{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:PXNXGJS4NB2TMGHDG3C65CP6IJ","short_pith_number":"pith:PXNXGJS4","canonical_record":{"source":{"id":"1006.0727","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-06-03T19:56:45Z","cross_cats_sorted":[],"title_canon_sha256":"46ad1fccf6c7397c8af0d89ab5a815dbb35d2b1b9c1ce5a889253796633c17c3","abstract_canon_sha256":"a90acc987677a98d7c8189ef4d3e86e00437fc6de42aabc71e1f1b1ecc1a4bc0"},"schema_version":"1.0"},"canonical_sha256":"7ddb73265c68753618e336c5ee89fe42546cfc6adb6f20f8a863cf944417e86d","source":{"kind":"arxiv","id":"1006.0727","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1006.0727","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"arxiv_version","alias_value":"1006.0727v2","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1006.0727","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"pith_short_12","alias_value":"PXNXGJS4NB2T","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"PXNXGJS4NB2TMGHD","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"PXNXGJS4","created_at":"2026-05-18T12:26:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:PXNXGJS4NB2TMGHDG3C65CP6IJ","target":"record","payload":{"canonical_record":{"source":{"id":"1006.0727","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-06-03T19:56:45Z","cross_cats_sorted":[],"title_canon_sha256":"46ad1fccf6c7397c8af0d89ab5a815dbb35d2b1b9c1ce5a889253796633c17c3","abstract_canon_sha256":"a90acc987677a98d7c8189ef4d3e86e00437fc6de42aabc71e1f1b1ecc1a4bc0"},"schema_version":"1.0"},"canonical_sha256":"7ddb73265c68753618e336c5ee89fe42546cfc6adb6f20f8a863cf944417e86d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:05:15.181368Z","signature_b64":"sxyIWopazYNcQNfAPvQEI2FGVQgbQ/HA2x50ZebROBuxQYDqQJkJki6t1OejGIUzUFFcOGZqf0gFxOIWn4cgDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"7ddb73265c68753618e336c5ee89fe42546cfc6adb6f20f8a863cf944417e86d","last_reissued_at":"2026-05-18T04:05:15.180674Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:05:15.180674Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1006.0727","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:05:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/3CtKamkwfL+/ib1YCG12v6IDyKjDXWhYdMc8rC+zPgS5txPrCY0wTllHZdXbdrTTpMlkeplgz+6BMC3HdGyBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-23T21:28:40.429424Z"},"content_sha256":"88504bb8baf9012a6cfb75751a7f21ce62c3b9b77af5e73aace2f85947bc9b67","schema_version":"1.0","event_id":"sha256:88504bb8baf9012a6cfb75751a7f21ce62c3b9b77af5e73aace2f85947bc9b67"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:PXNXGJS4NB2TMGHDG3C65CP6IJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Biological control networks suggest the use of biomimetic sets for combinatorial therapies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Andrew D. McCulloch, Carlo Piermarocchi, Giovanni Paternostro, Jacob D. Feala, Jorge Cortes, Phillip M. Duxbury","submitted_at":"2010-06-03T19:56:45Z","abstract_excerpt":"Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these \"many-to-many\" combinatorial control systems are poorly understood. Here we analyze distinct cellular networks (transcription factors, microRNAs, and protein kinases) and a drug-target network. Certain network properties seem universal across systems and species, suggesting the existence of common control strategies in biology. The number of controllers is ~8% of targets and the density of links is 2.5% \\pm 1.2%. Links per node are predominantly exponentially distributed, imp"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1006.0727","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:05:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Oy0nL7AQ6CUtEf2EWmPyt5UNFgaGkIopB+Ag0iB8uax1AsSaDNCw5IbSXkWaebVdQLhiYB+wP86U8G9vvY6KDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-23T21:28:40.430089Z"},"content_sha256":"414607d69e6f84592fafa792c0f21b308a8880efba11ed83e2e56eeecb872ae8","schema_version":"1.0","event_id":"sha256:414607d69e6f84592fafa792c0f21b308a8880efba11ed83e2e56eeecb872ae8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/bundle.json","state_url":"https://