{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:QHEF7AWWOJZG624QHAXHPWKBVM","short_pith_number":"pith:QHEF7AWW","canonical_record":{"source":{"id":"2104.12862","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-04-16T19:45:00Z","cross_cats_sorted":["cs.CV","cs.LG"],"title_canon_sha256":"00c22d91715f1a8eb18d5721a9bc229f0d8b35b0effad4ea5b651ec140aa5380","abstract_canon_sha256":"6cd6d3f9cc159b365e5a49976917c2006a9167efab64f717f851c9c1d6f4e2fa"},"schema_version":"1.0"},"canonical_sha256":"81c85f82d672726f6b90382e77d941ab080005ce332bfa65ebcdeaed30825d24","source":{"kind":"arxiv","id":"2104.12862","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2104.12862","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"arxiv_version","alias_value":"2104.12862v1","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2104.12862","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_12","alias_value":"QHEF7AWWOJZG","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_16","alias_value":"QHEF7AWWOJZG624Q","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_8","alias_value":"QHEF7AWW","created_at":"2026-07-05T02:35:03Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:QHEF7AWWOJZG624QHAXHPWKBVM","target":"record","payload":{"canonical_record":{"source":{"id":"2104.12862","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-04-16T19:45:00Z","cross_cats_sorted":["cs.CV","cs.LG"],"title_canon_sha256":"00c22d91715f1a8eb18d5721a9bc229f0d8b35b0effad4ea5b651ec140aa5380","abstract_canon_sha256":"6cd6d3f9cc159b365e5a49976917c2006a9167efab64f717f851c9c1d6f4e2fa"},"schema_version":"1.0"},"canonical_sha256":"81c85f82d672726f6b90382e77d941ab080005ce332bfa65ebcdeaed30825d24","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:35:03.601360Z","signature_b64":"3w70cigwIns1kMz2EkOEVgDt0TvuYBo8+I5j3Q6taoYAYi1co+ZSXrNr0T89knfspAOuaVbN0TEvx9g0DAgJBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"81c85f82d672726f6b90382e77d941ab080005ce332bfa65ebcdeaed30825d24","last_reissued_at":"2026-07-05T02:35:03.600891Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:35:03.600891Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2104.12862","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:35:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+HrwaZiCsthysO08UJB4NtvTo9ycNFSkE3Nv6tmIhXXFN6wRDYJmt0rpLf7FDtTPmSC2peYmWimJbwKyHeY5Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T13:56:34.121445Z"},"content_sha256":"ce3cfcbdd9c6436eb92b957ff3141af991b5eae518604e409998476c9a064144","schema_version":"1.0","event_id":"sha256:ce3cfcbdd9c6436eb92b957ff3141af991b5eae518604e409998476c9a064144"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:QHEF7AWWOJZG624QHAXHPWKBVM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CV","cs.LG"],"primary_cat":"eess.IV","authors_text":"Arif Jamshed, Asif Loya, Hisham Mehanna, Jill Brooks, Mariam Hassan, Max Robinson, Muhammad Shaban, Nasir Rajpoot, Neil Sharma, Nikolaos Batis, Paul Nankivell, Sajid Mushtaq, Shan E Ahmed Raza, Syed Ali Khurram","submitted_at":"2021-04-16T19:45:00Z","abstract_excerpt":"The infiltration of T-lymphocytes in the stroma and tumour is an indication of an effective immune response against the tumour, resulting in better survival. In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method. A deep learning based automated method was employed to segment tumour, stroma and lymphocytes in digitally scanned whole slide images of HNSCC tissue slides. The spatial patterns of lymphocytes and tumour-associated stroma were "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2104.12862","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2104.12862/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:35:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1RQqD2uGwUIyff41LulsSRGsEZgko/adXH+mKUi87WvVIU7HdA9Fj6O1aBR++HYupEGgl4OsjFNvPX3AofwmCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-08T13:56:34.122396Z"},"content_sha256":"a6f267e170452ebd749a3a5f820f57065c5133358cf1139f6822688bab1f4413","schema_version":"1.0","event_id":"sha256:a6f267e170452ebd749a3a5f820f57065c5133358cf1139f6822688bab1f4413"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QHEF7AWWOJZG624QHAXHPWKBVM/bundle.json","state_url":"https://pith.science/pith/QHEF7AWWOJZG624QHAXHPWKBVM