{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:PKTP2HTUEKPFXYFD3OJYOWEJ3E","short_pith_number":"pith:PKTP2HTU","canonical_record":{"source":{"id":"1908.00618","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2019-08-01T20:45:56Z","cross_cats_sorted":[],"title_canon_sha256":"e58c7c37024b77fe765c8e2b927893836cb6feb97ab4583429baa15df3e0f1a7","abstract_canon_sha256":"9866893b8fd96b49db9df89216db5d4e680f1c7bd9fc58df42dac885d129835f"},"schema_version":"1.0"},"canonical_sha256":"7aa6fd1e74229e5be0a3db93875889d929c2f684562ee09078c035b3f3b5967e","source":{"kind":"arxiv","id":"1908.00618","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.00618","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"arxiv_version","alias_value":"1908.00618v1","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.00618","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_12","alias_value":"PKTP2HTUEKPF","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_16","alias_value":"PKTP2HTUEKPFXYFD","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_8","alias_value":"PKTP2HTU","created_at":"2026-07-04T23:51:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:PKTP2HTUEKPFXYFD3OJYOWEJ3E","target":"record","payload":{"canonical_record":{"source":{"id":"1908.00618","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2019-08-01T20:45:56Z","cross_cats_sorted":[],"title_canon_sha256":"e58c7c37024b77fe765c8e2b927893836cb6feb97ab4583429baa15df3e0f1a7","abstract_canon_sha256":"9866893b8fd96b49db9df89216db5d4e680f1c7bd9fc58df42dac885d129835f"},"schema_version":"1.0"},"canonical_sha256":"7aa6fd1e74229e5be0a3db93875889d929c2f684562ee09078c035b3f3b5967e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-04T23:51:07.367417Z","signature_b64":"lMM4/3GjuGXlSe135+9OD5HsmUi2hTF4VKcDbNSIzy8SehXvYHK0wsEZVAh5A2wKIS4onv1dl+Lv2a33srNsCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7aa6fd1e74229e5be0a3db93875889d929c2f684562ee09078c035b3f3b5967e","last_reissued_at":"2026-07-04T23:51:07.366846Z","signature_status":"signed_v1","first_computed_at":"2026-07-04T23:51:07.366846Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1908.00618","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:51:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IfpesKXQDMzST7KRYCc0TsBjANsZGoqeBEU9eEXwUpqWKrieWA6IbUxk+sS0DLFR/umkfgF/ENUDRxl8CzgsAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T05:24:22.492859Z"},"content_sha256":"31f9a07d8ec02dbd2361646f365bfa859c8a6b78cdd42987b8294e4ab1ebf231","schema_version":"1.0","event_id":"sha256:31f9a07d8ec02dbd2361646f365bfa859c8a6b78cdd42987b8294e4ab1ebf231"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:PKTP2HTUEKPFXYFD3OJYOWEJ3E","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Analyzing Basket Trials under Multisource Exchangeability Assumptions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.CO","authors_text":"Alexander M. Kaizer, Brian P. Hobbs, H. Amy Xia, Michael J. Kane, Nan Chen, Xun Jiang","submitted_at":"2019-08-01T20:45:56Z","abstract_excerpt":"Basket designs are prospective clinical trials that are devised with the hypothesis that the presence of selected molecular features determine a patient's subsequent response to a particular \"targeted\" treatment strategy. Basket trials are designed to enroll multiple clinical subpopulations to which it is assumed that the therapy in question offers beneficial efficacy in the presence of the targeted molecular profile. The treatment, however, may not offer acceptable efficacy to all subpopulations enrolled. Moreover, for rare disease settings, such as oncology wherein these trials have become p"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.00618","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.00618/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:51:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"k8RNbxWuPtiXD0YBWZvUn/r4/5KNMEtCJaqg0P8V/FwAVEheGto6u4Df423HQ7L6Vr+pMbzscPH03ZmIp9utAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T05:24:22.493247Z"},"content_sha256":"f5f53a24042b40322e67e029c7ed60cb576dd8e0c6277719e72a3c058cf72e5e","schema_version":"1.0","event_id":"sha256:f5f53a24042b40322e67e029c7ed60cb576dd8e0c6277719e72a3c058cf72e5e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/bundle.json","state_url":"https://pith.science