{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:OXD4A244XYBRUAKM2RTHALDWLK","short_pith_number":"pith:OXD4A244","canonical_record":{"source":{"id":"2308.15395","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2023-08-29T15:54:15Z","cross_cats_sorted":["q-bio.MN","q-bio.QM"],"title_canon_sha256":"02c4001f8afd948eeeccae00d96c14d008c51b85ebd3a3b218c45c7be6431dc7","abstract_canon_sha256":"3e87ffd238153fba1224ce2f9beb16c098d335aee1361d72ec0020dd810cd839"},"schema_version":"1.0"},"canonical_sha256":"75c7c06b9cbe031a014cd466702c765abdfcb46acd10200c115c20aa323253cb","source":{"kind":"arxiv","id":"2308.15395","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.15395","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"arxiv_version","alias_value":"2308.15395v2","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.15395","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_12","alias_value":"OXD4A244XYBR","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_16","alias_value":"OXD4A244XYBRUAKM","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_8","alias_value":"OXD4A244","created_at":"2026-07-05T11:05:20Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:OXD4A244XYBRUAKM2RTHALDWLK","target":"record","payload":{"canonical_record":{"source":{"id":"2308.15395","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2023-08-29T15:54:15Z","cross_cats_sorted":["q-bio.MN","q-bio.QM"],"title_canon_sha256":"02c4001f8afd948eeeccae00d96c14d008c51b85ebd3a3b218c45c7be6431dc7","abstract_canon_sha256":"3e87ffd238153fba1224ce2f9beb16c098d335aee1361d72ec0020dd810cd839"},"schema_version":"1.0"},"canonical_sha256":"75c7c06b9cbe031a014cd466702c765abdfcb46acd10200c115c20aa323253cb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:05:20.376026Z","signature_b64":"1KnWwRMrmqkU86EOM2cFNDVuEd6HPf47DZvDMghYTESFCEPX/cpybNzAqv22M5RDdYQWCuQeNyM4XatUX30JAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"75c7c06b9cbe031a014cd466702c765abdfcb46acd10200c115c20aa323253cb","last_reissued_at":"2026-07-05T11:05:20.375500Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:05:20.375500Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2308.15395","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:05:20Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"R8CNecWInTZZzVoYotAf2a6q5zqNRUiZziBIYayRxtfXsBTk0vDJDUUC74ErkpWWq8Ai9g/S2EQPwrzrS2G6Aw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T06:54:43.946639Z"},"content_sha256":"f658117727b59f8fa4bbb61189ee9b44f378ff01d6b47502ca893f86c46dde55","schema_version":"1.0","event_id":"sha256:f658117727b59f8fa4bbb61189ee9b44f378ff01d6b47502ca893f86c46dde55"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:OXD4A244XYBRUAKM2RTHALDWLK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The CausalBench challenge: A machine learning contest for gene network inference from single-cell perturbation data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN","q-bio.QM"],"primary_cat":"cs.LG","authors_text":"Achille Nazaret, Arash Mehrjou, Artemy Bakulin, Chris Wendler, Dariusz Brzezinski, Jacob Sackett-Sanders, Justin Hong, Kaiwen Deng, Marcin Kowiel, Markus P\\\"uschel, Mathieu Chevalley, Michael Ibrahim, Panagiotis Misiakos, Pascal Notin, Patrick Schwab, Wojciech Kotlowski, Yuanfang Guan, Yusuf Roohani","submitted_at":"2023-08-29T15:54:15Z","abstract_excerpt":"In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanisms underlying disease biology but also pivotal for formulating hypotheses about potential targets for new medicines. Recognizing the need to elevate the construction of these gene-gene interaction networks, especially from large-scale, real-world datasets of perturbed single cells, the CausalBench Challenge was initiated. This challenge aimed to inspire the machine learning community to enhance state-of-the-art method"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.15395","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2308.15395/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:05:20Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+aE/QQNXcPoeUfiVKOJL3XrbvTLGSlYSeTQEKgRUvY8FfvAR/mF7PMUe8HHC+oYzd17X0C4X3oDUjXLacomODA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T06:54:43.947020Z"},"content_sha256":"7ef0f2bcbf953f674d9063b839602e9d445d96a8378e0778781b6895ed87482c","schema_version":"1.0","event_id":"sha256:7ef0f2bcbf953f674d9063b839602e9d445d96a8378e0778781b6895ed87482c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/OXD4A244XYBRUAKM2RTHALDWLK/bundle.json","state_url":"https://pith.science/pith/OXD4A244XYBRUAKM2RTHALDWLK