{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:POD34MNQFAWPPGSN4GG65KMEWS","short_pith_number":"pith:POD34MNQ","schema_version":"1.0","canonical_sha256":"7b87be31b0282cf79a4de18deea984b4a82259d9ad1cd328e19f62806b415f6e","source":{"kind":"arxiv","id":"1611.00666","version":2},"attestation_state":"computed","paper":{"title":"On the role of extrinsic noise in microRNA-mediated bimodal gene expression","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Carla Bosia, Marco Del Giudice, Silvia Grigolon, Stefano Bo","submitted_at":"2016-11-02T16:18:53Z","abstract_excerpt":"Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Experimental evidences of phenotypic differentiation are given by the presence of bimodal distributions of gene expression levels, where the modes of the distribution often correspond to different physiological states of the system. We theoretically address the presence of bimodal phenotypes in the context of microRNA (miRNA)-mediated regulation. MiRNAs are small noncoding RNA molecules that downregulate the expression of their target mRNAs. The nature of this"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1611.00666","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-11-02T16:18:53Z","cross_cats_sorted":[],"title_canon_sha256":"3964d6ae3312d8261fbab9b7118c2d9c036b9971b7392fb52698d9a89802b651","abstract_canon_sha256":"374f06433229e670b92d468501debbb696b97908d27c3661ed6f5075159aeaf3"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:46:13.982106Z","signature_b64":"O13EH8/nJ4P7QqNns+iJIocsZVobMmBcqJ5Ta6P2YTm3Xqo8o0+XvImaEj0Wpe7bKddOy8eUntt2aL2NasXXCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7b87be31b0282cf79a4de18deea984b4a82259d9ad1cd328e19f62806b415f6e","last_reissued_at":"2026-05-18T00:46:13.981493Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:46:13.981493Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"On the role of extrinsic noise in microRNA-mediated bimodal gene expression","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Carla Bosia, Marco Del Giudice, Silvia Grigolon, Stefano Bo","submitted_at":"2016-11-02T16:18:53Z","abstract_excerpt":"Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Experimental evidences of phenotypic differentiation are given by the presence of bimodal distributions of gene expression levels, where the modes of the distribution often correspond to different physiological states of the system. We theoretically address the presence of bimodal phenotypes in the context of microRNA (miRNA)-mediated regulation. MiRNAs are small noncoding RNA molecules that downregulate the expression of their target mRNAs. The nature of this"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1611.00666","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1611.00666","created_at":"2026-05-18T00:46:13.981589+00:00"},{"alias_kind":"arxiv_version","alias_value":"1611.00666v2","created_at":"2026-05-18T00:46:13.981589+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1611.00666","created_at":"2026-05-18T00:46:13.981589+00:00"},{"alias_kind":"pith_short_12","alias_value":"POD34MNQFAWP","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_16","alias_value":"POD34MNQFAWPPGSN","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_8","alias_value":"POD34MNQ","created_at":"2026-05-18T12:30:39.010887+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS","json":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS.json","graph_json":"https://pith.science/api/pith-number/POD34MNQFAWPPGSN4GG65KMEWS/graph.json","events_json":"https://pith.science/api/pith-number/POD34MNQFAWPPGSN4GG65KMEWS/events.json","paper":"https://pith.science/paper/POD34MNQ"},"agent_actions":{"view_html":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS","download_json":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS.json","view_paper":"https://pith.science/paper/POD34MNQ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1611.00666&json=true","fetch_graph":"https://pith.science/api/pith-number/POD34MNQFAWPPGSN4GG65KMEWS/graph.json","fetch_events":"https://pith.science/api/pith-number/POD34MNQFAWPPGSN4GG65KMEWS/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS/action/timestamp_anchor","attest_storage":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS/action/storage_attestation","attest_author":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS/action/author_attestation","sign_citation":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS/action/citation_signature","submit_replication":"https://pith.science/pith/POD34MNQFAWPPGSN4GG65KMEWS/action/replication_record"}},"created_at":"2026-05-18T00:46:13.981589+00:00","updated_at":"2026-05-18T00:46:13.981589+00:00"}