{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:Q4LWSQN5M3VRT2FOZME4JDSEXF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b07dbfa671f0dafa40a5d852343a4d6a19e746eace094f68a4f0ac14a399da87","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-07-10T05:36:17Z","title_canon_sha256":"03747a51835b7681bc8455e91863a94fd5ffe8ed20531b43b22a3f4f09c3b099"},"schema_version":"1.0","source":{"id":"1907.04516","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1907.04516","created_at":"2026-05-17T23:40:59Z"},{"alias_kind":"arxiv_version","alias_value":"1907.04516v1","created_at":"2026-05-17T23:40:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1907.04516","created_at":"2026-05-17T23:40:59Z"},{"alias_kind":"pith_short_12","alias_value":"Q4LWSQN5M3VR","created_at":"2026-05-18T12:33:24Z"},{"alias_kind":"pith_short_16","alias_value":"Q4LWSQN5M3VRT2FO","created_at":"2026-05-18T12:33:24Z"},{"alias_kind":"pith_short_8","alias_value":"Q4LWSQN5","created_at":"2026-05-18T12:33:24Z"}],"graph_snapshots":[{"event_id":"sha256:926776464704f463826046c8770a3912f35a9454e867639e8315f12b2b7fe96d","target":"graph","created_at":"2026-05-17T23:40:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In this article, we derive the limit of detection for a two-step molecular recognition process and show that in-spite of all the recognition reactions being in equilibrium the overall error rates can be reduced exactly as much as possible in non-equilibrium methods such as kinetic proofreading.","authors_text":"Manoj M Varma, Tuhin Chakrabortty","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-07-10T05:36:17Z","title":"Error reduction in biosensors using secondary labeling"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1907.04516","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b98e2f6af7c19b4cd3535565c9d4713c607393418564f12db16d04cec3d673e9","target":"record","created_at":"2026-05-17T23:40:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b07dbfa671f0dafa40a5d852343a4d6a19e746eace094f68a4f0ac14a399da87","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-07-10T05:36:17Z","title_canon_sha256":"03747a51835b7681bc8455e91863a94fd5ffe8ed20531b43b22a3f4f09c3b099"},"schema_version":"1.0","source":{"id":"1907.04516","kind":"arxiv","version":1}},"canonical_sha256":"87176941bd66eb19e8aecb09c48e44b97b5f5b02db8cf44cbe07de5d6323cb48","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"87176941bd66eb19e8aecb09c48e44b97b5f5b02db8cf44cbe07de5d6323cb48","first_computed_at":"2026-05-17T23:40:59.996992Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:40:59.996992Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/0I9esuRTG8pGMXlmUzu10oIrriyvafN+maWl0ph609E8vkgGSaQnLOkHH+74QYvPXfIZ2+oO0y5Q/RbjzFWDA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:40:59.997525Z","signed_message":"canonical_sha256_bytes"},"source_id":"1907.04516","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b98e2f6af7c19b4cd3535565c9d4713c607393418564f12db16d04cec3d673e9","sha256:926776464704f463826046c8770a3912f35a9454e867639e8315f12b2b7fe96d"],"state_sha256":"90c4c648609e7b9c38e74aafb75bfe28405f85664db5f4e0352c5f4e786cd4bb"}