{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:P2T6MKNFZNGXAOEFQAICFAQYWW","short_pith_number":"pith:P2T6MKNF","canonical_record":{"source":{"id":"1405.1569","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-05-07T11:01:07Z","cross_cats_sorted":[],"title_canon_sha256":"1b8a586daa5db8873075ced021a34b8b6a832bc0cb7e6d0e233306fbef1f0db4","abstract_canon_sha256":"245c6e368980f5b29843dc46207ad11ad9e859b493793a8dc5177b92affb2809"},"schema_version":"1.0"},"canonical_sha256":"7ea7e629a5cb4d7038858010228218b5a620fd6132736faa5864762ccf41b225","source":{"kind":"arxiv","id":"1405.1569","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1405.1569","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"arxiv_version","alias_value":"1405.1569v1","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1405.1569","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"pith_short_12","alias_value":"P2T6MKNFZNGX","created_at":"2026-05-18T12:28:43Z"},{"alias_kind":"pith_short_16","alias_value":"P2T6MKNFZNGXAOEF","created_at":"2026-05-18T12:28:43Z"},{"alias_kind":"pith_short_8","alias_value":"P2T6MKNF","created_at":"2026-05-18T12:28:43Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:P2T6MKNFZNGXAOEFQAICFAQYWW","target":"record","payload":{"canonical_record":{"source":{"id":"1405.1569","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-05-07T11:01:07Z","cross_cats_sorted":[],"title_canon_sha256":"1b8a586daa5db8873075ced021a34b8b6a832bc0cb7e6d0e233306fbef1f0db4","abstract_canon_sha256":"245c6e368980f5b29843dc46207ad11ad9e859b493793a8dc5177b92affb2809"},"schema_version":"1.0"},"canonical_sha256":"7ea7e629a5cb4d7038858010228218b5a620fd6132736faa5864762ccf41b225","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:52:24.453328Z","signature_b64":"aqyoFhHQXSKLUS1pvIhkMNw/U0WwcCJrUNPpM26X8rh/jDvO4m2k1OyisQ6jVZTr/+ReUite1h6Fq3lgrCpCAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7ea7e629a5cb4d7038858010228218b5a620fd6132736faa5864762ccf41b225","last_reissued_at":"2026-05-18T02:52:24.452587Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:52:24.452587Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1405.1569","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:52:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6N9mxEe6hlk+7m5LnWnfs2p4j5QKTyb7KUa1K+RXVoq9yafm21RqJ1phVqWLdbXtlJ1VIhmahUto3BcdfQ43BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T15:31:39.343821Z"},"content_sha256":"c77e9afdb633ea210da391e7c0ad1e04041ce7b2e384ba6bd0d77c8921e1e1e3","schema_version":"1.0","event_id":"sha256:c77e9afdb633ea210da391e7c0ad1e04041ce7b2e384ba6bd0d77c8921e1e1e3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:P2T6MKNFZNGXAOEFQAICFAQYWW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Adaptive Survival Trials","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Dominic Magirr, Franz Koenig, Martin Posch, Thomas Jaki","submitted_at":"2014-05-07T11:01:07Z","abstract_excerpt":"Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. It is therefore unfortunate that the important case of time-to-event endpoints is not easily handled by the standard theory. We analyze current methods that allow design modifications to be based on the full interim data, i.e., not only the observed event times but also secondary endpoint and safety data from patients who are yet to have an event. We show that the final test statistic may ignore a substantial subset "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1405.1569","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:52:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ecIezcgJmEf6tPoNP07PTmyhDKmXPX56uUsE9rtppMkNUmjpk2QtntESQtZUE8bz2YZeq1+7eh8kf4Fe4CrLAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T15:31:39.344159Z"},"content_sha256":"3f7a5ce8f8922ab3a5d9ccadd5728edce6b98e3ac22bf067f6eb506e4438e937","schema_version":"1.0","event_id":"sha256:3f7a5ce8f8922ab3a5d9ccadd5728edce6b98e3ac22bf067f6eb506e4438e937"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/bundle.json","state_url":"https://pith.science/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-26T15:31:39Z","links":{"resolver":"https://pith.science/pith/P2T6MKNFZNGXAOEFQAICFAQYWW","bundle":"https://pith.science/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/bundle.json","state":"https://pith.science/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/P2T6MKNFZNGXAOEFQAICFAQYWW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:P2T6MKNFZNGXAOEFQAICFAQYWW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"245c6e368980f5b29843dc46207ad11ad9e859b493793a8dc5177b92affb2809","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-05-07T11:01:07Z","title_canon_sha256":"1b8a586daa5db8873075ced021a34b8b6a832bc0cb7e6d0e233306fbef1f0db4"},"schema_version":"1.0","source":{"id":"1405.1569","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1405.1569","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"arxiv_version","alias_value":"1405.1569v1","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1405.1569","created_at":"2026-05-18T02:52:24Z"},{"alias_kind":"pith_short_12","alias_value":"P2T6MKNFZNGX","created_at":"2026-05-18T12:28:43Z"},{"alias_kind":"pith_short_16","alias_value":"P2T6MKNFZNGXAOEF","created_at":"2026-05-18T12:28:43Z"},{"alias_kind":"pith_short_8","alias_value":"P2T6MKNF","created_at":"2026-05-18T12:28:43Z"}],"graph_snapshots":[{"event_id":"sha256:3f7a5ce8f8922ab3a5d9ccadd5728edce6b98e3ac22bf067f6eb506e4438e937","target":"graph","created_at":"2026-05-18T02:52:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. It is therefore unfortunate that the important case of time-to-event endpoints is not easily handled by the standard theory. We analyze current methods that allow design modifications to be based on the full interim data, i.e., not only the observed event times but also secondary endpoint and safety data from patients who are yet to have an event. We show that the final test statistic may ignore a substantial subset ","authors_text":"Dominic Magirr, Franz Koenig, Martin Posch, Thomas Jaki","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-05-07T11:01:07Z","title":"Adaptive Survival Trials"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1405.1569","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c77e9afdb633ea210da391e7c0ad1e04041ce7b2e384ba6bd0d77c8921e1e1e3","target":"record","created_at":"2026-05-18T02:52:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"245c6e368980f5b29843dc46207ad11ad9e859b493793a8dc5177b92affb2809","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-05-07T11:01:07Z","title_canon_sha256":"1b8a586daa5db8873075ced021a34b8b6a832bc0cb7e6d0e233306fbef1f0db4"},"schema_version":"1.0","source":{"id":"1405.1569","kind":"arxiv","version":1}},"canonical_sha256":"7ea7e629a5cb4d7038858010228218b5a620fd6132736faa5864762ccf41b225","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7ea7e629a5cb4d7038858010228218b5a620fd6132736faa5864762ccf41b225","first_computed_at":"2026-05-18T02:52:24.452587Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:52:24.452587Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aqyoFhHQXSKLUS1pvIhkMNw/U0WwcCJrUNPpM26X8rh/jDvO4m2k1OyisQ6jVZTr/+ReUite1h6Fq3lgrCpCAA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:52:24.453328Z","signed_message":"canonical_sha256_bytes"},"source_id":"1405.1569","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c77e9afdb633ea210da391e7c0ad1e04041ce7b2e384ba6bd0d77c8921e1e1e3","sha256:3f7a5ce8f8922ab3a5d9ccadd5728edce6b98e3ac22bf067f6eb506e4438e937"],"state_sha256":"8b60ea10417568d47df880a6969a1dfc2814496f96c5282ab4afcefcebe95414"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+P2EnLoXRn2077Y9VCOFqBOOZGsx+RauU4bMx32gAH7uUqyG9dyFXMfBH4NvFhoEYdrv99eMNLyj/0OY/eYnCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-26T15:31:39.346085Z","bundle_sha256":"531568adbabb76972f1bdce3a4aae867d35e1660c99313cacd307cc09248065a"}}