{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:QLFJ5VY5HALEL2DV36DMTAI7YD","short_pith_number":"pith:QLFJ5VY5","schema_version":"1.0","canonical_sha256":"82ca9ed71d381645e875df86c9811fc0fad3d9d11f8a8d996548321df003cb0c","source":{"kind":"arxiv","id":"1612.02116","version":1},"attestation_state":"computed","paper":{"title":"Signal Manifestation Trade-offs in Incoherent Feed-Forward Loops","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Tarunendu Mapder","submitted_at":"2016-12-07T05:18:04Z","abstract_excerpt":"Signal processing in biological systems is delicately executed by specialised networks, which are modular assemblies of network motifs. The motifs are independently functional circuits found in enormous numbers in any living cell. A very common network motif is the feed-forward loop (FFL), which regulates a downstream node by an upstream one in a direct and an indirect way within the network. If the direct and indirect regulations go antagonistic, the motif is known as an incoherent FFL (ICFFL). The current study is aimed at exploring the reason for the variation in the evolutionary selection "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1612.02116","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-12-07T05:18:04Z","cross_cats_sorted":[],"title_canon_sha256":"d3df0e09c21213c570592c287c6e3c2054512f807d02436a063821c7bf767f15","abstract_canon_sha256":"9e9696853135bcde9dd5c8ae130418d11a7cdaeeb8b4552232235a4f78843a97"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:55:35.301371Z","signature_b64":"ZuFxeb6Lg9T6EU+qhkCT/LEDg42AlPmHfNAf8rQcMA3ldpZFyR89RdtpgOdhcOgp3LwQUEpOfUKBmV+WqdlHAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"82ca9ed71d381645e875df86c9811fc0fad3d9d11f8a8d996548321df003cb0c","last_reissued_at":"2026-05-18T00:55:35.300852Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:55:35.300852Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Signal Manifestation Trade-offs in Incoherent Feed-Forward Loops","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Tarunendu Mapder","submitted_at":"2016-12-07T05:18:04Z","abstract_excerpt":"Signal processing in biological systems is delicately executed by specialised networks, which are modular assemblies of network motifs. The motifs are independently functional circuits found in enormous numbers in any living cell. A very common network motif is the feed-forward loop (FFL), which regulates a downstream node by an upstream one in a direct and an indirect way within the network. If the direct and indirect regulations go antagonistic, the motif is known as an incoherent FFL (ICFFL). The current study is aimed at exploring the reason for the variation in the evolutionary selection "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1612.02116","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1612.02116","created_at":"2026-05-18T00:55:35.300945+00:00"},{"alias_kind":"arxiv_version","alias_value":"1612.02116v1","created_at":"2026-05-18T00:55:35.300945+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1612.02116","created_at":"2026-05-18T00:55:35.300945+00:00"},{"alias_kind":"pith_short_12","alias_value":"QLFJ5VY5HALE","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_16","alias_value":"QLFJ5VY5HALEL2DV","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_8","alias_value":"QLFJ5VY5","created_at":"2026-05-18T12:30:39.010887+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD","json":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD.json","graph_json":"https://pith.science/api/pith-number/QLFJ5VY5HALEL2DV36DMTAI7YD/graph.json","events_json":"https://pith.science/api/pith-number/QLFJ5VY5HALEL2DV36DMTAI7YD/events.json","paper":"https://pith.science/paper/QLFJ5VY5"},"agent_actions":{"view_html":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD","download_json":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD.json","view_paper":"https://pith.science/paper/QLFJ5VY5","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1612.02116&json=true","fetch_graph":"https://pith.science/api/pith-number/QLFJ5VY5HALEL2DV36DMTAI7YD/graph.json","fetch_events":"https://pith.science/api/pith-number/QLFJ5VY5HALEL2DV36DMTAI7YD/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD/action/timestamp_anchor","attest_storage":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD/action/storage_attestation","attest_author":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD/action/author_attestation","sign_citation":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD/action/citation_signature","submit_replication":"https://pith.science/pith/QLFJ5VY5HALEL2DV36DMTAI7YD/action/replication_record"}},"created_at":"2026-05-18T00:55:35.300945+00:00","updated_at":"2026-05-18T00:55:35.300945+00:00"}