{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:QDC5PVWH6U23R6CJ33MHUWDVVY","short_pith_number":"pith:QDC5PVWH","canonical_record":{"source":{"id":"2505.14725","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-19T19:37:49Z","cross_cats_sorted":["cs.LG","stat.AP"],"title_canon_sha256":"35100d6a9e689295cc238fdd34745c82e1daf74810771a23a98ab40969319bb0","abstract_canon_sha256":"f2d600dd1e82b4d6885bf9fabb70dc13f14b5629ba33bf19d4662c312589fc7c"},"schema_version":"1.0"},"canonical_sha256":"80c5d7d6c7f535b8f849ded87a5875ae35e0c8fadbba2a6a37a8641de4c8bef0","source":{"kind":"arxiv","id":"2505.14725","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.14725","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"arxiv_version","alias_value":"2505.14725v2","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.14725","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_12","alias_value":"QDC5PVWH6U23","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_16","alias_value":"QDC5PVWH6U23R6CJ","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_8","alias_value":"QDC5PVWH","created_at":"2026-06-02T01:04:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:QDC5PVWH6U23R6CJ33MHUWDVVY","target":"record","payload":{"canonical_record":{"source":{"id":"2505.14725","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-19T19:37:49Z","cross_cats_sorted":["cs.LG","stat.AP"],"title_canon_sha256":"35100d6a9e689295cc238fdd34745c82e1daf74810771a23a98ab40969319bb0","abstract_canon_sha256":"f2d600dd1e82b4d6885bf9fabb70dc13f14b5629ba33bf19d4662c312589fc7c"},"schema_version":"1.0"},"canonical_sha256":"80c5d7d6c7f535b8f849ded87a5875ae35e0c8fadbba2a6a37a8641de4c8bef0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-02T01:04:14.682905Z","signature_b64":"bak2A8Wz0OhHgB6LUvht8cLfACW341UGNyPs0BFVf0Rdp2S3zGI3f0c4pFbm4/7SsLv+3ljeIBFYWm+unP3mAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"80c5d7d6c7f535b8f849ded87a5875ae35e0c8fadbba2a6a37a8641de4c8bef0","last_reissued_at":"2026-06-02T01:04:14.682510Z","signature_status":"signed_v1","first_computed_at":"2026-06-02T01:04:14.682510Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.14725","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T01:04:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UX7jeNPfG8RNfy79qNzI8H04HRRthFf2oHoTL1ZljXfU9aJrQnXqZ+VW0RcWBDvlDgxXjcjJTtYGVCuQI/JBBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T15:58:07.024959Z"},"content_sha256":"cd356706a7e786d613028911ceee27c93004972433324596daad303163f41d69","schema_version":"1.0","event_id":"sha256:cd356706a7e786d613028911ceee27c93004972433324596daad303163f41d69"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:QDC5PVWH6U23R6CJ33MHUWDVVY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG","stat.AP"],"primary_cat":"q-bio.GN","authors_text":"Baiming Zou, Didong Li, Fei Zou, James S. Hagood, Jialiu Xie, Muyao Tang, Prem Lakshmanane, Raymond J. Pickles, Ruilie Cai, Rui Peng, Xiaochen Zhou, Xiaojing Zheng, Xinyi Li, Xuejun Sun, Yiran Song, Yuanyuan Yan, Yu Zhang","submitted_at":"2025-05-19T19:37:49Z","abstract_excerpt":"Respiratory viral infections pose a global health burden, yet the cellular immune mechanisms underlying protection and pathology remain unclear. Natural infection cohorts often lack pre-exposure baselines and time-controlled sampling, whereas inoculation and vaccination trials generate well-structured longitudinal transcriptomic data. However, these datasets are scattered across repositories and processed inconsistently, hindering integrative and AI-driven analyses. To address these challenges, we developed the Human Respiratory Viral Immunization LongitudinAl Gene Expression (HR-VILAGE-3K3M) "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.14725","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.14725/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-02T01:04:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"R8zS0l7CjzYbIUINgO0dXJEykSn4TgKqfCZxZVzQkRH6Lh3+wleWbq6GA7K61OBwj3LAZPqq7N8hoeHM1qAsBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T15:58:07.025777Z"},"content_sha256":"b5046a9199144dc282a18ff4bd247f66ffa0bcba09561d3542e3b28267b870ae","schema_version":"1.0","event_id":"sha256:b5046a9199144dc282a18ff4bd247f66ffa0bcba09561d3542e3b28267b870ae"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/bundle.json","state_url":"https://pith.science/