{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:OWSLEDU4MTRNGAMYTW2SGCYKGF","short_pith_number":"pith:OWSLEDU4","canonical_record":{"source":{"id":"2107.08931","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2021-07-19T14:44:39Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"05ec3c05b098e3c516c7e136ce47f184083894e12d729a927db6c31811ece92a","abstract_canon_sha256":"09afe59969e566aae4f169ca713157f8c9e0f6bba378ff76516e117fc112d2ca"},"schema_version":"1.0"},"canonical_sha256":"75a4b20e9c64e2d301989db5230b0a3160aefda4eff25a0348fe0f70982b5867","source":{"kind":"arxiv","id":"2107.08931","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.08931","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"arxiv_version","alias_value":"2107.08931v1","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.08931","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_12","alias_value":"OWSLEDU4MTRN","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_16","alias_value":"OWSLEDU4MTRNGAMY","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_8","alias_value":"OWSLEDU4","created_at":"2026-07-05T07:16:30Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:OWSLEDU4MTRNGAMYTW2SGCYKGF","target":"record","payload":{"canonical_record":{"source":{"id":"2107.08931","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2021-07-19T14:44:39Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"05ec3c05b098e3c516c7e136ce47f184083894e12d729a927db6c31811ece92a","abstract_canon_sha256":"09afe59969e566aae4f169ca713157f8c9e0f6bba378ff76516e117fc112d2ca"},"schema_version":"1.0"},"canonical_sha256":"75a4b20e9c64e2d301989db5230b0a3160aefda4eff25a0348fe0f70982b5867","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:16:30.384228Z","signature_b64":"bQdlD9TeAVp41OspJJKPbRu81ZApkRAj+kxVoGo37I9lQ3K9nD+3OWANtwQnvxcGZcQ/DCzBfJzutEzHS99fAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"75a4b20e9c64e2d301989db5230b0a3160aefda4eff25a0348fe0f70982b5867","last_reissued_at":"2026-07-05T07:16:30.383347Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:16:30.383347Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2107.08931","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:16:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+C2X3ffee2bajp54lEHzV+LQLz/4b9xgIX5anHazeL0+q3ArqnA+kbjo7EUfBYtN+qFq7k7rBYRjw0JmOv/bBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T22:39:56.954659Z"},"content_sha256":"bc21522b728d00b971a59e315ab33ded3e412cf3ebb72abf3adfb09902b31605","schema_version":"1.0","event_id":"sha256:bc21522b728d00b971a59e315ab33ded3e412cf3ebb72abf3adfb09902b31605"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:OWSLEDU4MTRNGAMYTW2SGCYKGF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Alessandro Rosa, Beatrice Silvestri, Edoardo Milanetti, Elsa Zacco, Federico Salaris, Giancarlo Ruocco, Gian Gaetano Tartaglia, Greta Grassmann, Lorenzo Di Rienzo, Mattia Miotto","submitted_at":"2021-07-19T14:44:39Z","abstract_excerpt":"Many of the molecular mechanisms underlying the pathological aggregation of proteins observed in neurodegenerative diseases are still not fully understood. Among the diseases associated with protein aggregates, for example, Amyotrophic Lateral Sclerosis (ALS) is of relevant importance. Although understanding the processes that cause the disease is still an open challenge, its relationship with protein aggregation is widely known. In particular, human TDP-43, an RNA/DNA binding protein, is a major component of pathological cytoplasmic inclusions described in ALS patients. The deposition of the "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.08931","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2107.08931/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:16:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"feW9OvISPRWpdE/veRKgkmeyyYt5VLWDWgQHlcQu/GCuquawcVKAJItMK7nfO8wIBDru8z4oB5VJqd5dwsEgCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T22:39:56.955311Z"},"content_sha256":"910407adb35cd4ef116dca96f6edf9e890def00223979d5ca401b4bf7e446b56","schema_version":"1.0","event_id":"sha256:910407adb35cd4ef116dca96f6edf9e890def00223979d5ca401b4bf7e446b56"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/bundle.json","state_url":"https://pith.science/