pith.science/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-23T21:28:40Z","links":{"resolver":"https://pith.science/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ","bundle":"https://pith.science/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/bundle.json","state":"https://pith.science/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/PXNXGJS4NB2TMGHDG3C65CP6IJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:PXNXGJS4NB2TMGHDG3C65CP6IJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a90acc987677a98d7c8189ef4d3e86e00437fc6de42aabc71e1f1b1ecc1a4bc0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-06-03T19:56:45Z","title_canon_sha256":"46ad1fccf6c7397c8af0d89ab5a815dbb35d2b1b9c1ce5a889253796633c17c3"},"schema_version":"1.0","source":{"id":"1006.0727","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1006.0727","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"arxiv_version","alias_value":"1006.0727v2","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1006.0727","created_at":"2026-05-18T04:05:15Z"},{"alias_kind":"pith_short_12","alias_value":"PXNXGJS4NB2T","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"PXNXGJS4NB2TMGHD","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"PXNXGJS4","created_at":"2026-05-18T12:26:12Z"}],"graph_snapshots":[{"event_id":"sha256:414607d69e6f84592fafa792c0f21b308a8880efba11ed83e2e56eeecb872ae8","target":"graph","created_at":"2026-05-18T04:05:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cells are regulated by networks of controllers having many targets, and targets affected by many controllers, but these \"many-to-many\" combinatorial control systems are poorly understood. Here we analyze distinct cellular networks (transcription factors, microRNAs, and protein kinases) and a drug-target network. Certain network properties seem universal across systems and species, suggesting the existence of common control strategies in biology. The number of controllers is ~8% of targets and the density of links is 2.5% \\pm 1.2%. Links per node are predominantly exponentially distributed, imp","authors_text":"Andrew D. McCulloch, Carlo Piermarocchi, Giovanni Paternostro, Jacob D. Feala, Jorge Cortes, Phillip M. Duxbury","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-06-03T19:56:45Z","title":"Biological control networks suggest the use of biomimetic sets for combinatorial therapies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1006.0727","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:88504bb8baf9012a6cfb75751a7f21ce62c3b9b77af5e73aace2f85947bc9b67","target":"record","created_at":"2026-05-18T04:05:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a90acc987677a98d7c8189ef4d3e86e00437fc6de42aabc71e1f1b1ecc1a4bc0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-06-03T19:56:45Z","title_canon_sha256":"46ad1fccf6c7397c8af0d89ab5a815dbb35d2b1b9c1ce5a889253796633c17c3"},"schema_version":"1.0","source":{"id":"1006.0727","kind":"arxiv","version":2}},"canonical_sha256":"7ddb73265c68753618e336c5ee89fe42546cfc6adb6f20f8a863cf944417e86d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"7ddb73265c68753618e336c5ee89fe42546cfc6adb6f20f8a863cf944417e86d","first_computed_at":"2026-05-18T04:05:15.180674Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:05:15.180674Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"sxyIWopazYNcQNfAPvQEI2FGVQgbQ/HA2x50ZebROBuxQYDqQJkJki6t1OejGIUzUFFcOGZqf0gFxOIWn4cgDw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:05:15.181368Z","signed_message":"canonical_sha256_bytes"},"source_id":"1006.0727","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:88504bb8baf9012a6cfb75751a7f21ce62c3b9b77af5e73aace2f85947bc9b67","sha256:414607d69e6f84592fafa792c0f21b308a8880efba11ed83e2e56eeecb872ae8"],"state_sha256":"b091ed9886b33d8bf66e24182005190e69b99618136ea151417e61fb92926fb2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WVflo9XLsTRbX6zwZXFoep8xJ8Zvo9Gl4THI5yOw8SBGVsS7exIaJedTR0Dd2cZEwugdMB5UsO2S4oNSW0rABg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-23T21:28:40.433889Z","bundle_sha256":"3ac54af4d7d957ca638f6f5a2e33562310eb63beb810a98038b9e8f8af43b178"}}