{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:OY6JDWBSONEGL3GWFF65T4CJQQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6ae14a11805e7ecc14bddffeeb140db651b9d96aa512b51b8432354bbd3c9d4b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-05-26T11:21:05Z","title_canon_sha256":"59069e80e1bc0feddfbbb6d548d678d9abc7dc8de5140415f02951c90ce715fb"},"schema_version":"1.0","source":{"id":"2405.16524","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2405.16524","created_at":"2026-07-05T08:23:31Z"},{"alias_kind":"arxiv_version","alias_value":"2405.16524v1","created_at":"2026-07-05T08:23:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2405.16524","created_at":"2026-07-05T08:23:31Z"},{"alias_kind":"pith_short_12","alias_value":"OY6JDWBSONEG","created_at":"2026-07-05T08:23:31Z"},{"alias_kind":"pith_short_16","alias_value":"OY6JDWBSONEGL3GW","created_at":"2026-07-05T08:23:31Z"},{"alias_kind":"pith_short_8","alias_value":"OY6JDWBS","created_at":"2026-07-05T08:23:31Z"}],"graph_snapshots":[{"event_id":"sha256:c9c9a71b8544f1a37e3c5358488d24ee1052d45b85a65eee30587cefac75f118","target":"graph","created_at":"2026-07-05T08:23:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2405.16524/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Estimating parameters of dynamic models from experimental data is a challenging, and often computationally-demanding task. It requires a large number of model simulations and objective function gradient computations, if gradient-based optimization is used. The gradient depends on derivatives of the state variables with respect to parameters, also called state sensitivities, which are expensive to compute. In many cases, steady-state computation is a part of model simulation, either due to steady-state data or an assumption that the system is at steady state at the initial time point. Various m","authors_text":"Daniel Weindl, Dilan Pathirana, Jan Hasenauer, Polina Lakrisenko","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-05-26T11:21:05Z","title":"Exploration of methods for computing sensitivities in ODE models at dynamic and steady states"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2405.16524","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:60132450cdf67dfdc678acfa9bdf2fdb64323066c98bf5f4e2b30cde55725319","target":"record","created_at":"2026-07-05T08:23:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6ae14a11805e7ecc14bddffeeb140db651b9d96aa512b51b8432354bbd3c9d4b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-05-26T11:21:05Z","title_canon_sha256":"59069e80e1bc0feddfbbb6d548d678d9abc7dc8de5140415f02951c90ce715fb"},"schema_version":"1.0","source":{"id":"2405.16524","kind":"arxiv","version":1}},"canonical_sha256":"763c91d832734865ecd6297dd9f049841eb0543192e7c3c70d04ebfb199d6512","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"763c91d832734865ecd6297dd9f049841eb0543192e7c3c70d04ebfb199d6512","first_computed_at":"2026-07-05T08:23:31.790553Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:23:31.790553Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"OKXIh4R80m9OSTz+pQTnLTnytL9ha+Dv8zz9zpCXYtcTPYTp5O8iv9nSyOmEhNdob8WxXiTUIHmEE9Im+CGxAw==","signature_status":"signed_v1","signed_at":"2026-07-05T08:23:31.791032Z","signed_message":"canonical_sha256_bytes"},"source_id":"2405.16524","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:60132450cdf67dfdc678acfa9bdf2fdb64323066c98bf5f4e2b30cde55725319","sha256:c9c9a71b8544f1a37e3c5358488d24ee1052d45b85a65eee30587cefac75f118"],"state_sha256":"7ead04dfe49ec7e15e9d9c0f3b304201e899e18eca183b2df6cf4cae94f4c3ee"}