{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:QU66RIW54XWVVZDOVSEDLVWBKU","short_pith_number":"pith:QU66RIW5","canonical_record":{"source":{"id":"1406.0148","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-06-01T09:15:41Z","cross_cats_sorted":["math.AC","math.ST","q-bio.GN","stat.TH"],"title_canon_sha256":"d9c918a456d930f4358f3cea2866648ae76674a592ab62ea19335cb49d01d898","abstract_canon_sha256":"75c60594c03f8abfbd5e0257ef8376e4f151a927baba0d25b054f073b4f2208b"},"schema_version":"1.0"},"canonical_sha256":"853de8a2dde5ed5ae46eac8835d6c1553955826166b597f22f8693d603cd62ef","source":{"kind":"arxiv","id":"1406.0148","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1406.0148","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"arxiv_version","alias_value":"1406.0148v1","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1406.0148","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"pith_short_12","alias_value":"QU66RIW54XWV","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_16","alias_value":"QU66RIW54XWVVZDO","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_8","alias_value":"QU66RIW5","created_at":"2026-05-18T12:28:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:QU66RIW54XWVVZDOVSEDLVWBKU","target":"record","payload":{"canonical_record":{"source":{"id":"1406.0148","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-06-01T09:15:41Z","cross_cats_sorted":["math.AC","math.ST","q-bio.GN","stat.TH"],"title_canon_sha256":"d9c918a456d930f4358f3cea2866648ae76674a592ab62ea19335cb49d01d898","abstract_canon_sha256":"75c60594c03f8abfbd5e0257ef8376e4f151a927baba0d25b054f073b4f2208b"},"schema_version":"1.0"},"canonical_sha256":"853de8a2dde5ed5ae46eac8835d6c1553955826166b597f22f8693d603cd62ef","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:50:41.656786Z","signature_b64":"6IIgXF2NqN/hXL2gNA3VQLRfRAld0YQkWycm4AtDiBLaMWieb/BxJyLeO/zVPFE+gxZ3IS+gJUVBD6bg+jHcAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"853de8a2dde5ed5ae46eac8835d6c1553955826166b597f22f8693d603cd62ef","last_reissued_at":"2026-05-18T02:50:41.656233Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:50:41.656233Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1406.0148","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:50:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"D+bL5jTPwfLE1RFWAeN0L+qWE+e+23vgC/iQXIQQBjApDpAXxdGDDV/PAXYg2Brm/hq6MTzAfqa3tCz6myFsAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T22:47:01.679127Z"},"content_sha256":"28845e5a680ae42662707acd0495d54b335bd9b712b2d5b6d6cc67ff22caf37f","schema_version":"1.0","event_id":"sha256:28845e5a680ae42662707acd0495d54b335bd9b712b2d5b6d6cc67ff22caf37f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:QU66RIW54XWVVZDOVSEDLVWBKU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Uncovering Proximity of Chromosome Territories using Classical Algebraic Statistics","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["math.AC","math.ST","q-bio.GN","stat.TH"],"primary_cat":"stat.AP","authors_text":"Ido Heskia, Javier Arsuaga, Serkan Hosten, Tatsiana Maskalevich","submitted_at":"2014-06-01T09:15:41Z","abstract_excerpt":"Exchange type chromosome aberrations (ETCAs) are rearrangements of the genome that occur when chromosomes break and the resulting fragments rejoin with other fragments from other chromosomes. ETCAs are commonly observed in cancer cells and in cells exposed to radiation. The frequency of these chromosome rearrangements is correlated with their spatial proximity, therefore it can be used to infer the three dimensional organization of the genome. Extracting statistical significance of spatial proximity from cancer and radiation data has remained somewhat elusive because of the sparsity of the