{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:QZRTXN7KOFGWV6QZEL77NHGDMV","short_pith_number":"pith:QZRTXN7K","canonical_record":{"source":{"id":"1703.02011","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-03-06T18:22:34Z","cross_cats_sorted":["physics.chem-ph","q-bio.QM"],"title_canon_sha256":"c43f9ff2253136fc4bb6c86a5ec37fbd9b0c3f3e4d945128a2868e263e7a7953","abstract_canon_sha256":"0fb4f9c0fdbd2868b37711cee70b73b38707f7bdbdb3b2d09db8d28752dcc119"},"schema_version":"1.0"},"canonical_sha256":"86633bb7ea714d6afa1922fff69cc3655db35de1724c67b1071b7a3ed005fb9b","source":{"kind":"arxiv","id":"1703.02011","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1703.02011","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"arxiv_version","alias_value":"1703.02011v2","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1703.02011","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"pith_short_12","alias_value":"QZRTXN7KOFGW","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_16","alias_value":"QZRTXN7KOFGWV6QZ","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_8","alias_value":"QZRTXN7K","created_at":"2026-05-18T12:31:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:QZRTXN7KOFGWV6QZEL77NHGDMV","target":"record","payload":{"canonical_record":{"source":{"id":"1703.02011","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-03-06T18:22:34Z","cross_cats_sorted":["physics.chem-ph","q-bio.QM"],"title_canon_sha256":"c43f9ff2253136fc4bb6c86a5ec37fbd9b0c3f3e4d945128a2868e263e7a7953","abstract_canon_sha256":"0fb4f9c0fdbd2868b37711cee70b73b38707f7bdbdb3b2d09db8d28752dcc119"},"schema_version":"1.0"},"canonical_sha256":"86633bb7ea714d6afa1922fff69cc3655db35de1724c67b1071b7a3ed005fb9b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:44:23.368458Z","signature_b64":"4VMWJ3bwYeuK9Mndfpnky7y2Ok8ODYveJwp12ji5JV3NmtZuYmugxUGhfGLrEdl7YZ+/RpdJL5oKHfxpSJ9zAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"86633bb7ea714d6afa1922fff69cc3655db35de1724c67b1071b7a3ed005fb9b","last_reissued_at":"2026-05-18T00:44:23.368032Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:44:23.368032Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1703.02011","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:44:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"95H5CLGhJlAJU92136ABf2P7NPWr9YQG+uKMFzuDxAtUjc903VZ/CHDYa8Xs8uyRHicIoNc0rA1XeSGrbHXaDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T13:09:53.863593Z"},"content_sha256":"efdfa28ffd8e8b2f22f90fc4cf6e4a907f302cc0d7dfbf52fdb16af5276fe41c","schema_version":"1.0","event_id":"sha256:efdfa28ffd8e8b2f22f90fc4cf6e4a907f302cc0d7dfbf52fdb16af5276fe41c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:QZRTXN7KOFGWV6QZEL77NHGDMV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Conformational Nonequilibrium Enzyme Kinetics: Generalized Michaelis-Menten Equation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.QM"],"primary_cat":"physics.bio-ph","authors_text":"D. Evan Piephoff, Jianlan Wu, Jianshu Cao","submitted_at":"2017-03-06T18:22:34Z","abstract_excerpt":"In a conformational nonequilibrium steady state (cNESS), enzyme turnover is modulated by the underlying conformational dynamics. Based on a discrete kinetic network model, we use the integrated probability flux balance method to derive the cNESS turnover rate for a conformation-modulated enzymatic reaction. The traditional Michaelis-Menten (MM) rate equation is extended to a generalized form, which includes non-MM corrections induced by conformational population currents within combined cyclic kinetic loops. When conformational detailed balance is satisfied, the turnover rate reduces to the