/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T07:43:49Z","links":{"resolver":"https://pith.science/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q","bundle":"https://pith.science/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/bundle.json","state":"https://pith.science/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OQPZBJDVL2AQ2S3URV6QH2G72Q/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:OQPZBJDVL2AQ2S3URV6QH2G72Q","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7116ef8189fbc88dfad6b12ea08f5cd75f4adf39d4a777874351977f6f77c052","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2016-08-31T10:02:09Z","title_canon_sha256":"4f824061a13b2c0ae23685fe34b9d4e7d18b777221bb6de6ffaee01ed70e22a3"},"schema_version":"1.0","source":{"id":"1608.08793","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1608.08793","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"arxiv_version","alias_value":"1608.08793v1","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1608.08793","created_at":"2026-05-18T00:51:16Z"},{"alias_kind":"pith_short_12","alias_value":"OQPZBJDVL2AQ","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_16","alias_value":"OQPZBJDVL2AQ2S3U","created_at":"2026-05-18T12:30:36Z"},{"alias_kind":"pith_short_8","alias_value":"OQPZBJDV","created_at":"2026-05-18T12:30:36Z"}],"graph_snapshots":[{"event_id":"sha256:8b10d672d8f611dc93c19aac5faeb9ec83dc115b32e02075dde124be9971aec1","target":"graph","created_at":"2026-05-18T00:51:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is well established that extrasynaptic volume transmission, especially via monoamines and neuropeptides, is also critical to brain function. Here we present a draft monoamine connectome, along with a partial neuropeptide connectome, for the nematode C. elegans, based on new and published expression data for biosynthetic genes and receptors. Thus, the neuronal connectome can be represented as a multiplex network, with synaptic, gap junction, and neuromodulatory layers representing alternative modes of inter","authors_text":"Barry Bentley, Christopher L. Barnes, Edward T. Bullmore, Petra E. V\\'ertes, Robyn Branicky, William R. Schafer","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2016-08-31T10:02:09Z","title":"The multilayer connectome of Caenorhabditis elegans"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1608.08793","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c3f3ae35fb9884485023abea5a9a7388dc7cfbec932d89c715bf639faf63c19e","target":"record","created_at":"2026-05-18T00:51:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7116ef8189fbc88dfad6b12ea08f5cd75f4adf39d4a777874351977f6f77c052","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2016-08-31T10:02:09Z","title_canon_sha256":"4f824061a13b2c0ae23685fe34b9d4e7d18b777221bb6de6ffaee01ed70e22a3"},"schema_version":"1.0","source":{"id":"1608.08793","kind":"arxiv","version":1}},"canonical_sha256":"741f90a4755e810d4b748d7d03e8dfd427865c9b14f043d8ae6d45534e529e69","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"741f90a4755e810d4b748d7d03e8dfd427865c9b14f043d8ae6d45534e529e69","first_computed_at":"2026-05-18T00:51:16.540976Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:51:16.540976Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"m8InbchrUdYBp+EafmGehhRDuDVk+7Z/65+dOjsFrRA3tXjgd14/oC2y6PZIM3qZhi7CaVD5mGq0YXDX9+GrAg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:51:16.541567Z","signed_message":"canonical_sha256_bytes"},"source_id":"1608.08793","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c3f3ae35fb9884485023abea5a9a7388dc7cfbec932d89c715bf639faf63c19e","sha256:8b10d672d8f611dc93c19aac5faeb9ec83dc115b32e02075dde124be9971aec1"],"state_sha256":"e80ae1c490a2d7ce183dfba38180105ceb7e2d67fe697202bdd07417f2e3c6cc"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ulGxT5spodOriI+OA09T8xmgBYt66GNReOWZKfCZu17wgb0I/kUxeaVCRhLh4itHwX/0pSWC1N6VSWlMv04/Bw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T07:43:49.915419Z","bundle_sha256":"39ee7cc6ab307d977a9fdf9fd9c8da5d3222a299b7cedc618d5d0223f4e0d673"}}