/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-07T05:24:22Z","links":{"resolver":"https://pith.science/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E","bundle":"https://pith.science/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/bundle.json","state":"https://pith.science/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/state.json","well_known_bundle":"https://pith.science/.well-known/pith/PKTP2HTUEKPFXYFD3OJYOWEJ3E/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:PKTP2HTUEKPFXYFD3OJYOWEJ3E","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9866893b8fd96b49db9df89216db5d4e680f1c7bd9fc58df42dac885d129835f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2019-08-01T20:45:56Z","title_canon_sha256":"e58c7c37024b77fe765c8e2b927893836cb6feb97ab4583429baa15df3e0f1a7"},"schema_version":"1.0","source":{"id":"1908.00618","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.00618","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"arxiv_version","alias_value":"1908.00618v1","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.00618","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_12","alias_value":"PKTP2HTUEKPF","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_16","alias_value":"PKTP2HTUEKPFXYFD","created_at":"2026-07-04T23:51:07Z"},{"alias_kind":"pith_short_8","alias_value":"PKTP2HTU","created_at":"2026-07-04T23:51:07Z"}],"graph_snapshots":[{"event_id":"sha256:f5f53a24042b40322e67e029c7ed60cb576dd8e0c6277719e72a3c058cf72e5e","target":"graph","created_at":"2026-07-04T23:51:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1908.00618/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Basket designs are prospective clinical trials that are devised with the hypothesis that the presence of selected molecular features determine a patient's subsequent response to a particular \"targeted\" treatment strategy. Basket trials are designed to enroll multiple clinical subpopulations to which it is assumed that the therapy in question offers beneficial efficacy in the presence of the targeted molecular profile. The treatment, however, may not offer acceptable efficacy to all subpopulations enrolled. Moreover, for rare disease settings, such as oncology wherein these trials have become p","authors_text":"Alexander M. Kaizer, Brian P. Hobbs, H. Amy Xia, Michael J. Kane, Nan Chen, Xun Jiang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2019-08-01T20:45:56Z","title":"Analyzing Basket Trials under Multisource Exchangeability Assumptions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.00618","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:31f9a07d8ec02dbd2361646f365bfa859c8a6b78cdd42987b8294e4ab1ebf231","target":"record","created_at":"2026-07-04T23:51:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9866893b8fd96b49db9df89216db5d4e680f1c7bd9fc58df42dac885d129835f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.CO","submitted_at":"2019-08-01T20:45:56Z","title_canon_sha256":"e58c7c37024b77fe765c8e2b927893836cb6feb97ab4583429baa15df3e0f1a7"},"schema_version":"1.0","source":{"id":"1908.00618","kind":"arxiv","version":1}},"canonical_sha256":"7aa6fd1e74229e5be0a3db93875889d929c2f684562ee09078c035b3f3b5967e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7aa6fd1e74229e5be0a3db93875889d929c2f684562ee09078c035b3f3b5967e","first_computed_at":"2026-07-04T23:51:07.366846Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-04T23:51:07.366846Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lMM4/3GjuGXlSe135+9OD5HsmUi2hTF4VKcDbNSIzy8SehXvYHK0wsEZVAh5A2wKIS4onv1dl+Lv2a33srNsCQ==","signature_status":"signed_v1","signed_at":"2026-07-04T23:51:07.367417Z","signed_message":"canonical_sha256_bytes"},"source_id":"1908.00618","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:31f9a07d8ec02dbd2361646f365bfa859c8a6b78cdd42987b8294e4ab1ebf231","sha256:f5f53a24042b40322e67e029c7ed60cb576dd8e0c6277719e72a3c058cf72e5e"],"state_sha256":"114aacb01e033eec4a443075bb78431e63827822802aeda3dd97fe9c34383454"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wqc788BRI47Uw/y34XpdNlpc7fkK6lTdd73oqxhAddXO3FXaNZtumSEIrGOc9Yn9BiPOVcYRdY2F9JCQD+sVBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-07T05:24:22.495735Z","bundle_sha256":"adbb4137e9f435cfbe9f7d4fc5cc7b2dc11cd6618b2e6a8d5a6594467ed276ef"}}