{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:QO3TL23I5PH5Q242C7U4TI4VLW","short_pith_number":"pith:QO3TL23I","canonical_record":{"source":{"id":"2403.03274","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-03-05T19:13:57Z","cross_cats_sorted":["cs.AI","cs.LG","math.DS"],"title_canon_sha256":"186c0828a419f265e44a894b19a90be5db75705cde62965b0e35acbc97c42d3c","abstract_canon_sha256":"183152458777fac350d7b7a9153a3f3f11fe5b89a01ce8cfef52d49974606ecb"},"schema_version":"1.0"},"canonical_sha256":"83b735eb68ebcfd86b9a17e9c9a3955dae856b3e7266bd51465c6128261f65fa","source":{"kind":"arxiv","id":"2403.03274","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2403.03274","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"arxiv_version","alias_value":"2403.03274v1","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2403.03274","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_12","alias_value":"QO3TL23I5PH5","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_16","alias_value":"QO3TL23I5PH5Q242","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_8","alias_value":"QO3TL23I","created_at":"2026-07-05T07:52:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:QO3TL23I5PH5Q242C7U4TI4VLW","target":"record","payload":{"canonical_record":{"source":{"id":"2403.03274","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-03-05T19:13:57Z","cross_cats_sorted":["cs.AI","cs.LG","math.DS"],"title_canon_sha256":"186c0828a419f265e44a894b19a90be5db75705cde62965b0e35acbc97c42d3c","abstract_canon_sha256":"183152458777fac350d7b7a9153a3f3f11fe5b89a01ce8cfef52d49974606ecb"},"schema_version":"1.0"},"canonical_sha256":"83b735eb68ebcfd86b9a17e9c9a3955dae856b3e7266bd51465c6128261f65fa","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:52:46.129894Z","signature_b64":"7lkk/Tkhq4acEWm5zgpQ33hfwxRugfN7nWHZX5O9ArWjO9bMwqHIGZUgIJ863R0cfSRcB5Xrx5jHp9Um8/b3BA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"83b735eb68ebcfd86b9a17e9c9a3955dae856b3e7266bd51465c6128261f65fa","last_reissued_at":"2026-07-05T07:52:46.129530Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:52:46.129530Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2403.03274","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:52:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"lc2a6CRApOS5QXZnFTVN+b9EsXah53vsr6qkXXt0fDz2poTtDioD7vxR/vfkQ/15mz+XQN7COclcXiuj32apAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-10T15:03:26.337243Z"},"content_sha256":"214ff0243413ab2c67a4d2646edb510442d3ef183be7327a17a7fe24b1c73bf1","schema_version":"1.0","event_id":"sha256:214ff0243413ab2c67a4d2646edb510442d3ef183be7327a17a7fe24b1c73bf1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:QO3TL23I5PH5Q242C7U4TI4VLW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"From Noise to Signal: Unveiling Treatment Effects from Digital Health Data through Pharmacology-Informed Neural-SDE","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["cs.AI","cs.LG","math.DS"],"primary_cat":"q-bio.QM","authors_text":"James Lu, Logan Brooks, Maxime Usdin, Nikolaos Evangelou, Samira Pakravan","submitted_at":"2024-03-05T19:13:57Z","abstract_excerpt":"Digital health technologies (DHT), such as wearable devices, provide personalized, continuous, and real-time monitoring of patient. These technologies are contributing to the development of novel therapies and personalized medicine. Gaining insight from these technologies requires appropriate modeling techniques to capture clinically-relevant changes in disease state. The data generated from these devices is characterized by being stochastic in nature, may have missing elements, and exhibits considerable inter-individual variability - thereby making it difficult to analyze using traditional lo"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2403.03274","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2403.03274/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:52:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+RbR4bPmISQZ79IYm+pl1dB+nYt0RsAAbIUh9DZSd+4VsIicvbmTXuReQ2ATjSH2OqpRFfbWorxg8OZrD7jYBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-10T15:03:26.337814Z"},"content_sha256":"d0257abfc6ce51395dd995d716fae4c423d28f3d843ad9167350d922e44040cb","schema_version":"1.0","event_id":"sha256:d0257abfc6ce51395dd995d716fae4c423d28f3d843ad9167350d922e44040cb"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QO3TL23I5PH5Q242C7U4TI4VLW/bundle.json","state_url":"https://pith.science/pith