{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:PL7ZAJQ76ZNNMRTSOM6S562SJM","short_pith_number":"pith:PL7ZAJQ7","canonical_record":{"source":{"id":"1105.0900","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2011-05-04T19:11:38Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"345d2e326279577d5ebace42ecedf0776f23982daf68e4afe099669d6d8e1cd8","abstract_canon_sha256":"263efe5bf1130f76a0263f97210cdac792af757138b98a6a40089d71446bf7e7"},"schema_version":"1.0"},"canonical_sha256":"7aff90261ff65ad64672733d2efb524b347b0cc4912e3521dcc485e626607f54","source":{"kind":"arxiv","id":"1105.0900","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.0900","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"arxiv_version","alias_value":"1105.0900v1","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.0900","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"pith_short_12","alias_value":"PL7ZAJQ76ZNN","created_at":"2026-05-18T12:26:39Z"},{"alias_kind":"pith_short_16","alias_value":"PL7ZAJQ76ZNNMRTS","created_at":"2026-05-18T12:26:39Z"},{"alias_kind":"pith_short_8","alias_value":"PL7ZAJQ7","created_at":"2026-05-18T12:26:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:PL7ZAJQ76ZNNMRTSOM6S562SJM","target":"record","payload":{"canonical_record":{"source":{"id":"1105.0900","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2011-05-04T19:11:38Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"345d2e326279577d5ebace42ecedf0776f23982daf68e4afe099669d6d8e1cd8","abstract_canon_sha256":"263efe5bf1130f76a0263f97210cdac792af757138b98a6a40089d71446bf7e7"},"schema_version":"1.0"},"canonical_sha256":"7aff90261ff65ad64672733d2efb524b347b0cc4912e3521dcc485e626607f54","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:23:01.578552Z","signature_b64":"QAw7P3gdyz7q7UL2wj3GlFL91Tbd9TFtOZBEh39UB1cCvE2RlujweG7HFa2YLwPdZ1v5NN2o2ywlh45H/rS5AA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7aff90261ff65ad64672733d2efb524b347b0cc4912e3521dcc485e626607f54","last_reissued_at":"2026-05-18T04:23:01.578038Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:23:01.578038Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1105.0900","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:23:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lAxyycLAzzTGtAu83UP2d+O58t0fr3T1scAYmhdzwcCO7v/2q0bknnRRcEbvcnEpF5OqZLx0+y9Lu0Dw0SO/Cw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T01:54:06.595466Z"},"content_sha256":"86ff2e5d697ad757b484c47e47233a5547af006ca42bdd22e86e4e8e651e7669","schema_version":"1.0","event_id":"sha256:86ff2e5d697ad757b484c47e47233a5547af006ca42bdd22e86e4e8e651e7669"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:PL7ZAJQ76ZNNMRTSOM6S562SJM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Removing System Noise from Comparative Genomic Hybridization Data by Self-Self Analysis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.QM","authors_text":"Anthony Leotta, B. Lakshmi, Boris Yamrom, Dan Levy, Diane Esposito, Jude Kendall, Kenny Ye, Michael Ronemus, Michael Wigler, Vladimir Grubor, Yoon-ha Lee","submitted_at":"2011-05-04T19:11:38Z","abstract_excerpt":"Genomic copy number variation (CNV) is a large source of variation between organisms, and its consequences include phenotypic differences and genetic disorders. CNVs are commonly detected by hybridizing genomic DNA to microarrays of nucleic acid probes. System noise caused by operational and probe performance variability complicates the interpretation of these data. To minimize the distortion of genetic signal by system noise, we have explored the latter in an archive of hybridizations in which no genetic signal is expected. This archive is obtained by comparative genomic hybridization (CGH) o"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.0900","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:23:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"duiANUSd6ojAia3tTIsgajOKYr7vaDNczfDXh9bBm2fmtmSf05Zj9lV1VtYll+3byg0hn3+GbIeoTMJPM0qFDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T01:54:06.596116Z"},"content_sha256":"8263804b7304fa3a295a5f6070ed9c9970e54d1c1229c4e2764119336e3ce159","schema_version":"1.0","event_id":"sha256:8263804b7304fa3a295a5f6070ed9c9970e54d1c1229c4e2764119336e3ce159"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/bundle.json","state_url":"https://pith.science/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T01:54:06Z","links":{"resolver":"https://pith.science/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM","bundle":"https://pith.science/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/bundle.json","state":"https://pith.science/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/PL7ZAJQ76ZNNMRTSOM6S562SJM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:PL7ZAJQ76ZNNMRTSOM6S562SJM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"263efe5bf1130f76a0263f97210cdac792af757138b98a6a40089d71446bf7e7","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2011-05-04T19:11:38Z","title_canon_sha256":"345d2e326279577d5ebace42ecedf0776f23982daf68e4afe099669d6d8e1cd8"},"schema_version":"1.0","source":{"id":"1105.0900","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1105.0900","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"arxiv_version","alias_value":"1105.0900v1","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1105.0900","created_at":"2026-05-18T04:23:01Z"},{"alias_kind":"pith_short_12","alias_value":"PL7ZAJQ76ZNN","created_at":"2026-05-18T12:26:39Z"},{"alias_kind":"pith_short_16","alias_value":"PL7ZAJQ76ZNNMRTS","created_at":"2026-05-18T12:26:39Z"},{"alias_kind":"pith_short_8","alias_value":"PL7ZAJQ7","created_at":"2026-05-18T12:26:39Z"}],"graph_snapshots":[{"event_id":"sha256:8263804b7304fa3a295a5f6070ed9c9970e54d1c1229c4e2764119336e3ce159","target":"graph","created_at":"2026-05-18T04:23:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genomic copy number variation (CNV) is a large source of variation between organisms, and its consequences include phenotypic differences and genetic disorders. CNVs are commonly detected by hybridizing genomic DNA to microarrays of nucleic acid probes. System noise caused by operational and probe performance variability complicates the interpretation of these data. To minimize the distortion of genetic signal by system noise, we have explored the latter in an archive of hybridizations in which no genetic signal is expected. This archive is obtained by comparative genomic hybridization (CGH) o","authors_text":"Anthony Leotta, B. Lakshmi, Boris Yamrom, Dan Levy, Diane Esposito, Jude Kendall, Kenny Ye, Michael Ronemus, Michael Wigler, Vladimir Grubor, Yoon-ha Lee","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2011-05-04T19:11:38Z","title":"Removing System Noise from Comparative Genomic Hybridization Data by Self-Self Analysis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1105.0900","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:86ff2e5d697ad757b484c47e47233a5547af006ca42bdd22e86e4e8e651e7669","target":"record","created_at":"2026-05-18T04:23:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"263efe5bf1130f76a0263f97210cdac792af757138b98a6a40089d71446bf7e7","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2011-05-04T19:11:38Z","title_canon_sha256":"345d2e326279577d5ebace42ecedf0776f23982daf68e4afe099669d6d8e1cd8"},"schema_version":"1.0","source":{"id":"1105.0900","kind":"arxiv","version":1}},"canonical_sha256":"7aff90261ff65ad64672733d2efb524b347b0cc4912e3521dcc485e626607f54","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7aff90261ff65ad64672733d2efb524b347b0cc4912e3521dcc485e626607f54","first_computed_at":"2026-05-18T04:23:01.578038Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:23:01.578038Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"QAw7P3gdyz7q7UL2wj3GlFL91Tbd9TFtOZBEh39UB1cCvE2RlujweG7HFa2YLwPdZ1v5NN2o2ywlh45H/rS5AA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:23:01.578552Z","signed_message":"canonical_sha256_bytes"},"source_id":"1105.0900","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:86ff2e5d697ad757b484c47e47233a5547af006ca42bdd22e86e4e8e651e7669","sha256:8263804b7304fa3a295a5f6070ed9c9970e54d1c1229c4e2764119336e3ce159"],"state_sha256":"aa8f305d1c61a43ca47aeddff38e475b3ad0dce44ebee39252ed3595fb457a0c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oEIv1F1zrrnAajTmFnDKeYKc8AUcJkMwK7sEP03JPlcfX/Jkz5xNJYUnXsGHZMW5okQO7+aRWSdfRwUIA5qNAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T01:54:06.599661Z","bundle_sha256":"dca5340339d2e7658184da03fe64dc76ad8c51a25ef32722391e4f6959b2d85a"}}