{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:QQD3ZDRBU2D6RSETGXGXKCDPDF","short_pith_number":"pith:QQD3ZDRB","canonical_record":{"source":{"id":"0911.4074","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2009-11-20T16:22:38Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"733971911df21fab3d5b8ee51de22bca2a2365c59aed18d9d13ccd4614540ef5","abstract_canon_sha256":"0e2134d448e074419a8315b82dafc8bd4b32cf00ff61badaf296b4fbeed422cc"},"schema_version":"1.0"},"canonical_sha256":"8407bc8e21a687e8c89335cd75086f195d0c8d48595436c177d2e66b672e66af","source":{"kind":"arxiv","id":"0911.4074","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0911.4074","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"arxiv_version","alias_value":"0911.4074v2","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0911.4074","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"pith_short_12","alias_value":"QQD3ZDRBU2D6","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"QQD3ZDRBU2D6RSET","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"QQD3ZDRB","created_at":"2026-05-18T12:26:01Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:QQD3ZDRBU2D6RSETGXGXKCDPDF","target":"record","payload":{"canonical_record":{"source":{"id":"0911.4074","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2009-11-20T16:22:38Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"733971911df21fab3d5b8ee51de22bca2a2365c59aed18d9d13ccd4614540ef5","abstract_canon_sha256":"0e2134d448e074419a8315b82dafc8bd4b32cf00ff61badaf296b4fbeed422cc"},"schema_version":"1.0"},"canonical_sha256":"8407bc8e21a687e8c89335cd75086f195d0c8d48595436c177d2e66b672e66af","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:10:45.406173Z","signature_b64":"xdbwQ1JC6sLGgXiED4eKkvPG3Cv5xxcukNGcsjzLIGCCF1J4RtCrFIcQR/zi9cyAF7Fc1EDG+ZT3pAtTTEG3Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"8407bc8e21a687e8c89335cd75086f195d0c8d48595436c177d2e66b672e66af","last_reissued_at":"2026-05-18T02:10:45.405406Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:10:45.405406Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0911.4074","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:10:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DJxgl728YptfTpKUqWaclGfnW3Koc3uiqDKRgu/9FV0+FBICmLz/h+RqixFHGRajaoj6XHNIiVmcs5SGwwsqDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T01:13:51.569636Z"},"content_sha256":"9f11ebc9f3d5b37c6116580829f2bd5b2a65289d8d1c5e1501252b2ec7ef193d","schema_version":"1.0","event_id":"sha256:9f11ebc9f3d5b37c6116580829f2bd5b2a65289d8d1c5e1501252b2ec7ef193d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:QQD3ZDRBU2D6RSETGXGXKCDPDF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Photodynamic therapy influence on anti-cancer immunity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"q-bio.CB","authors_text":"O.G. Isaeva, V.A. Osipov","submitted_at":"2009-11-20T16:22:38Z","abstract_excerpt":"The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of interleukin-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0911.4074","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:10:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PKbmlvlFiO3uacJ29MlxW/v253Um+F1NzU01LrEWdaSipIGFFFbcDsyWm/2ZnzCKR4+smvYuj1N3K4bIJkG2Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T01:13:51.569981Z"},"content_sha256":"4b6cda827869abb5aafb4a97f6927853151895f0c548d9a9d6dfc5414922768c","schema_version":"1.0","event_id":"sha256:4b6cda827869abb5aafb4a97f6927853151895f0c548d9a9d6dfc5414922768c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/bundle.json","state_url":"https://pith.science/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T01:13:51Z","links":{"resolver":"https://pith.science/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF","bundle":"https://pith.science/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/bundle.json","state":"https://pith.science/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QQD3ZDRBU2D6RSETGXGXKCDPDF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:QQD3ZDRBU2D6RSETGXGXKCDPDF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0e2134d448e074419a8315b82dafc8bd4b32cf00ff61badaf296b4fbeed422cc","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2009-11-20T16:22:38Z","title_canon_sha256":"733971911df21fab3d5b8ee51de22bca2a2365c59aed18d9d13ccd4614540ef5"},"schema_version":"1.0","source":{"id":"0911.4074","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0911.4074","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"arxiv_version","alias_value":"0911.4074v2","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0911.4074","created_at":"2026-05-18T02:10:45Z"},{"alias_kind":"pith_short_12","alias_value":"QQD3ZDRBU2D6","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_16","alias_value":"QQD3ZDRBU2D6RSET","created_at":"2026-05-18T12:26:01Z"},{"alias_kind":"pith_short_8","alias_value":"QQD3ZDRB","created_at":"2026-05-18T12:26:01Z"}],"graph_snapshots":[{"event_id":"sha256:4b6cda827869abb5aafb4a97f6927853151895f0c548d9a9d6dfc5414922768c","target":"graph","created_at":"2026-05-18T02:10:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of interleukin-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce t","authors_text":"O.G. Isaeva, V.A. Osipov","cross_cats":["q-bio.PE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2009-11-20T16:22:38Z","title":"Photodynamic therapy influence on anti-cancer immunity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0911.4074","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9f11ebc9f3d5b37c6116580829f2bd5b2a65289d8d1c5e1501252b2ec7ef193d","target":"record","created_at":"2026-05-18T02:10:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0e2134d448e074419a8315b82dafc8bd4b32cf00ff61badaf296b4fbeed422cc","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2009-11-20T16:22:38Z","title_canon_sha256":"733971911df21fab3d5b8ee51de22bca2a2365c59aed18d9d13ccd4614540ef5"},"schema_version":"1.0","source":{"id":"0911.4074","kind":"arxiv","version":2}},"canonical_sha256":"8407bc8e21a687e8c89335cd75086f195d0c8d48595436c177d2e66b672e66af","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8407bc8e21a687e8c89335cd75086f195d0c8d48595436c177d2e66b672e66af","first_computed_at":"2026-05-18T02:10:45.405406Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:10:45.405406Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xdbwQ1JC6sLGgXiED4eKkvPG3Cv5xxcukNGcsjzLIGCCF1J4RtCrFIcQR/zi9cyAF7Fc1EDG+ZT3pAtTTEG3Aw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:10:45.406173Z","signed_message":"canonical_sha256_bytes"},"source_id":"0911.4074","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9f11ebc9f3d5b37c6116580829f2bd5b2a65289d8d1c5e1501252b2ec7ef193d","sha256:4b6cda827869abb5aafb4a97f6927853151895f0c548d9a9d6dfc5414922768c"],"state_sha256":"527e34e4bc60ee79c5d12e465b9753da7cae68f78f5dfe4156cdf17c0aa5d7e3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JpSGrSSm0dwzht9NCnVy05xJOzTgM+TQ1uHAa28gJNAHOhgqvoCMqOAa2cclYvstfscrbFhEyLAsWeqqgs6+Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T01:13:51.571957Z","bundle_sha256":"19d57e7ba3b8367877bb440137930a4b9f28a10e0e63a6ce0df32b1a8589f1b3"}}