{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:QRFPEQSBIUS5AETVJVF46GMRPS","short_pith_number":"pith:QRFPEQSB","canonical_record":{"source":{"id":"1010.1092","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2010-10-06T08:58:16Z","cross_cats_sorted":[],"title_canon_sha256":"c73969d35b10190376a650a2bd0d6da9e0b44894feca0f6e4ecefe8e5f38f5f0","abstract_canon_sha256":"41df754ed2c1f86ca0244c679d861881a410629a4dabd4129ef7b7a608a9c5cc"},"schema_version":"1.0"},"canonical_sha256":"844af242414525d012754d4bcf19917cbe4edb76184601293812afdc690cba5e","source":{"kind":"arxiv","id":"1010.1092","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1010.1092","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"arxiv_version","alias_value":"1010.1092v1","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1010.1092","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"pith_short_12","alias_value":"QRFPEQSBIUS5","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"QRFPEQSBIUS5AETV","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"QRFPEQSB","created_at":"2026-05-18T12:26:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:QRFPEQSBIUS5AETVJVF46GMRPS","target":"record","payload":{"canonical_record":{"source":{"id":"1010.1092","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2010-10-06T08:58:16Z","cross_cats_sorted":[],"title_canon_sha256":"c73969d35b10190376a650a2bd0d6da9e0b44894feca0f6e4ecefe8e5f38f5f0","abstract_canon_sha256":"41df754ed2c1f86ca0244c679d861881a410629a4dabd4129ef7b7a608a9c5cc"},"schema_version":"1.0"},"canonical_sha256":"844af242414525d012754d4bcf19917cbe4edb76184601293812afdc690cba5e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:39:49.848594Z","signature_b64":"ufKOqpwYBQqc5bySHvsNojCOUfONEnPnIQbky72g6JvzWWsIzgZMRR0TzM0RX2XlRPYEGBMd+pKzSZ7xir44Dg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"844af242414525d012754d4bcf19917cbe4edb76184601293812afdc690cba5e","last_reissued_at":"2026-05-18T04:39:49.848177Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:39:49.848177Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1010.1092","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:39:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pzLkDxciTibJTz2vzqUflTmquC2fl5dCeKkII46TU/GCOLzi81E2B33BqhPVaGGD6r2vmnJubL2OFaN0c68jCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T21:50:27.544902Z"},"content_sha256":"c10af8a651bac304f44c772b8ee86d0319710136d9255485563c57be9e511242","schema_version":"1.0","event_id":"sha256:c10af8a651bac304f44c772b8ee86d0319710136d9255485563c57be9e511242"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:QRFPEQSBIUS5AETVJVF46GMRPS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Keith A. Baggerly, Kevin R. Coombes","submitted_at":"2010-10-06T08:58:16Z","abstract_excerpt":"High-throughput biological assays such as microarrays let us ask very detailed questions about how diseases operate, and promise to let us personalize therapy. Data processing, however, is often not described well enough to allow for exact reproduction of the results, leading to exercises in \"forensic bioinformatics\" where aspects of raw data and reported results are used to infer what methods must have been employed. Unfortunately, poor documentation can shift from an inconvenience to an active danger when it obscures not just methods but errors. In this report we examine several related pape"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1010.1092","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:39:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"U4iN0v0Lwurcj/+tTWkY2jnzpctX5POQyvwu/E5ieFn1Nh2m6gu3nl2dTL9Wt8fYdGZHrjRQBayw29+rb7rJBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T21:50:27.545251Z"},"content_sha256":"344a71f5c3a589730261723947774e52eda3be42821b6744c215935189c32ff5","schema_version":"1.0","event_id":"sha256:344a71f5c3a589730261723947774e52eda3be42821b6744c215935189c32ff5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QRFPEQSBIUS5AETVJVF46GMRPS/bundle.json","state_url":"https://pith.science/pith/QRFPEQSBIUS5AETVJVF46GMRPS