{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:QOBRXI2UHUIPKVON3IV5PF7VWD","short_pith_number":"pith:QOBRXI2U","schema_version":"1.0","canonical_sha256":"83831ba3543d10f555cdda2bd797f5b0f8a204b31fdb1b9514ce492aa4091999","source":{"kind":"arxiv","id":"1607.08507","version":1},"attestation_state":"computed","paper":{"title":"Mitochondrial Ca2+ uptake in skeletal muscle health and disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"q-bio.BM","authors_text":"Jianxun Yi, Jingsong Zhou, Kamal Dhakal","submitted_at":"2016-07-28T15:47:22Z","abstract_excerpt":"Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake. Under physiological conditions, Ca2+ uptake into mitochondria promotes ATP production. Excessive uptake causes mitochondrial Ca2+ overload, which activates downstream adverse responses leading to cell dysfunction. Moreover, mitochondrial Ca2+ uptake could shape spatio-temp"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1607.08507","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-07-28T15:47:22Z","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"title_canon_sha256":"ac584a5b21d348d99b4ac31971651ce73c503bd6ab50132b15451f30a994431b","abstract_canon_sha256":"8d24e5f2388412dfd6299a5c4fe9cb09eb82e99e9284f9bd966dfd86ef46d8b6"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:10:18.983250Z","signature_b64":"1Oe6wbgxrI3TAAJeDkSUWkG18tQ88ax3er51AeL4HYAqk1pYo9iBpoW3hknF695e5RO6vweTat2Ec9jz8dVrBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"83831ba3543d10f555cdda2bd797f5b0f8a204b31fdb1b9514ce492aa4091999","last_reissued_at":"2026-05-18T01:10:18.982689Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:10:18.982689Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Mitochondrial Ca2+ uptake in skeletal muscle health and disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"q-bio.BM","authors_text":"Jianxun Yi, Jingsong Zhou, Kamal Dhakal","submitted_at":"2016-07-28T15:47:22Z","abstract_excerpt":"Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+ uptake. Under physiological conditions, Ca2+ uptake into mitochondria promotes ATP production. Excessive uptake causes mitochondrial Ca2+ overload, which activates downstream adverse responses leading to cell dysfunction. Moreover, mitochondrial Ca2+ uptake could shape spatio-temp"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1607.08507","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1607.08507","created_at":"2026-05-18T01:10:18.982793+00:00"},{"alias_kind":"arxiv_version","alias_value":"1607.08507v1","created_at":"2026-05-18T01:10:18.982793+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1607.08507","created_at":"2026-05-18T01:10:18.982793+00:00"},{"alias_kind":"pith_short_12","alias_value":"QOBRXI2UHUIP","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_16","alias_value":"QOBRXI2UHUIPKVON","created_at":"2026-05-18T12:30:39.010887+00:00"},{"alias_kind":"pith_short_8","alias_value":"QOBRXI2U","created_at":"2026-05-18T12:30:39.010887+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD","json":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD.json","graph_json":"https://pith.science/api/pith-number/QOBRXI2UHUIPKVON3IV5PF7VWD/graph.json","events_json":"https://pith.science/api/pith-number/QOBRXI2UHUIPKVON3IV5PF7VWD/events.json","paper":"https://pith.science/paper/QOBRXI2U"},"agent_actions":{"view_html":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD","download_json":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD.json","view_paper":"https://pith.science/paper/QOBRXI2U","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1607.08507&json=true","fetch_graph":"https://pith.science/api/pith-number/QOBRXI2UHUIPKVON3IV5PF7VWD/graph.json","fetch_events":"https://pith.science/api/pith-number/QOBRXI2UHUIPKVON3IV5PF7VWD/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD/action/timestamp_anchor","attest_storage":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD/action/storage_attestation","attest_author":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD/action/author_attestation","sign_citation":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD/action/citation_signature","submit_replication":"https://pith.science/pith/QOBRXI2UHUIPKVON3IV5PF7VWD/action/replication_record"}},"created_at":"2026-05-18T01:10:18.982793+00:00","updated_at":"2026-05-18T01:10:18.982793+00:00"}