{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:P4MSZVPFHFSXVBE5UD66NH4ZSH","short_pith_number":"pith:P4MSZVPF","canonical_record":{"source":{"id":"1812.04533","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:47:33Z","cross_cats_sorted":["q-bio.NC"],"title_canon_sha256":"4c2001b4dd2878329a97bc3cc2f88b4749f131d9a94c83b117950a2a2fc79660","abstract_canon_sha256":"920c769326b449d54e174fcf0002dfb53ef0d92dc6f9249c6824932f76075803"},"schema_version":"1.0"},"canonical_sha256":"7f192cd5e539657a849da0fde69f9991d508d3a381a878570650093dfc4b2e7c","source":{"kind":"arxiv","id":"1812.04533","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.04533","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"arxiv_version","alias_value":"1812.04533v1","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.04533","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"pith_short_12","alias_value":"P4MSZVPFHFSX","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_16","alias_value":"P4MSZVPFHFSXVBE5","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_8","alias_value":"P4MSZVPF","created_at":"2026-05-18T12:32:43Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:P4MSZVPFHFSXVBE5UD66NH4ZSH","target":"record","payload":{"canonical_record":{"source":{"id":"1812.04533","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:47:33Z","cross_cats_sorted":["q-bio.NC"],"title_canon_sha256":"4c2001b4dd2878329a97bc3cc2f88b4749f131d9a94c83b117950a2a2fc79660","abstract_canon_sha256":"920c769326b449d54e174fcf0002dfb53ef0d92dc6f9249c6824932f76075803"},"schema_version":"1.0"},"canonical_sha256":"7f192cd5e539657a849da0fde69f9991d508d3a381a878570650093dfc4b2e7c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:58:31.781096Z","signature_b64":"jULdLxofBJIjGhW8GMvk0nld6pY7DWZ5S/KogjqXzaONfLnwsq38od3qtlA1LSkHK6XqL/t2Ekf3c+reaNWKCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7f192cd5e539657a849da0fde69f9991d508d3a381a878570650093dfc4b2e7c","last_reissued_at":"2026-05-17T23:58:31.780581Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:58:31.780581Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1812.04533","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"R4gqabLH8yMh8fsJOPEpkHie2DZQ5AyQSsxqJh8Qdvuaed3u30BWo1NeiOPLuNSg5++boDEbjRccQ6rP5BhADw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T14:56:51.016068Z"},"content_sha256":"77f51416650cb8ba2a05f7a2e80a09b02886439cc1e395d37086cbb938fd4085","schema_version":"1.0","event_id":"sha256:77f51416650cb8ba2a05f7a2e80a09b02886439cc1e395d37086cbb938fd4085"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:P4MSZVPFHFSXVBE5UD66NH4ZSH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Localization of Epileptic Seizure Focus by Computerized Analysis of fMRI Recordings","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.NC"],"primary_cat":"q-bio.QM","authors_text":"Michael J. Paldino, Rasoul Hekmati, Robert Azencott, Wei Zhang, Zili D. Chu","submitted_at":"2018-12-11T16:47:33Z","abstract_excerpt":"By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with significant inter-connectivity provide efficient inputs for our Multi-Layer Perceptron (MLP) classifier. By imposing rigorous parameter parsimony to avoid over fitting we constr"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.04533","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:58:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/hAETAdfIDcmURDKYv1Otf60csDdxaXsVDWn72FWntuqnhOS7RpaIrw/dlccf2JPW3oOCT2Qcb9SPRARiUyYBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T14:56:51.016436Z"},"content_sha256":"83ddad68fa1b2e78c38b17796ff7e6348f2a5a418d161d59e9a5a43169d6e590","schema_version":"1.0","event_id":"sha256:83ddad68fa1b2e78c38b17796ff7e6348f2a5a418d161d59e9a5a43169d6e590"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/bundle.json","state_url":"https://pith.science/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T14:56:51Z","links":{"resolver":"https://pith.science/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH","bundle":"https://pith.science/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/bundle.json","state":"https://pith.science/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/P4MSZVPFHFSXVBE5UD66NH4ZSH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:P4MSZVPFHFSXVBE5UD66NH4ZSH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"920c769326b449d54e174fcf0002dfb53ef0d92dc6f9249c6824932f76075803","cross_cats_sorted":["q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:47:33Z","title_canon_sha256":"4c2001b4dd2878329a97bc3cc2f88b4749f131d9a94c83b117950a2a2fc79660"},"schema_version":"1.0","source":{"id":"1812.04533","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.04533","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"arxiv_version","alias_value":"1812.04533v1","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.04533","created_at":"2026-05-17T23:58:31Z"},{"alias_kind":"pith_short_12","alias_value":"P4MSZVPFHFSX","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_16","alias_value":"P4MSZVPFHFSXVBE5","created_at":"2026-05-18T12:32:43Z"},{"alias_kind":"pith_short_8","alias_value":"P4MSZVPF","created_at":"2026-05-18T12:32:43Z"}],"graph_snapshots":[{"event_id":"sha256:83ddad68fa1b2e78c38b17796ff7e6348f2a5a418d161d59e9a5a43169d6e590","target":"graph","created_at":"2026-05-17T23:58:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"By computerized analysis of cortical activity recorded via fMRI for pediatric epilepsy patients, we implement algorithmic localization of epileptic seizure focus within one of eight cortical lobes. Our innovative machine learning techniques involve intensive analysis of large matrices of mutual information coefficients between pairs of anatomically identified cortical regions. Drastic selection of pairs of regions with significant inter-connectivity provide efficient inputs for our Multi-Layer Perceptron (MLP) classifier. By imposing rigorous parameter parsimony to avoid over fitting we constr","authors_text":"Michael J. Paldino, Rasoul Hekmati, Robert Azencott, Wei Zhang, Zili D. Chu","cross_cats":["q-bio.NC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:47:33Z","title":"Localization of Epileptic Seizure Focus by Computerized Analysis of fMRI Recordings"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.04533","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:77f51416650cb8ba2a05f7a2e80a09b02886439cc1e395d37086cbb938fd4085","target":"record","created_at":"2026-05-17T23:58:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"920c769326b449d54e174fcf0002dfb53ef0d92dc6f9249c6824932f76075803","cross_cats_sorted":["q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2018-12-11T16:47:33Z","title_canon_sha256":"4c2001b4dd2878329a97bc3cc2f88b4749f131d9a94c83b117950a2a2fc79660"},"schema_version":"1.0","source":{"id":"1812.04533","kind":"arxiv","version":1}},"canonical_sha256":"7f192cd5e539657a849da0fde69f9991d508d3a381a878570650093dfc4b2e7c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7f192cd5e539657a849da0fde69f9991d508d3a381a878570650093dfc4b2e7c","first_computed_at":"2026-05-17T23:58:31.780581Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:58:31.780581Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"jULdLxofBJIjGhW8GMvk0nld6pY7DWZ5S/KogjqXzaONfLnwsq38od3qtlA1LSkHK6XqL/t2Ekf3c+reaNWKCw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:58:31.781096Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.04533","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:77f51416650cb8ba2a05f7a2e80a09b02886439cc1e395d37086cbb938fd4085","sha256:83ddad68fa1b2e78c38b17796ff7e6348f2a5a418d161d59e9a5a43169d6e590"],"state_sha256":"3f5269c73dc9581e5425d278c4349d66bcb692b18de6f2000a91d050e97481e5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WhaAGjcrZn0h9uJ59EVpFmeLY+NOQjm2Eg+iGKjUTXR1HXeSyptPjK094pETF0qNnjzLlqLPMo1uqBCOL286Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T14:56:51.018521Z","bundle_sha256":"ff79817bf255acf9e076a4ca6f4d20b4a23364a99502bdd8e26bf2b658f0516f"}}