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QHEF7AWWOJZG624QHAXHPWKBVM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-08T13:56:34Z","links":{"resolver":"https://pith.science/pith/QHEF7AWWOJZG624QHAXHPWKBVM","bundle":"https://pith.science/pith/QHEF7AWWOJZG624QHAXHPWKBVM/bundle.json","state":"https://pith.science/pith/QHEF7AWWOJZG624QHAXHPWKBVM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QHEF7AWWOJZG624QHAXHPWKBVM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:QHEF7AWWOJZG624QHAXHPWKBVM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6cd6d3f9cc159b365e5a49976917c2006a9167efab64f717f851c9c1d6f4e2fa","cross_cats_sorted":["cs.CV","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-04-16T19:45:00Z","title_canon_sha256":"00c22d91715f1a8eb18d5721a9bc229f0d8b35b0effad4ea5b651ec140aa5380"},"schema_version":"1.0","source":{"id":"2104.12862","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2104.12862","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"arxiv_version","alias_value":"2104.12862v1","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2104.12862","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_12","alias_value":"QHEF7AWWOJZG","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_16","alias_value":"QHEF7AWWOJZG624Q","created_at":"2026-07-05T02:35:03Z"},{"alias_kind":"pith_short_8","alias_value":"QHEF7AWW","created_at":"2026-07-05T02:35:03Z"}],"graph_snapshots":[{"event_id":"sha256:a6f267e170452ebd749a3a5f820f57065c5133358cf1139f6822688bab1f4413","target":"graph","created_at":"2026-07-05T02:35:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2104.12862/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The infiltration of T-lymphocytes in the stroma and tumour is an indication of an effective immune response against the tumour, resulting in better survival. In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method. A deep learning based automated method was employed to segment tumour, stroma and lymphocytes in digitally scanned whole slide images of HNSCC tissue slides. The spatial patterns of lymphocytes and tumour-associated stroma were ","authors_text":"Arif Jamshed, Asif Loya, Hisham Mehanna, Jill Brooks, Mariam Hassan, Max Robinson, Muhammad Shaban, Nasir Rajpoot, Neil Sharma, Nikolaos Batis, Paul Nankivell, Sajid Mushtaq, Shan E Ahmed Raza, Syed Ali Khurram","cross_cats":["cs.CV","cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-04-16T19:45:00Z","title":"A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2104.12862","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ce3cfcbdd9c6436eb92b957ff3141af991b5eae518604e409998476c9a064144","target":"record","created_at":"2026-07-05T02:35:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6cd6d3f9cc159b365e5a49976917c2006a9167efab64f717f851c9c1d6f4e2fa","cross_cats_sorted":["cs.CV","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"eess.IV","submitted_at":"2021-04-16T19:45:00Z","title_canon_sha256":"00c22d91715f1a8eb18d5721a9bc229f0d8b35b0effad4ea5b651ec140aa5380"},"schema_version":"1.0","source":{"id":"2104.12862","kind":"arxiv","version":1}},"canonical_sha256":"81c85f82d672726f6b90382e77d941ab080005ce332bfa65ebcdeaed30825d24","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"81c85f82d672726f6b90382e77d941ab080005ce332bfa65ebcdeaed30825d24","first_computed_at":"2026-07-05T02:35:03.600891Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:35:03.600891Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3w70cigwIns1kMz2EkOEVgDt0TvuYBo8+I5j3Q6taoYAYi1co+ZSXrNr0T89knfspAOuaVbN0TEvx9g0DAgJBw==","signature_status":"signed_v1","signed_at":"2026-07-05T02:35:03.601360Z","signed_message":"canonical_sha256_bytes"},"source_id":"2104.12862","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ce3cfcbdd9c6436eb92b957ff3141af991b5eae518604e409998476c9a064144","sha256:a6f267e170452ebd749a3a5f820f57065c5133358cf1139f6822688bab1f4413"],"state_sha256":"0b57176f1f6d32ab99a144f26f5c51219046a100d852e765858a4e23619d9675"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1YqufYA7eSPkiXV4fc+nRJHlwLauQGhn9U4uzkoc3UqJ81xkG7lUBPmJByu7kdUobBeuONGD7VLJsMnQPq3BBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-08T13:56:34.129208Z","bundle_sha256":"7a9c39f61653396d388143bbaad32a574c16c71736a809178ded9db395c08090"}}