{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:QTJBW3X55XZVK32EW4CCEDSGDU","short_pith_number":"pith:QTJBW3X5","canonical_record":{"source":{"id":"2210.00948","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-10-03T14:03:51Z","cross_cats_sorted":[],"title_canon_sha256":"d2d6fcd9775fe0bffd97e43b171f11c7eec4f1a6a5574edac04a1d6c51e8af25","abstract_canon_sha256":"576f917a90a244cacaa7a52818e53598fb1ef97bbb89117fae53a48894763053"},"schema_version":"1.0"},"canonical_sha256":"84d21b6efdedf3556f44b704220e461d0f84fe512c7188704b3068b1e9962f8a","source":{"kind":"arxiv","id":"2210.00948","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2210.00948","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"arxiv_version","alias_value":"2210.00948v1","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2210.00948","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_12","alias_value":"QTJBW3X55XZV","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_16","alias_value":"QTJBW3X55XZVK32E","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_8","alias_value":"QTJBW3X5","created_at":"2026-07-05T08:10:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:QTJBW3X55XZVK32EW4CCEDSGDU","target":"record","payload":{"canonical_record":{"source":{"id":"2210.00948","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-10-03T14:03:51Z","cross_cats_sorted":[],"title_canon_sha256":"d2d6fcd9775fe0bffd97e43b171f11c7eec4f1a6a5574edac04a1d6c51e8af25","abstract_canon_sha256":"576f917a90a244cacaa7a52818e53598fb1ef97bbb89117fae53a48894763053"},"schema_version":"1.0"},"canonical_sha256":"84d21b6efdedf3556f44b704220e461d0f84fe512c7188704b3068b1e9962f8a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:10:11.574697Z","signature_b64":"dpvpTM9nByePuIBVcpjxtQuTlhpPqzWRp4Dy54IwUwPyK3zyijTyh6ewdd88C+0L5u/dxDRrpTnAd5SITsVfAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"84d21b6efdedf3556f44b704220e461d0f84fe512c7188704b3068b1e9962f8a","last_reissued_at":"2026-07-05T08:10:11.574290Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:10:11.574290Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2210.00948","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:10:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hB2v/IFneirEEL3RBLkpMQQT48kCjVtRCPK811GTDzlE6KaEkTg1r1TX4zXEeQAVNu0Wh3YOHjNJqGNEycuABA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T21:37:15.420831Z"},"content_sha256":"a038171c16214162235cd58071df60513e33e623067774efa1e7092d37330961","schema_version":"1.0","event_id":"sha256:a038171c16214162235cd58071df60513e33e623067774efa1e7092d37330961"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:QTJBW3X55XZVK32EW4CCEDSGDU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Collective rotational motion of freely-expanding T84 epithelial cell colonies","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.soft","authors_text":"Amin Doostmohammadi, Flora Ascione, Julia M. Yeomans, Luigi Maiuri, Mehrana R. Nejad, Sergio Caserta, Speranza Esposito, Stefano Guido, Valeria Rachela Villella","submitted_at":"2022-10-03T14:03:51Z","abstract_excerpt":"Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on confined epithelial cells. The driver of collective rotation in such conditions has not been clearly elucidated, although it has been speculated that spatial confinement can play an essential role in triggering cell rotation. Here, we study the growth of epithelial cell colonies freely expanding (i.e., with no physical constraints) on the surface of cell culture plates, a ca"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2210.00948","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2210.00948/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T08:10:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sl9Axocfjq9QO3DngUqadQFMdgi2E2RgTrN/YDTi+gUbElaXp1pK5KF1EjzCNribjtzXQYpWCUURFEXxQ3YWAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T21:37:15.421712Z"},"content_sha256":"ced41353429e581b8f21c339d322020bf8d22ab56c4b85ac7321ce9154395183","schema_version":"1.0","event_id":"sha256:ced41353429e581b8f21c339d322020bf8d22ab56c4b85ac7321ce9154395183"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QTJBW3X55XZVK32EW4CCEDSGDU/bundle.json","state_url":"https://pith.science/pith/QTJBW3X55XZVK32EW4CCEDSGDU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