{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:OTDH5J62HT7NDJG4BWPRNEDDVY","short_pith_number":"pith:OTDH5J62","canonical_record":{"source":{"id":"1009.3161","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-09-16T12:42:14Z","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"title_canon_sha256":"8ec5f3ed292a10020a68a2ad8f1d0f9537041c1eeb6f2023c4ec50887a0216fa","abstract_canon_sha256":"e3a40f6e0bc0304340cf25c2b8ff74b32c239dc07421900fdf5f61df5e53699e"},"schema_version":"1.0"},"canonical_sha256":"74c67ea7da3cfed1a4dc0d9f169063ae126151fed2cad71a220137f927d7bbce","source":{"kind":"arxiv","id":"1009.3161","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1009.3161","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"arxiv_version","alias_value":"1009.3161v1","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1009.3161","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"pith_short_12","alias_value":"OTDH5J62HT7N","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"OTDH5J62HT7NDJG4","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"OTDH5J62","created_at":"2026-05-18T12:26:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:OTDH5J62HT7NDJG4BWPRNEDDVY","target":"record","payload":{"canonical_record":{"source":{"id":"1009.3161","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-09-16T12:42:14Z","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"title_canon_sha256":"8ec5f3ed292a10020a68a2ad8f1d0f9537041c1eeb6f2023c4ec50887a0216fa","abstract_canon_sha256":"e3a40f6e0bc0304340cf25c2b8ff74b32c239dc07421900fdf5f61df5e53699e"},"schema_version":"1.0"},"canonical_sha256":"74c67ea7da3cfed1a4dc0d9f169063ae126151fed2cad71a220137f927d7bbce","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:40:46.872687Z","signature_b64":"bKk9R5l0Y/6NZHnd5axsjfga6KBP1NzlBqILRzZmKkrueIsnyzpS3xZqQJKbLWEtMinLdvMNC2Ts1l/QhhNLAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"74c67ea7da3cfed1a4dc0d9f169063ae126151fed2cad71a220137f927d7bbce","last_reissued_at":"2026-05-18T04:40:46.872095Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:40:46.872095Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1009.3161","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:40:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/pMEB6Pbbe0pPY7QwAazSxU4J8iYg6KEbVBrgQcAHEk2NXBVMcfb4EG5RcJZfu0FJvVV7SHzn7bqJmxuA18OAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T15:08:12.369374Z"},"content_sha256":"3b4c86a60d2372bde679c8f8b9b184d25e6a4c0f23e5a8cac0c43c8dc48951fd","schema_version":"1.0","event_id":"sha256:3b4c86a60d2372bde679c8f8b9b184d25e6a4c0f23e5a8cac0c43c8dc48951fd"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:OTDH5J62HT7NDJG4BWPRNEDDVY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"q-bio.BM","authors_text":"Barbara Windschiegl, Bert Nickel, Claudia Steinem, Georg Fritz, Kirstin Fritz","submitted_at":"2010-09-16T12:42:14Z","abstract_excerpt":"Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer. The tetramer is capable of bridging phospholipid membranes and it has been suggested to play a role in Ca2+-dependent exocytosis and cell-cell adhesion of metastatic cells. Here, we employ x-ray reflectivity measurements to resolve the conformation of Anx A2t upon Ca2+-dependent binding to single supported lipid bilayers (SLBs) composed of different mixtures of anionic (POPS) and neutral (POPC) phospholipids. