{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:PQVZTJROK26WVGY475WGUN245S","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d0c2bf76d4168e28932fbcf45b379030ae5ece317440008813b731c1f0401f68","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2023-01-30T15:49:24Z","title_canon_sha256":"a79032a6b1a19f517df43b271c06f1797042aea3de95bb9dd9639d14a0c2da45"},"schema_version":"1.0","source":{"id":"2301.13010","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2301.13010","created_at":"2026-07-05T05:36:59Z"},{"alias_kind":"arxiv_version","alias_value":"2301.13010v1","created_at":"2026-07-05T05:36:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2301.13010","created_at":"2026-07-05T05:36:59Z"},{"alias_kind":"pith_short_12","alias_value":"PQVZTJROK26W","created_at":"2026-07-05T05:36:59Z"},{"alias_kind":"pith_short_16","alias_value":"PQVZTJROK26WVGY4","created_at":"2026-07-05T05:36:59Z"},{"alias_kind":"pith_short_8","alias_value":"PQVZTJRO","created_at":"2026-07-05T05:36:59Z"}],"graph_snapshots":[{"event_id":"sha256:e57b98eb3659f29b23011b9a4d987cf670b29c2e5cf9caa130e941e7e67515d8","target":"graph","created_at":"2026-07-05T05:36:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2301.13010/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cross-links are considered to be a key component of collagen fibrils as they can change the fibrillar behavior in various ways. Advanced-Glycation Endproducts (AGEs), one particular type of cross-links, have been shown to accumulate and impair the mechanical properties of collageneous tissues, whereas enzymatic cross-links (ECLs) are known for stabilizing the structure of the fibril. However, the reasons for whether a given type of cross-link improves or impairs the material properties remain unknown. Here, we use coarse-grained steered molecular models to evaluate the effect of AGEs and ECLs ","authors_text":"Chun-Yu Ke, Claire Acevedo, David Kammer, Julia Kamml","cross_cats":["q-bio.BM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2023-01-30T15:49:24Z","title":"The influence of AGEs and enzymatic cross-links on the mechanical properties of collagen fibrils"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2301.13010","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6ca16a2b65c906fc127d8a535dc3442beb7a19df2be55cfa0abe00666f5341e4","target":"record","created_at":"2026-07-05T05:36:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d0c2bf76d4168e28932fbcf45b379030ae5ece317440008813b731c1f0401f68","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2023-01-30T15:49:24Z","title_canon_sha256":"a79032a6b1a19f517df43b271c06f1797042aea3de95bb9dd9639d14a0c2da45"},"schema_version":"1.0","source":{"id":"2301.13010","kind":"arxiv","version":1}},"canonical_sha256":"7c2b99a62e56bd6a9b1cff6c6a375cec9e4efd3cce229aed4adc57e05b68e99b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7c2b99a62e56bd6a9b1cff6c6a375cec9e4efd3cce229aed4adc57e05b68e99b","first_computed_at":"2026-07-05T05:36:59.977411Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T05:36:59.977411Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Wl4x1cSzVwHlqKtEoEeoPVtjr94U8W+RAy5LgDPAYnL83S50Gn2N/vHFBgmQp/85ET1je/iF3ad6ObRnOMdTBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T05:36:59.978027Z","signed_message":"canonical_sha256_bytes"},"source_id":"2301.13010","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6ca16a2b65c906fc127d8a535dc3442beb7a19df2be55cfa0abe00666f5341e4","sha256:e57b98eb3659f29b23011b9a4d987cf670b29c2e5cf9caa130e941e7e67515d8"],"state_sha256":"dc713c6092366cfd4d58fc82ae841615a27553b8beea72f09fa6d93cdb1e3d9d"}