{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:QGN5CUHZCFQXVY5WY7ZTO5UXGF","short_pith_number":"pith:QGN5CUHZ","schema_version":"1.0","canonical_sha256":"819bd150f911617ae3b6c7f3377697317495d66507f46d136a9b25c1608765ee","source":{"kind":"arxiv","id":"1410.6064","version":7},"attestation_state":"computed","paper":{"title":"Antithetic Integral Feedback ensures robust perfect adaptation in noisy biomolecular networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.SY","math.PR","q-bio.MN"],"primary_cat":"math.OC","authors_text":"Ankit Gupta, Corentin Briat, Mustafa Khammash","submitted_at":"2014-10-22T15:02:05Z","abstract_excerpt":"Homeostasis is a running theme in biology. Often achieved through feedback regulation strategies, homeostasis allows living cells to control their internal environment as a means for surviving changing and unfavourable environments. While many endogenous homeostatic motifs have been studied in living cells, some other motifs may remain under-explored or even undiscovered. At the same time, known regulatory motifs have been mostly analyzed at the deterministic level, and the effect of noise on their regulatory function has received low attention. Here we lay the foundation for a regulation theo"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1410.6064","kind":"arxiv","version":7},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"math.OC","submitted_at":"2014-10-22T15:02:05Z","cross_cats_sorted":["cs.SY","math.PR","q-bio.MN"],"title_canon_sha256":"009bb8c618ed1b6be7d548360b4cc365bf9a075d6590fcc0fe43a8d4b76ec5fb","abstract_canon_sha256":"3b9859741be43cbc3d6077f87285763fec1f8263b55986bf8e7558ec4a6d8e3b"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:21:45.175948Z","signature_b64":"zhRWUmC/QuCA73Kg367mjHwJXfm6rtSQtNvetpGeipDZZKMAIq0QoxC6ggnqf5CQwChQZxlMXwZVB3BrmOkvBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"819bd150f911617ae3b6c7f3377697317495d66507f46d136a9b25c1608765ee","last_reissued_at":"2026-05-18T01:21:45.175239Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:21:45.175239Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Antithetic Integral Feedback ensures robust perfect adaptation in noisy biomolecular networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.SY","math.PR","q-bio.MN"],"primary_cat":"math.OC","authors_text":"Ankit Gupta, Corentin Briat, Mustafa Khammash","submitted_at":"2014-10-22T15:02:05Z","abstract_excerpt":"Homeostasis is a running theme in biology. Often achieved through feedback regulation strategies, homeostasis allows living cells to control their internal environment as a means for surviving changing and unfavourable environments. While many endogenous homeostatic motifs have been studied in living cells, some other motifs may remain under-explored or even undiscovered. At the same time, known regulatory motifs have been mostly analyzed at the deterministic level, and the effect of noise on their regulatory function has received low attention. Here we lay the foundation for a regulation theo"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1410.6064","kind":"arxiv","version":7},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1410.6064","created_at":"2026-05-18T01:21:45.175337+00:00"},{"alias_kind":"arxiv_version","alias_value":"1410.6064v7","created_at":"2026-05-18T01:21:45.175337+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1410.6064","created_at":"2026-05-18T01:21:45.175337+00:00"},{"alias_kind":"pith_short_12","alias_value":"QGN5CUHZCFQX","created_at":"2026-05-18T12:28:46.137349+00:00"},{"alias_kind":"pith_short_16","alias_value":"QGN5CUHZCFQXVY5W","created_at":"2026-05-18T12:28:46.137349+00:00"},{"alias_kind":"pith_short_8","alias_value":"QGN5CUHZ","created_at":"2026-05-18T12:28:46.137349+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF","json":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF.json","graph_json":"https://pith.science/api/pith-number/QGN5CUHZCFQXVY5WY7ZTO5UXGF/graph.json","events_json":"https://pith.science/api/pith-number/QGN5CUHZCFQXVY5WY7ZTO5UXGF/events.json","paper":"https://pith.science/paper/QGN5CUHZ"},"agent_actions":{"view_html":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF","download_json":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF.json","view_paper":"https://pith.science/paper/QGN5CUHZ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1410.6064&json=true","fetch_graph":"https://pith.science/api/pith-number/QGN5CUHZCFQXVY5WY7ZTO5UXGF/graph.json","fetch_events":"https://pith.science/api/pith-number/QGN5CUHZCFQXVY5WY7ZTO5UXGF/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF/action/timestamp_anchor","attest_storage":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF/action/storage_attestation","attest_author":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF/action/author_attestation","sign_citation":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF/action/citation_signature","submit_replication":"https://pith.science/pith/QGN5CUHZCFQXVY5WY7ZTO5UXGF/action/replication_record"}},"created_at":"2026-05-18T01:21:45.175337+00:00","updated_at":"2026-05-18T01:21:45.175337+00:00"}