QTJBW3X55XZVK32EW4CCEDSGDU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T21:37:15Z","links":{"resolver":"https://pith.science/pith/QTJBW3X55XZVK32EW4CCEDSGDU","bundle":"https://pith.science/pith/QTJBW3X55XZVK32EW4CCEDSGDU/bundle.json","state":"https://pith.science/pith/QTJBW3X55XZVK32EW4CCEDSGDU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QTJBW3X55XZVK32EW4CCEDSGDU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:QTJBW3X55XZVK32EW4CCEDSGDU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"576f917a90a244cacaa7a52818e53598fb1ef97bbb89117fae53a48894763053","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-10-03T14:03:51Z","title_canon_sha256":"d2d6fcd9775fe0bffd97e43b171f11c7eec4f1a6a5574edac04a1d6c51e8af25"},"schema_version":"1.0","source":{"id":"2210.00948","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2210.00948","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"arxiv_version","alias_value":"2210.00948v1","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2210.00948","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_12","alias_value":"QTJBW3X55XZV","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_16","alias_value":"QTJBW3X55XZVK32E","created_at":"2026-07-05T08:10:11Z"},{"alias_kind":"pith_short_8","alias_value":"QTJBW3X5","created_at":"2026-07-05T08:10:11Z"}],"graph_snapshots":[{"event_id":"sha256:ced41353429e581b8f21c339d322020bf8d22ab56c4b85ac7321ce9154395183","target":"graph","created_at":"2026-07-05T08:10:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2210.00948/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Coordinated rotational motion is an intriguing, yet still elusive mode of collective cell migration, which is relevant in pathological and morphogenetic processes. Most of the studies on this topic have been carried out on confined epithelial cells. The driver of collective rotation in such conditions has not been clearly elucidated, although it has been speculated that spatial confinement can play an essential role in triggering cell rotation. Here, we study the growth of epithelial cell colonies freely expanding (i.e., with no physical constraints) on the surface of cell culture plates, a ca","authors_text":"Amin Doostmohammadi, Flora Ascione, Julia M. Yeomans, Luigi Maiuri, Mehrana R. Nejad, Sergio Caserta, Speranza Esposito, Stefano Guido, Valeria Rachela Villella","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-10-03T14:03:51Z","title":"Collective rotational motion of freely-expanding T84 epithelial cell colonies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2210.00948","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a038171c16214162235cd58071df60513e33e623067774efa1e7092d37330961","target":"record","created_at":"2026-07-05T08:10:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"576f917a90a244cacaa7a52818e53598fb1ef97bbb89117fae53a48894763053","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-10-03T14:03:51Z","title_canon_sha256":"d2d6fcd9775fe0bffd97e43b171f11c7eec4f1a6a5574edac04a1d6c51e8af25"},"schema_version":"1.0","source":{"id":"2210.00948","kind":"arxiv","version":1}},"canonical_sha256":"84d21b6efdedf3556f44b704220e461d0f84fe512c7188704b3068b1e9962f8a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"84d21b6efdedf3556f44b704220e461d0f84fe512c7188704b3068b1e9962f8a","first_computed_at":"2026-07-05T08:10:11.574290Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T08:10:11.574290Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"dpvpTM9nByePuIBVcpjxtQuTlhpPqzWRp4Dy54IwUwPyK3zyijTyh6ewdd88C+0L5u/dxDRrpTnAd5SITsVfAg==","signature_status":"signed_v1","signed_at":"2026-07-05T08:10:11.574697Z","signed_message":"canonical_sha256_bytes"},"source_id":"2210.00948","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a038171c16214162235cd58071df60513e33e623067774efa1e7092d37330961","sha256:ced41353429e581b8f21c339d322020bf8d22ab56c4b85ac7321ce9154395183"],"state_sha256":"c41a0fd00e99cbca062668034b87d3947757e3a4dfbf08d2b67114d60f3ccec5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"VhNVv4mArgGLuj6+I13Dr80MAQ4n9WKVVExdpTf+CK8rd+HNnDIld9qFqFI1sfxCt+BmcCpG+Kcqeq5RMFGGDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T21:37:15.428250Z","bundle_sha256":"60b9353c7dfce1c091836531305f398983dd4efc858067d75ef951419161f24e"}}