dat"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1406.0148","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:50:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"inLfmsstlgVoxrEBHPfO+xTS0XXRSuQZXQfw6ngF0FjilnN0MTVAXgWbiZbx8EtsjxbDsyPkr733Ipnuyg8NCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T22:47:01.679500Z"},"content_sha256":"235ca663c24a185bb773f865fa507c4832b128eb985fbf1bea9781952ee36ab1","schema_version":"1.0","event_id":"sha256:235ca663c24a185bb773f865fa507c4832b128eb985fbf1bea9781952ee36ab1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QU66RIW54XWVVZDOVSEDLVWBKU/bundle.json","state_url":"https://pith.science/pith/QU66RIW54XWVVZDOVSEDLVWBKU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QU66RIW54XWVVZDOVSEDLVWBKU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T22:47:01Z","links":{"resolver":"https://pith.science/pith/QU66RIW54XWVVZDOVSEDLVWBKU","bundle":"https://pith.science/pith/QU66RIW54XWVVZDOVSEDLVWBKU/bundle.json","state":"https://pith.science/pith/QU66RIW54XWVVZDOVSEDLVWBKU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QU66RIW54XWVVZDOVSEDLVWBKU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:QU66RIW54XWVVZDOVSEDLVWBKU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"75c60594c03f8abfbd5e0257ef8376e4f151a927baba0d25b054f073b4f2208b","cross_cats_sorted":["math.AC","math.ST","q-bio.GN","stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-06-01T09:15:41Z","title_canon_sha256":"d9c918a456d930f4358f3cea2866648ae76674a592ab62ea19335cb49d01d898"},"schema_version":"1.0","source":{"id":"1406.0148","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1406.0148","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"arxiv_version","alias_value":"1406.0148v1","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1406.0148","created_at":"2026-05-18T02:50:41Z"},{"alias_kind":"pith_short_12","alias_value":"QU66RIW54XWV","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_16","alias_value":"QU66RIW54XWVVZDO","created_at":"2026-05-18T12:28:46Z"},{"alias_kind":"pith_short_8","alias_value":"QU66RIW5","created_at":"2026-05-18T12:28:46Z"}],"graph_snapshots":[{"event_id":"sha256:235ca663c24a185bb773f865fa507c4832b128eb985fbf1bea9781952ee36ab1","target":"graph","created_at":"2026-05-18T02:50:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Exchange type chromosome aberrations (ETCAs) are rearrangements of the genome that occur when chromosomes break and the resulting fragments rejoin with other fragments from other chromosomes. ETCAs are commonly observed in cancer cells and in cells exposed to radiation. The frequency of these chromosome rearrangements is correlated with their spatial proximity, therefore it can be used to infer the three dimensional organization of the genome. Extracting statistical significance of spatial proximity from cancer and radiation data has remained somewhat elusive because of the sparsity of the dat","authors_text":"Ido Heskia, Javier Arsuaga, Serkan Hosten, Tatsiana Maskalevich","cross_cats":["math.AC","math.ST","q-bio.GN","stat.TH"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-06-01T09:15:41Z","title":"Uncovering Proximity of Chromosome Territories using Classical Algebraic Statistics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1406.0148","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:28845e5a680ae42662707acd0495d54b335bd9b712b2d5b6d6cc67ff22caf37f","target":"record","created_at":"2026-05-18T02:50:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"75c60594c03f8abfbd5e0257ef8376e4f151a927baba0d25b054f073b4f2208b","cross_cats_sorted":["math.AC","math.ST","q-bio.GN","stat.TH"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2014-06-01T09:15:41Z","title_canon_sha256":"d9c918a456d930f4358f3cea2866648ae76674a592ab62ea19335cb49d01d898"},"schema_version":"1.0","source":{"id":"1406.0148","kind":"arxiv","version":1}},"canonical_sha256":"853de8a2dde5ed5ae46eac8835d6c1553955826166b597f22f8693d603cd62ef","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"853de8a2dde5ed5ae46eac8835d6c1553955826166b597f22f8693d603cd62ef","first_computed_at":"2026-05-18T02:50:41.656233Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:50:41.656233Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"6IIgXF2NqN/hXL2gNA3VQLRfRAld0YQkWycm4AtDiBLaMWieb/BxJyLeO/zVPFE+gxZ3IS+gJUVBD6bg+jHcAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:50:41.656786Z","signed_message":"canonical_sha256_bytes"},"source_id":"1406.0148","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:28845e5a680ae42662707acd0495d54b335bd9b712b2d5b6d6cc67ff22caf37f","sha256:235ca663c24a185bb773f865fa507c4832b128eb985fbf1bea9781952ee36ab1"],"state_sha256":"fa9629aa402138bb66122085c75df4185f85150d27764db8e70dc57cab9361d2"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JNsP2HVJVY+7JRAdDUwQn6zrgp2DVSzepR+o3on5dMP7bR9vlrkVwZPhnXyltmjfWFbTFCy76y5xnr8XJvilBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T22:47:01.681512Z","bundle_sha256":"05a89f68f360f83e92380da0735f9964ae6100d76f36fdd464bc2f19a7336446"}}