{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:PS3PILJQIN6PL6HZTK6DEA2PKD","short_pith_number":"pith:PS3PILJQ","canonical_record":{"source":{"id":"1512.01616","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-12-05T03:41:00Z","cross_cats_sorted":["q-bio.GN","stat.ME"],"title_canon_sha256":"75bc98126e66f82b94c03bc037a55c2aadbb6d54989a9ac821eae563add6c44b","abstract_canon_sha256":"a75aa8c494a8e1b1544d521c0a25b9232b274e6eeea823ceced8554bd6fbf3cc"},"schema_version":"1.0"},"canonical_sha256":"7cb6f42d30437cf5f8f99abc32034f50fa84925414b113fb9998fe8014569f1a","source":{"kind":"arxiv","id":"1512.01616","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.01616","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"arxiv_version","alias_value":"1512.01616v1","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.01616","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"pith_short_12","alias_value":"PS3PILJQIN6P","created_at":"2026-05-18T12:29:37Z"},{"alias_kind":"pith_short_16","alias_value":"PS3PILJQIN6PL6HZ","created_at":"2026-05-18T12:29:37Z"},{"alias_kind":"pith_short_8","alias_value":"PS3PILJQ","created_at":"2026-05-18T12:29:37Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:PS3PILJQIN6PL6HZTK6DEA2PKD","target":"record","payload":{"canonical_record":{"source":{"id":"1512.01616","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-12-05T03:41:00Z","cross_cats_sorted":["q-bio.GN","stat.ME"],"title_canon_sha256":"75bc98126e66f82b94c03bc037a55c2aadbb6d54989a9ac821eae563add6c44b","abstract_canon_sha256":"a75aa8c494a8e1b1544d521c0a25b9232b274e6eeea823ceced8554bd6fbf3cc"},"schema_version":"1.0"},"canonical_sha256":"7cb6f42d30437cf5f8f99abc32034f50fa84925414b113fb9998fe8014569f1a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:25:10.812309Z","signature_b64":"g91ozFnIx013zeNV1AxWY15Dnh2dCh7b8jNtCyf628R8kVyiAxmRNQw2fpMXD0rI3C/RTXEDq+W35UQTGthBAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7cb6f42d30437cf5f8f99abc32034f50fa84925414b113fb9998fe8014569f1a","last_reissued_at":"2026-05-18T01:25:10.811679Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:25:10.811679Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.01616","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:25:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"423UxNVz+4iqzb1ZxDm9zsqNIsMh5ST88UpF/qFU7jq2jcWmburf7L/JlECEvyNOkEejAnBiX7rX9GTvO+fJDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:34:26.222125Z"},"content_sha256":"b07e86383bc7df930e7602770349bf4edcf3520d40e4393a2447c91270198a9a","schema_version":"1.0","event_id":"sha256:b07e86383bc7df930e7602770349bf4edcf3520d40e4393a2447c91270198a9a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:PS3PILJQIN6PL6HZTK6DEA2PKD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Bayesian test to identify variance effects","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN","stat.ME"],"primary_cat":"q-bio.QM","authors_text":"Barbara E Engelhardt, Bianca Dumitrascu, Gregory Darnell, Julien Ayroles","submitted_at":"2015-12-05T03:41:00Z","abstract_excerpt":"Identifying genetic variants that regulate quantitative traits, or QTLs, is the primary focus of the field of statistical genetics. Most current methods are limited to identifying mean effects, or associations between genotype and the mean value of a quantitative trait. It is possible, however, that a genetic variant may affect the variance of the quantitative trait in lieu of, or in addition to, affecting the trait mean. Here, we develop a general methodological approach to identifying covariates with variance effects on a quantitative trait using a Bayesian heteroskedastic linear regression "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.01616","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:25:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lVbGIj1SjtCbX2bCCOHxQOSL3KC9uwt2DyyWeYRqJYsxE1qb9TJ8hwVHA7fCoHB2/ENowFikj+s648LkaOWVCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T07:34:26.222803Z"},"content_sha256":"d972a2541e042ca098372bcbc4c8fda1b432bdc05d99e909b4b073bf80b1f576","schema_version":"1.0","event_id":"sha256:d972a2541e042ca098372bcbc4c8fda1b432bdc05d99e909b4b073bf80b1f576"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/bundle.json","state_url":"https://pith.science/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T07:34:26Z","links":{"resolver":"https://pith.science/pith/PS3PILJQIN6PL6HZTK6DEA2PKD","bundle":"https://pith.science/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/bundle.json","state":"https://pith.science/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/PS3PILJQIN6PL6HZTK6DEA2PKD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:PS3PILJQIN6PL6HZTK6DEA2PKD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a75aa8c494a8e1b1544d521c0a25b9232b274e6eeea823ceced8554bd6fbf3cc","cross_cats_sorted":["q-bio.GN","stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-12-05T03:41:00Z","title_canon_sha256":"75bc98126e66f82b94c03bc037a55c2aadbb6d54989a9ac821eae563add6c44b"},"schema_version":"1.0","source":{"id":"1512.01616","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.01616","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"arxiv_version","alias_value":"1512.01616v1","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.01616","created_at":"2026-05-18T01:25:10Z"},{"alias_kind":"pith_short_12","alias_value":"PS3PILJQIN6P","created_at":"2026-05-18T12:29:37Z"},{"alias_kind":"pith_short_16","alias_value":"PS3PILJQIN6PL6HZ","created_at":"2026-05-18T12:29:37Z"},{"alias_kind":"pith_short_8","alias_value":"PS3PILJQ","created_at":"2026-05-18T12:29:37Z"}],"graph_snapshots":[{"event_id":"sha256:d972a2541e042ca098372bcbc4c8fda1b432bdc05d99e909b4b073bf80b1f576","target":"graph","created_at":"2026-05-18T01:25:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Identifying genetic variants that regulate quantitative traits, or QTLs, is the primary focus of the field of statistical genetics. Most current methods are limited to identifying mean effects, or associations between genotype and the mean value of a quantitative trait. It is possible, however, that a genetic variant may affect the variance of the quantitative trait in lieu of, or in addition to, affecting the trait mean. Here, we develop a general methodological approach to identifying covariates with variance effects on a quantitative trait using a Bayesian heteroskedastic linear regression ","authors_text":"Barbara E Engelhardt, Bianca Dumitrascu, Gregory Darnell, Julien Ayroles","cross_cats":["q-bio.GN","stat.ME"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-12-05T03:41:00Z","title":"A Bayesian test to identify variance effects"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.01616","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b07e86383bc7df930e7602770349bf4edcf3520d40e4393a2447c91270198a9a","target":"record","created_at":"2026-05-18T01:25:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a75aa8c494a8e1b1544d521c0a25b9232b274e6eeea823ceced8554bd6fbf3cc","cross_cats_sorted":["q-bio.GN","stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-12-05T03:41:00Z","title_canon_sha256":"75bc98126e66f82b94c03bc037a55c2aadbb6d54989a9ac821eae563add6c44b"},"schema_version":"1.0","source":{"id":"1512.01616","kind":"arxiv","version":1}},"canonical_sha256":"7cb6f42d30437cf5f8f99abc32034f50fa84925414b113fb9998fe8014569f1a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7cb6f42d30437cf5f8f99abc32034f50fa84925414b113fb9998fe8014569f1a","first_computed_at":"2026-05-18T01:25:10.811679Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:25:10.811679Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"g91ozFnIx013zeNV1AxWY15Dnh2dCh7b8jNtCyf628R8kVyiAxmRNQw2fpMXD0rI3C/RTXEDq+W35UQTGthBAw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:25:10.812309Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.01616","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b07e86383bc7df930e7602770349bf4edcf3520d40e4393a2447c91270198a9a","sha256:d972a2541e042ca098372bcbc4c8fda1b432bdc05d99e909b4b073bf80b1f576"],"state_sha256":"674e7759fa9a2158aaf6ace739652d151e51ab468d13cd1e7e52600aeca0bee0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"je4TXLZ1KeMFLiwG6YS/2m8GaDkIwYVhz/YtUijL54qIEYrefMmAmisqKXR++iQytY9x9zVGs+D4hWrGYhuRDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T07:34:26.226372Z","bundle_sha256":"59d1cdb3ff453d4d5d017d277b77a9c4337fec463dac3aec66c43d0a3030a238"}}