{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:P3CSRPJSU67XWQCCKAQFOQIMBO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ee60883dc823f2148bc1f6144250d9701d15970f9df6d96c6c01a61b59d0a1a6","cross_cats_sorted":["cond-mat.stat-mech","nlin.AO","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-11-01T14:02:54Z","title_canon_sha256":"13013bd304c925b9c2ec87d707d8a2b54ad8a5699b91eac62e3dcbc2d7422dbc"},"schema_version":"1.0","source":{"id":"1011.0322","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.0322","created_at":"2026-05-18T04:28:19Z"},{"alias_kind":"arxiv_version","alias_value":"1011.0322v2","created_at":"2026-05-18T04:28:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.0322","created_at":"2026-05-18T04:28:19Z"},{"alias_kind":"pith_short_12","alias_value":"P3CSRPJSU67X","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"P3CSRPJSU67XWQCC","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"P3CSRPJS","created_at":"2026-05-18T12:26:12Z"}],"graph_snapshots":[{"event_id":"sha256:ad347cd7ad7f7ab1b55534ca607a50e1576eccfb47fefe3003386c297fc47eb2","target":"graph","created_at":"2026-05-18T04:28:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The mean fixation time of a deleterious mutant allele is studied beyond the diffusion approximation. As in Kimura's classical work [M. Kimura, Proc. Natl. Acad. Sci. U.S.A. Vol.77, 522 (1980)], that was motivated by the problem of fixation in the presence of amorphic or hypermorphic mutations, we consider a diallelic model at a single locus comprising a wild-type A and a mutant allele A' produced irreversibly from A at small uniform rate v. The relative fitnesses of the mutant homozygotes A'A', mutant heterozygotes A'A and wild-type homozygotes AA are 1-s, 1-h and 1, respectively, where it is ","authors_text":"Mauro Mobilia, Michael Assaf","cross_cats":["cond-mat.stat-mech","nlin.AO","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-11-01T14:02:54Z","title":"Fixation of a Deleterious Allele under Mutation Pressure and Finite Selection Intensity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.0322","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4b82ead9643f371095e40166c7136aeb1f112991313fcea4b697ea00a2b7f5fb","target":"record","created_at":"2026-05-18T04:28:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ee60883dc823f2148bc1f6144250d9701d15970f9df6d96c6c01a61b59d0a1a6","cross_cats_sorted":["cond-mat.stat-mech","nlin.AO","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-11-01T14:02:54Z","title_canon_sha256":"13013bd304c925b9c2ec87d707d8a2b54ad8a5699b91eac62e3dcbc2d7422dbc"},"schema_version":"1.0","source":{"id":"1011.0322","kind":"arxiv","version":2}},"canonical_sha256":"7ec528bd32a7bf7b4042502057410c0b8c23d07e7e5ee461a16dc7a1be522ab4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7ec528bd32a7bf7b4042502057410c0b8c23d07e7e5ee461a16dc7a1be522ab4","first_computed_at":"2026-05-18T04:28:19.932921Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:28:19.932921Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nXcRmZY1hs2L85xx6QSnJHEeiI2nV8KmonIpVP4/nSQ2qJfG0zZ1rmwg/VvoA+MmdnAu8cmzEffDp8An5fZSAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T04:28:19.933437Z","signed_message":"canonical_sha256_bytes"},"source_id":"1011.0322","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4b82ead9643f371095e40166c7136aeb1f112991313fcea4b697ea00a2b7f5fb","sha256:ad347cd7ad7f7ab1b55534ca607a50e1576eccfb47fefe3003386c297fc47eb2"],"state_sha256":"1914d8dac1ee5b075f46b012e164c51fe27c46522e1b48d1797f988360c2c154"}