/QO3TL23I5PH5Q242C7U4TI4VLW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QO3TL23I5PH5Q242C7U4TI4VLW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-10T15:03:26Z","links":{"resolver":"https://pith.science/pith/QO3TL23I5PH5Q242C7U4TI4VLW","bundle":"https://pith.science/pith/QO3TL23I5PH5Q242C7U4TI4VLW/bundle.json","state":"https://pith.science/pith/QO3TL23I5PH5Q242C7U4TI4VLW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QO3TL23I5PH5Q242C7U4TI4VLW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:QO3TL23I5PH5Q242C7U4TI4VLW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"183152458777fac350d7b7a9153a3f3f11fe5b89a01ce8cfef52d49974606ecb","cross_cats_sorted":["cs.AI","cs.LG","math.DS"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-03-05T19:13:57Z","title_canon_sha256":"186c0828a419f265e44a894b19a90be5db75705cde62965b0e35acbc97c42d3c"},"schema_version":"1.0","source":{"id":"2403.03274","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2403.03274","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"arxiv_version","alias_value":"2403.03274v1","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2403.03274","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_12","alias_value":"QO3TL23I5PH5","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_16","alias_value":"QO3TL23I5PH5Q242","created_at":"2026-07-05T07:52:46Z"},{"alias_kind":"pith_short_8","alias_value":"QO3TL23I","created_at":"2026-07-05T07:52:46Z"}],"graph_snapshots":[{"event_id":"sha256:d0257abfc6ce51395dd995d716fae4c423d28f3d843ad9167350d922e44040cb","target":"graph","created_at":"2026-07-05T07:52:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2403.03274/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Digital health technologies (DHT), such as wearable devices, provide personalized, continuous, and real-time monitoring of patient. These technologies are contributing to the development of novel therapies and personalized medicine. Gaining insight from these technologies requires appropriate modeling techniques to capture clinically-relevant changes in disease state. The data generated from these devices is characterized by being stochastic in nature, may have missing elements, and exhibits considerable inter-individual variability - thereby making it difficult to analyze using traditional lo","authors_text":"James Lu, Logan Brooks, Maxime Usdin, Nikolaos Evangelou, Samira Pakravan","cross_cats":["cs.AI","cs.LG","math.DS"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-03-05T19:13:57Z","title":"From Noise to Signal: Unveiling Treatment Effects from Digital Health Data through Pharmacology-Informed Neural-SDE"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2403.03274","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:214ff0243413ab2c67a4d2646edb510442d3ef183be7327a17a7fe24b1c73bf1","target":"record","created_at":"2026-07-05T07:52:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"183152458777fac350d7b7a9153a3f3f11fe5b89a01ce8cfef52d49974606ecb","cross_cats_sorted":["cs.AI","cs.LG","math.DS"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-03-05T19:13:57Z","title_canon_sha256":"186c0828a419f265e44a894b19a90be5db75705cde62965b0e35acbc97c42d3c"},"schema_version":"1.0","source":{"id":"2403.03274","kind":"arxiv","version":1}},"canonical_sha256":"83b735eb68ebcfd86b9a17e9c9a3955dae856b3e7266bd51465c6128261f65fa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"83b735eb68ebcfd86b9a17e9c9a3955dae856b3e7266bd51465c6128261f65fa","first_computed_at":"2026-07-05T07:52:46.129530Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:52:46.129530Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"7lkk/Tkhq4acEWm5zgpQ33hfwxRugfN7nWHZX5O9ArWjO9bMwqHIGZUgIJ863R0cfSRcB5Xrx5jHp9Um8/b3BA==","signature_status":"signed_v1","signed_at":"2026-07-05T07:52:46.129894Z","signed_message":"canonical_sha256_bytes"},"source_id":"2403.03274","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:214ff0243413ab2c67a4d2646edb510442d3ef183be7327a17a7fe24b1c73bf1","sha256:d0257abfc6ce51395dd995d716fae4c423d28f3d843ad9167350d922e44040cb"],"state_sha256":"7493d64817a1dcc06a910a4cbefad85128d73699831eaef0faf09f70f5f7bb41"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0Txp0hCKkJkjJLgoFm2Bbl699qDszP6ol2OrtLWIS44XJMVLM/gzQC5kcOrdcM+z0eKgKQQ9MwOyY1RVR9buDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-10T15:03:26.341438Z","bundle_sha256":"42983bd472d076b324051fea62ee2574ee1817786a8c8f77b2303b5521579ca7"}}