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/OXD4A244XYBRUAKM2RTHALDWLK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-07T06:54:43Z","links":{"resolver":"https://pith.science/pith/OXD4A244XYBRUAKM2RTHALDWLK","bundle":"https://pith.science/pith/OXD4A244XYBRUAKM2RTHALDWLK/bundle.json","state":"https://pith.science/pith/OXD4A244XYBRUAKM2RTHALDWLK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/OXD4A244XYBRUAKM2RTHALDWLK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:OXD4A244XYBRUAKM2RTHALDWLK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3e87ffd238153fba1224ce2f9beb16c098d335aee1361d72ec0020dd810cd839","cross_cats_sorted":["q-bio.MN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2023-08-29T15:54:15Z","title_canon_sha256":"02c4001f8afd948eeeccae00d96c14d008c51b85ebd3a3b218c45c7be6431dc7"},"schema_version":"1.0","source":{"id":"2308.15395","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.15395","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"arxiv_version","alias_value":"2308.15395v2","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.15395","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_12","alias_value":"OXD4A244XYBR","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_16","alias_value":"OXD4A244XYBRUAKM","created_at":"2026-07-05T11:05:20Z"},{"alias_kind":"pith_short_8","alias_value":"OXD4A244","created_at":"2026-07-05T11:05:20Z"}],"graph_snapshots":[{"event_id":"sha256:7ef0f2bcbf953f674d9063b839602e9d445d96a8378e0778781b6895ed87482c","target":"graph","created_at":"2026-07-05T11:05:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2308.15395/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"In drug discovery, mapping interactions between genes within cellular systems is a crucial early step. Such maps are not only foundational for understanding the molecular mechanisms underlying disease biology but also pivotal for formulating hypotheses about potential targets for new medicines. Recognizing the need to elevate the construction of these gene-gene interaction networks, especially from large-scale, real-world datasets of perturbed single cells, the CausalBench Challenge was initiated. This challenge aimed to inspire the machine learning community to enhance state-of-the-art method","authors_text":"Achille Nazaret, Arash Mehrjou, Artemy Bakulin, Chris Wendler, Dariusz Brzezinski, Jacob Sackett-Sanders, Justin Hong, Kaiwen Deng, Marcin Kowiel, Markus P\\\"uschel, Mathieu Chevalley, Michael Ibrahim, Panagiotis Misiakos, Pascal Notin, Patrick Schwab, Wojciech Kotlowski, Yuanfang Guan, Yusuf Roohani","cross_cats":["q-bio.MN","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2023-08-29T15:54:15Z","title":"The CausalBench challenge: A machine learning contest for gene network inference from single-cell perturbation data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.15395","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f658117727b59f8fa4bbb61189ee9b44f378ff01d6b47502ca893f86c46dde55","target":"record","created_at":"2026-07-05T11:05:20Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3e87ffd238153fba1224ce2f9beb16c098d335aee1361d72ec0020dd810cd839","cross_cats_sorted":["q-bio.MN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2023-08-29T15:54:15Z","title_canon_sha256":"02c4001f8afd948eeeccae00d96c14d008c51b85ebd3a3b218c45c7be6431dc7"},"schema_version":"1.0","source":{"id":"2308.15395","kind":"arxiv","version":2}},"canonical_sha256":"75c7c06b9cbe031a014cd466702c765abdfcb46acd10200c115c20aa323253cb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"75c7c06b9cbe031a014cd466702c765abdfcb46acd10200c115c20aa323253cb","first_computed_at":"2026-07-05T11:05:20.375500Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:05:20.375500Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"1KnWwRMrmqkU86EOM2cFNDVuEd6HPf47DZvDMghYTESFCEPX/cpybNzAqv22M5RDdYQWCuQeNyM4XatUX30JAQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:05:20.376026Z","signed_message":"canonical_sha256_bytes"},"source_id":"2308.15395","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f658117727b59f8fa4bbb61189ee9b44f378ff01d6b47502ca893f86c46dde55","sha256:7ef0f2bcbf953f674d9063b839602e9d445d96a8378e0778781b6895ed87482c"],"state_sha256":"57d7f1a556afb6b6fb1a132f70ff55bdeeb21d764e142e8bef643330b2f89016"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GyCs3T6OLriTlPuvrYuLSlurjrsqM7CiWwOyCdJAQ450pacxnniPVCrIX0ppw4WHX7Cl7GqGam/irqa+nqlODQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-07T06:54:43.949061Z","bundle_sha256":"6d2f516986eb64734307d96ab56dd6b5f26a1af23caa23f3acfc78788c93ea2f"}}