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QRFPEQSBIUS5AETVJVF46GMRPS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T21:50:27Z","links":{"resolver":"https://pith.science/pith/QRFPEQSBIUS5AETVJVF46GMRPS","bundle":"https://pith.science/pith/QRFPEQSBIUS5AETVJVF46GMRPS/bundle.json","state":"https://pith.science/pith/QRFPEQSBIUS5AETVJVF46GMRPS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QRFPEQSBIUS5AETVJVF46GMRPS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:QRFPEQSBIUS5AETVJVF46GMRPS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"41df754ed2c1f86ca0244c679d861881a410629a4dabd4129ef7b7a608a9c5cc","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2010-10-06T08:58:16Z","title_canon_sha256":"c73969d35b10190376a650a2bd0d6da9e0b44894feca0f6e4ecefe8e5f38f5f0"},"schema_version":"1.0","source":{"id":"1010.1092","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1010.1092","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"arxiv_version","alias_value":"1010.1092v1","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1010.1092","created_at":"2026-05-18T04:39:49Z"},{"alias_kind":"pith_short_12","alias_value":"QRFPEQSBIUS5","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_16","alias_value":"QRFPEQSBIUS5AETV","created_at":"2026-05-18T12:26:12Z"},{"alias_kind":"pith_short_8","alias_value":"QRFPEQSB","created_at":"2026-05-18T12:26:12Z"}],"graph_snapshots":[{"event_id":"sha256:344a71f5c3a589730261723947774e52eda3be42821b6744c215935189c32ff5","target":"graph","created_at":"2026-05-18T04:39:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"High-throughput biological assays such as microarrays let us ask very detailed questions about how diseases operate, and promise to let us personalize therapy. Data processing, however, is often not described well enough to allow for exact reproduction of the results, leading to exercises in \"forensic bioinformatics\" where aspects of raw data and reported results are used to infer what methods must have been employed. Unfortunately, poor documentation can shift from an inconvenience to an active danger when it obscures not just methods but errors. In this report we examine several related pape","authors_text":"Keith A. Baggerly, Kevin R. Coombes","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2010-10-06T08:58:16Z","title":"Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1010.1092","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c10af8a651bac304f44c772b8ee86d0319710136d9255485563c57be9e511242","target":"record","created_at":"2026-05-18T04:39:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"41df754ed2c1f86ca0244c679d861881a410629a4dabd4129ef7b7a608a9c5cc","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2010-10-06T08:58:16Z","title_canon_sha256":"c73969d35b10190376a650a2bd0d6da9e0b44894feca0f6e4ecefe8e5f38f5f0"},"schema_version":"1.0","source":{"id":"1010.1092","kind":"arxiv","version":1}},"canonical_sha256":"844af242414525d012754d4bcf19917cbe4edb76184601293812afdc690cba5e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"844af242414525d012754d4bcf19917cbe4edb76184601293812afdc690cba5e","first_computed_at":"2026-05-18T04:39:49.848177Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:39:49.848177Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ufKOqpwYBQqc5bySHvsNojCOUfONEnPnIQbky72g6JvzWWsIzgZMRR0TzM0RX2XlRPYEGBMd+pKzSZ7xir44Dg==","signature_status":"signed_v1","signed_at":"2026-05-18T04:39:49.848594Z","signed_message":"canonical_sha256_bytes"},"source_id":"1010.1092","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c10af8a651bac304f44c772b8ee86d0319710136d9255485563c57be9e511242","sha256:344a71f5c3a589730261723947774e52eda3be42821b6744c215935189c32ff5"],"state_sha256":"df3f8d224f1499aeeff073ad47ac62d07dc0421beed99995ae7f740d7ab18f3e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EhFLm02ivX9IBtT/XEZSEoXPLa89zNlSVmKvfxMFfW7sZ3oDryII01Txo5Die449rL3V/9R/k712asFn7Ek8CA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T21:50:27.547325Z","bundle_sha256":"7d72844dc523bd958ab387cb4ce893a25bacb48db43ceee75129ca417f25184c"}}