{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:OWP7M42VOUDK2PVPKXO3EA4LBL","short_pith_number":"pith:OWP7M42V","canonical_record":{"source":{"id":"1206.2070","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2012-03-06T14:22:32Z","cross_cats_sorted":[],"title_canon_sha256":"89e9b5ca2cd2b7ce8ab02a76b7908dcd55d82ee406f83283814181c1db38688a","abstract_canon_sha256":"20dab34cb8a9fe4232318ebe14f074e4bede9d52f139bd7eab92575bd8ec542a"},"schema_version":"1.0"},"canonical_sha256":"759ff673557506ad3eaf55ddb2038b0ac705ec70418f5895f2c11a20847559c5","source":{"kind":"arxiv","id":"1206.2070","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1206.2070","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"arxiv_version","alias_value":"1206.2070v1","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1206.2070","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"pith_short_12","alias_value":"OWP7M42VOUDK","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_16","alias_value":"OWP7M42VOUDK2PVP","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_8","alias_value":"OWP7M42V","created_at":"2026-05-18T12:27:16Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:OWP7M42VOUDK2PVPKXO3EA4LBL","target":"record","payload":{"canonical_record":{"source":{"id":"1206.2070","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2012-03-06T14:22:32Z","cross_cats_sorted":[],"title_canon_sha256":"89e9b5ca2cd2b7ce8ab02a76b7908dcd55d82ee406f83283814181c1db38688a","abstract_canon_sha256":"20dab34cb8a9fe4232318ebe14f074e4bede9d52f139bd7eab92575bd8ec542a"},"schema_version":"1.0"},"canonical_sha256":"759ff673557506ad3eaf55ddb2038b0ac705ec70418f5895f2c11a20847559c5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:53:53.543813Z","signature_b64":"IYroSsbBTSvWRJw3T6HLfrSU1Pepbcp0OylSfEdhHivhNEfMMBzDueE6OxtMonqRj0Qa0Rj1hm1ZT57NTWTzAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"759ff673557506ad3eaf55ddb2038b0ac705ec70418f5895f2c11a20847559c5","last_reissued_at":"2026-05-18T03:53:53.543298Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:53:53.543298Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1206.2070","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:53:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"W5mdLD8vCxZL9HcTkGu92qFLh3nQtF21QjBj8lHixrOkDFRJKzr4baCm8tNyUIQuHInSZ4us8vaMKsuNGlcZBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T01:29:15.848871Z"},"content_sha256":"67f3560ac71e38d44cdabc7e2e6548d4883fbc39fd613aeb94414c59893eb2f9","schema_version":"1.0","event_id":"sha256:67f3560ac71e38d44cdabc7e2e6548d4883fbc39fd613aeb94414c59893eb2f9"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:OWP7M42VOUDK2PVPKXO3EA4LBL","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Entromics -- thermodynamics of sequence dependent base incorporation into DNA reveals novel long-distance genome organization","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.OT","authors_text":"Jaroslav Nesetril, Petr Pancoska, Uday Kiran Para, Zdenek Moravek","submitted_at":"2012-03-06T14:22:32Z","abstract_excerpt":"Zero mode waveguide technology of next generation sequencing demonstrated sequence-dependence of the enzymatic reaction, incorporating a base into the genomic DNA. We show that these experimental results indicate existence of a previously uncharacterized physical property of DNA, the incorporation reaction chemical potential {\\Delta}{\\mu}. We use the combination of graph theory and statistical thermodynamics to derive entromics - a series of results providing the thermodynamic model of {\\Delta}{\\mu}. We also show that {\\Delta}{\\mu}i is quantitatively characterized as incorporation entropy. We "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1206.2070","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:53:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kzsdFXtqbn9huCxmUHEOUR4GZWuiHm7XSrXa4w6YtI+x1m5L6li4p4HQ8PKtOVfkzH3ikGrQfKYs1QpO+COqBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-23T01:29:15.849209Z"},"content_sha256":"8c5f539e734bc40f1c32ade8608c062e205674805dfc54990942f96fa1bfa4c8","schema_version":"1.0","event_id":"sha256:8c5f539e734bc40f1c32ade8608c062e205674805dfc54990942f96fa1bfa4c8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/bundle.json","state_url":"https://pith.science/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-23T01:29:15Z","links":{"resolver":"https://pith.science/pith/OWP7M42VOUDK2PVPKXO3EA4LBL","bundle":"https://pith.science/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/bundle.json","state":"https://pith.science/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OWP7M42VOUDK2PVPKXO3EA4LBL/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:OWP7M42VOUDK2PVPKXO3EA4LBL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"20dab34cb8a9fe4232318ebe14f074e4bede9d52f139bd7eab92575bd8ec542a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2012-03-06T14:22:32Z","title_canon_sha256":"89e9b5ca2cd2b7ce8ab02a76b7908dcd55d82ee406f83283814181c1db38688a"},"schema_version":"1.0","source":{"id":"1206.2070","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1206.2070","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"arxiv_version","alias_value":"1206.2070v1","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1206.2070","created_at":"2026-05-18T03:53:53Z"},{"alias_kind":"pith_short_12","alias_value":"OWP7M42VOUDK","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_16","alias_value":"OWP7M42VOUDK2PVP","created_at":"2026-05-18T12:27:16Z"},{"alias_kind":"pith_short_8","alias_value":"OWP7M42V","created_at":"2026-05-18T12:27:16Z"}],"graph_snapshots":[{"event_id":"sha256:8c5f539e734bc40f1c32ade8608c062e205674805dfc54990942f96fa1bfa4c8","target":"graph","created_at":"2026-05-18T03:53:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Zero mode waveguide technology of next generation sequencing demonstrated sequence-dependence of the enzymatic reaction, incorporating a base into the genomic DNA. We show that these experimental results indicate existence of a previously uncharacterized physical property of DNA, the incorporation reaction chemical potential {\\Delta}{\\mu}. We use the combination of graph theory and statistical thermodynamics to derive entromics - a series of results providing the thermodynamic model of {\\Delta}{\\mu}. We also show that {\\Delta}{\\mu}i is quantitatively characterized as incorporation entropy. We ","authors_text":"Jaroslav Nesetril, Petr Pancoska, Uday Kiran Para, Zdenek Moravek","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2012-03-06T14:22:32Z","title":"Entromics -- thermodynamics of sequence dependent base incorporation into DNA reveals novel long-distance genome organization"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1206.2070","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:67f3560ac71e38d44cdabc7e2e6548d4883fbc39fd613aeb94414c59893eb2f9","target":"record","created_at":"2026-05-18T03:53:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"20dab34cb8a9fe4232318ebe14f074e4bede9d52f139bd7eab92575bd8ec542a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2012-03-06T14:22:32Z","title_canon_sha256":"89e9b5ca2cd2b7ce8ab02a76b7908dcd55d82ee406f83283814181c1db38688a"},"schema_version":"1.0","source":{"id":"1206.2070","kind":"arxiv","version":1}},"canonical_sha256":"759ff673557506ad3eaf55ddb2038b0ac705ec70418f5895f2c11a20847559c5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"759ff673557506ad3eaf55ddb2038b0ac705ec70418f5895f2c11a20847559c5","first_computed_at":"2026-05-18T03:53:53.543298Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:53:53.543298Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"IYroSsbBTSvWRJw3T6HLfrSU1Pepbcp0OylSfEdhHivhNEfMMBzDueE6OxtMonqRj0Qa0Rj1hm1ZT57NTWTzAw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:53:53.543813Z","signed_message":"canonical_sha256_bytes"},"source_id":"1206.2070","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:67f3560ac71e38d44cdabc7e2e6548d4883fbc39fd613aeb94414c59893eb2f9","sha256:8c5f539e734bc40f1c32ade8608c062e205674805dfc54990942f96fa1bfa4c8"],"state_sha256":"8860ccb348ca989caf4ae5e3de99da607cb125d5cee449be6506854de5c45829"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uBEFw3vyOuXHcPrvMuybxmKDdHTQHyCHdaeNzrtp+EUZaa4Sg6FVjwa7i3TAkJnyst+jTHSFDRL2OQivh7nCDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-23T01:29:15.851152Z","bundle_sha256":"43a64c2399146dfa43710ced22fa015a54c0c0b3a322febaeb057d220e037084"}}