MM"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1703.02011","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:44:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Lc/JoffaEgdbm3anK2bxFY8n/ww/xaRKDGUimTwTdohALSeTsyL3U5xhCKc+XOf1D1JTN11c9lMYszi2B0a8DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T13:09:53.863938Z"},"content_sha256":"33c00908cb9f0b0b734a5d998129958d6403e55290a9d3cca9cb471fc452000c","schema_version":"1.0","event_id":"sha256:33c00908cb9f0b0b734a5d998129958d6403e55290a9d3cca9cb471fc452000c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/bundle.json","state_url":"https://pith.science/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T13:09:53Z","links":{"resolver":"https://pith.science/pith/QZRTXN7KOFGWV6QZEL77NHGDMV","bundle":"https://pith.science/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/bundle.json","state":"https://pith.science/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/QZRTXN7KOFGWV6QZEL77NHGDMV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:QZRTXN7KOFGWV6QZEL77NHGDMV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0fb4f9c0fdbd2868b37711cee70b73b38707f7bdbdb3b2d09db8d28752dcc119","cross_cats_sorted":["physics.chem-ph","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-03-06T18:22:34Z","title_canon_sha256":"c43f9ff2253136fc4bb6c86a5ec37fbd9b0c3f3e4d945128a2868e263e7a7953"},"schema_version":"1.0","source":{"id":"1703.02011","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1703.02011","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"arxiv_version","alias_value":"1703.02011v2","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1703.02011","created_at":"2026-05-18T00:44:23Z"},{"alias_kind":"pith_short_12","alias_value":"QZRTXN7KOFGW","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_16","alias_value":"QZRTXN7KOFGWV6QZ","created_at":"2026-05-18T12:31:39Z"},{"alias_kind":"pith_short_8","alias_value":"QZRTXN7K","created_at":"2026-05-18T12:31:39Z"}],"graph_snapshots":[{"event_id":"sha256:33c00908cb9f0b0b734a5d998129958d6403e55290a9d3cca9cb471fc452000c","target":"graph","created_at":"2026-05-18T00:44:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In a conformational nonequilibrium steady state (cNESS), enzyme turnover is modulated by the underlying conformational dynamics. Based on a discrete kinetic network model, we use the integrated probability flux balance method to derive the cNESS turnover rate for a conformation-modulated enzymatic reaction. The traditional Michaelis-Menten (MM) rate equation is extended to a generalized form, which includes non-MM corrections induced by conformational population currents within combined cyclic kinetic loops. When conformational detailed balance is satisfied, the turnover rate reduces to the MM","authors_text":"D. Evan Piephoff, Jianlan Wu, Jianshu Cao","cross_cats":["physics.chem-ph","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-03-06T18:22:34Z","title":"Conformational Nonequilibrium Enzyme Kinetics: Generalized Michaelis-Menten Equation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1703.02011","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:efdfa28ffd8e8b2f22f90fc4cf6e4a907f302cc0d7dfbf52fdb16af5276fe41c","target":"record","created_at":"2026-05-18T00:44:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0fb4f9c0fdbd2868b37711cee70b73b38707f7bdbdb3b2d09db8d28752dcc119","cross_cats_sorted":["physics.chem-ph","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-03-06T18:22:34Z","title_canon_sha256":"c43f9ff2253136fc4bb6c86a5ec37fbd9b0c3f3e4d945128a2868e263e7a7953"},"schema_version":"1.0","source":{"id":"1703.02011","kind":"arxiv","version":2}},"canonical_sha256":"86633bb7ea714d6afa1922fff69cc3655db35de1724c67b1071b7a3ed005fb9b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"86633bb7ea714d6afa1922fff69cc3655db35de1724c67b1071b7a3ed005fb9b","first_computed_at":"2026-05-18T00:44:23.368032Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:44:23.368032Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"4VMWJ3bwYeuK9Mndfpnky7y2Ok8ODYveJwp12ji5JV3NmtZuYmugxUGhfGLrEdl7YZ+/RpdJL5oKHfxpSJ9zAg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:44:23.368458Z","signed_message":"canonical_sha256_bytes"},"source_id":"1703.02011","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:efdfa28ffd8e8b2f22f90fc4cf6e4a907f302cc0d7dfbf52fdb16af5276fe41c","sha256:33c00908cb9f0b0b734a5d998129958d6403e55290a9d3cca9cb471fc452000c"],"state_sha256":"a75690113779d3aced5af1c22b80469e56f648946c83a99618f65c82a3929951"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"S1xfzBrraZwFmqHubK41vSRzTgsF3+bj6LJ2wUwyo+6tmtNC60ayxma3YTR0XYcqNIyJpfapiSeWNk0rsYesAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T13:09:53.865873Z","bundle_sha256":"3e60512863e0246c7615b0b42893d7e64f658af3a08fac28178c423cff0433b0"}}