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-08T15:58:07Z","links":{"resolver":"https://pith.science/pith/QDC5PVWH6U23R6CJ33MHUWDVVY","bundle":"https://pith.science/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/bundle.json","state":"https://pith.science/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QDC5PVWH6U23R6CJ33MHUWDVVY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:QDC5PVWH6U23R6CJ33MHUWDVVY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f2d600dd1e82b4d6885bf9fabb70dc13f14b5629ba33bf19d4662c312589fc7c","cross_cats_sorted":["cs.LG","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-19T19:37:49Z","title_canon_sha256":"35100d6a9e689295cc238fdd34745c82e1daf74810771a23a98ab40969319bb0"},"schema_version":"1.0","source":{"id":"2505.14725","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.14725","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"arxiv_version","alias_value":"2505.14725v2","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.14725","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_12","alias_value":"QDC5PVWH6U23","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_16","alias_value":"QDC5PVWH6U23R6CJ","created_at":"2026-06-02T01:04:14Z"},{"alias_kind":"pith_short_8","alias_value":"QDC5PVWH","created_at":"2026-06-02T01:04:14Z"}],"graph_snapshots":[{"event_id":"sha256:b5046a9199144dc282a18ff4bd247f66ffa0bcba09561d3542e3b28267b870ae","target":"graph","created_at":"2026-06-02T01:04:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.14725/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Respiratory viral infections pose a global health burden, yet the cellular immune mechanisms underlying protection and pathology remain unclear. Natural infection cohorts often lack pre-exposure baselines and time-controlled sampling, whereas inoculation and vaccination trials generate well-structured longitudinal transcriptomic data. However, these datasets are scattered across repositories and processed inconsistently, hindering integrative and AI-driven analyses. To address these challenges, we developed the Human Respiratory Viral Immunization LongitudinAl Gene Expression (HR-VILAGE-3K3M) ","authors_text":"Baiming Zou, Didong Li, Fei Zou, James S. Hagood, Jialiu Xie, Muyao Tang, Prem Lakshmanane, Raymond J. Pickles, Ruilie Cai, Rui Peng, Xiaochen Zhou, Xiaojing Zheng, Xinyi Li, Xuejun Sun, Yiran Song, Yuanyuan Yan, Yu Zhang","cross_cats":["cs.LG","stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-19T19:37:49Z","title":"HR-VILAGE-3K3M: A Human Respiratory Viral Immunization Longitudinal Gene Expression Dataset for Systems Immunity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.14725","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:cd356706a7e786d613028911ceee27c93004972433324596daad303163f41d69","target":"record","created_at":"2026-06-02T01:04:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f2d600dd1e82b4d6885bf9fabb70dc13f14b5629ba33bf19d4662c312589fc7c","cross_cats_sorted":["cs.LG","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-19T19:37:49Z","title_canon_sha256":"35100d6a9e689295cc238fdd34745c82e1daf74810771a23a98ab40969319bb0"},"schema_version":"1.0","source":{"id":"2505.14725","kind":"arxiv","version":2}},"canonical_sha256":"80c5d7d6c7f535b8f849ded87a5875ae35e0c8fadbba2a6a37a8641de4c8bef0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"80c5d7d6c7f535b8f849ded87a5875ae35e0c8fadbba2a6a37a8641de4c8bef0","first_computed_at":"2026-06-02T01:04:14.682510Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-02T01:04:14.682510Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bak2A8Wz0OhHgB6LUvht8cLfACW341UGNyPs0BFVf0Rdp2S3zGI3f0c4pFbm4/7SsLv+3ljeIBFYWm+unP3mAA==","signature_status":"signed_v1","signed_at":"2026-06-02T01:04:14.682905Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.14725","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:cd356706a7e786d613028911ceee27c93004972433324596daad303163f41d69","sha256:b5046a9199144dc282a18ff4bd247f66ffa0bcba09561d3542e3b28267b870ae"],"state_sha256":"863c60c2ca8527d4c08b5a1c6f5420829b77fec0211622ff9c55f064211a99ab"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CZYP5WvABTAGlZKSrwd1t46Ux2Xn2pkbbZFJuBaunyJrCrWE7baQQdaZrA09EYWVulYo5Mw5OIEqWoehG7R2DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-08T15:58:07.029938Z","bundle_sha256":"f7f912c3f041b204fb8ec47ac8916649dc81e450a1696c315bc1dd6f3efbb68b"}}