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1009.3161","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:40:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"h8HhMRn1YjeAxIFRfnNUh8EQfNrumt7zThYRemzMj0P6Lz+sUNQVOHkdfIjciM9MPszSaqz4l15A0mxzC1ulCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T15:08:12.370024Z"},"content_sha256":"1d027185acc0a3f50159ebfe63935309ca8a0493e85d758401f22d950aa1f98b","schema_version":"1.0","event_id":"sha256:1d027185acc0a3f50159ebfe63935309ca8a0493e85d758401f22d950aa1f98b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/bundle.json","state_url":"https://pith.science/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T15:08:12Z","links":{"resolver":"https://pith.science/pith/OTDH5J62HT7NDJG4BWPRNEDDVY","bundle":"https://pith.science/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/bundle.json","state":"https://pith.science/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OTDH5J62HT7NDJG4BWPRNEDDVY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:OTDH5J62HT7NDJG4BWPRNEDDVY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e3a40f6e0bc0304340cf25c2b8ff74b32c239dc07421900fdf5f61df5e53699e","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-09-16T12:42:14Z","title_canon_sha256":"8ec5f3ed292a10020a68a2ad8f1d0f9537041c1eeb6f2023c4ec50887a0216fa"},"schema_version":"1.0","source":{"id":"1009.3161","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1009.3161","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"arxiv_version","alias_value":"1009.3161v1","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1009.3161","created_at":"2026-05-18T04:40:46Z"},{"alias_kind":"pith_short_12","alias_value":"OTDH5J62HT7N","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"OTDH5J62HT7NDJG4","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"OTDH5J62","created_at":"2026-05-18T12:26:12Z"}],"graph_snapshots":[{"event_id":"sha256:1d027185acc0a3f50159ebfe63935309ca8a0493e85d758401f22d950aa1f98b","target":"graph","created_at":"2026-05-18T04:40:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer. The tetramer is capable of bridging phospholipid membranes and it has been suggested to play a role in Ca2+-dependent exocytosis and cell-cell adhesion of metastatic cells. Here, we employ x-ray reflectivity measurements to resolve the conformation of Anx A2t upon Ca2+-dependent binding to single supported lipid bilayers (SLBs) composed of different mixtures of anionic (POPS) and neutral (POPC) phospholipids. ","authors_text":"Barbara Windschiegl, Bert Nickel, Claudia Steinem, Georg Fritz, Kirstin Fritz","cross_cats":["physics.bio-ph","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-09-16T12:42:14Z","title":"Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1009.3161","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3b4c86a60d2372bde679c8f8b9b184d25e6a4c0f23e5a8cac0c43c8dc48951fd","target":"record","created_at":"2026-05-18T04:40:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e3a40f6e0bc0304340cf25c2b8ff74b32c239dc07421900fdf5f61df5e53699e","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-09-16T12:42:14Z","title_canon_sha256":"8ec5f3ed292a10020a68a2ad8f1d0f9537041c1eeb6f2023c4ec50887a0216fa"},"schema_version":"1.0","source":{"id":"1009.3161","kind":"arxiv","version":1}},"canonical_sha256":"74c67ea7da3cfed1a4dc0d9f169063ae126151fed2cad71a220137f927d7bbce","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"74c67ea7da3cfed1a4dc0d9f169063ae126151fed2cad71a220137f927d7bbce","first_computed_at":"2026-05-18T04:40:46.872095Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:40:46.872095Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bKk9R5l0Y/6NZHnd5axsjfga6KBP1NzlBqILRzZmKkrueIsnyzpS3xZqQJKbLWEtMinLdvMNC2Ts1l/QhhNLAA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:40:46.872687Z","signed_message":"canonical_sha256_bytes"},"source_id":"1009.3161","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3b4c86a60d2372bde679c8f8b9b184d25e6a4c0f23e5a8cac0c43c8dc48951fd","sha256:1d027185acc0a3f50159ebfe63935309ca8a0493e85d758401f22d950aa1f98b"],"state_sha256":"658ac196fe2a31ff2f19e049ee5c31803ba6806497568994be404a73e9cf853a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QFy0mGXFHME8sYQf2sKXzCXu6sqwQdT/P4cE/YW9YA+dKXIBSw/NLaWgImatYfFdytEfPWgZZCLHk7RAMCJfCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T15:08:12.373831Z","bundle_sha256":"83373258faf285cf66d15130ae4f16c88c59cd7e3cdf267778ddf68543d8051e"}}