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-22T22:39:56Z","links":{"resolver":"https://pith.science/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF","bundle":"https://pith.science/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/bundle.json","state":"https://pith.science/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OWSLEDU4MTRNGAMYTW2SGCYKGF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:OWSLEDU4MTRNGAMYTW2SGCYKGF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"09afe59969e566aae4f169ca713157f8c9e0f6bba378ff76516e117fc112d2ca","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2021-07-19T14:44:39Z","title_canon_sha256":"05ec3c05b098e3c516c7e136ce47f184083894e12d729a927db6c31811ece92a"},"schema_version":"1.0","source":{"id":"2107.08931","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2107.08931","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"arxiv_version","alias_value":"2107.08931v1","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2107.08931","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_12","alias_value":"OWSLEDU4MTRN","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_16","alias_value":"OWSLEDU4MTRNGAMY","created_at":"2026-07-05T07:16:30Z"},{"alias_kind":"pith_short_8","alias_value":"OWSLEDU4","created_at":"2026-07-05T07:16:30Z"}],"graph_snapshots":[{"event_id":"sha256:910407adb35cd4ef116dca96f6edf9e890def00223979d5ca401b4bf7e446b56","target":"graph","created_at":"2026-07-05T07:16:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2107.08931/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Many of the molecular mechanisms underlying the pathological aggregation of proteins observed in neurodegenerative diseases are still not fully understood. Among the diseases associated with protein aggregates, for example, Amyotrophic Lateral Sclerosis (ALS) is of relevant importance. Although understanding the processes that cause the disease is still an open challenge, its relationship with protein aggregation is widely known. In particular, human TDP-43, an RNA/DNA binding protein, is a major component of pathological cytoplasmic inclusions described in ALS patients. The deposition of the ","authors_text":"Alessandro Rosa, Beatrice Silvestri, Edoardo Milanetti, Elsa Zacco, Federico Salaris, Giancarlo Ruocco, Gian Gaetano Tartaglia, Greta Grassmann, Lorenzo Di Rienzo, Mattia Miotto","cross_cats":["q-bio.BM"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2021-07-19T14:44:39Z","title":"A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2107.08931","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bc21522b728d00b971a59e315ab33ded3e412cf3ebb72abf3adfb09902b31605","target":"record","created_at":"2026-07-05T07:16:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"09afe59969e566aae4f169ca713157f8c9e0f6bba378ff76516e117fc112d2ca","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2021-07-19T14:44:39Z","title_canon_sha256":"05ec3c05b098e3c516c7e136ce47f184083894e12d729a927db6c31811ece92a"},"schema_version":"1.0","source":{"id":"2107.08931","kind":"arxiv","version":1}},"canonical_sha256":"75a4b20e9c64e2d301989db5230b0a3160aefda4eff25a0348fe0f70982b5867","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"75a4b20e9c64e2d301989db5230b0a3160aefda4eff25a0348fe0f70982b5867","first_computed_at":"2026-07-05T07:16:30.383347Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:16:30.383347Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bQdlD9TeAVp41OspJJKPbRu81ZApkRAj+kxVoGo37I9lQ3K9nD+3OWANtwQnvxcGZcQ/DCzBfJzutEzHS99fAQ==","signature_status":"signed_v1","signed_at":"2026-07-05T07:16:30.384228Z","signed_message":"canonical_sha256_bytes"},"source_id":"2107.08931","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bc21522b728d00b971a59e315ab33ded3e412cf3ebb72abf3adfb09902b31605","sha256:910407adb35cd4ef116dca96f6edf9e890def00223979d5ca401b4bf7e446b56"],"state_sha256":"23f4ba43c97d3976b080f5f8941882e6395222a799291a82f889ac8737f62d6e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BPWd5zCMPYBVLno2HS+sB7khpRoqhtMUy8he24HRp4X+wxKWC13dcFpUH7elcdX9O6St0Nmmvns5U0mUGFv/Cg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-22T22:39:56.960259Z","bundle_sha256":"cf701efbc98ce27d5d0909e867e102594aab89ab1da9fc6c1ccafceb9f4710cf"}}