{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:R3YRDV34YFW3I4LO47GHRVBAWJ","short_pith_number":"pith:R3YRDV34","canonical_record":{"source":{"id":"1805.04287","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-05-11T09:17:25Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"811802a63cc529d3eeb12007ce7ba5efe484f4bcc5c8f30acb47dc1f7ebb341c","abstract_canon_sha256":"5edc5a303e5e9268e00c3c4b1ac5e1cd4313832a0ebc95cee24ed78ed816ea06"},"schema_version":"1.0"},"canonical_sha256":"8ef111d77cc16db4716ee7cc78d420b2503d7a979e7bbd579db861674b3a79fb","source":{"kind":"arxiv","id":"1805.04287","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.04287","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"arxiv_version","alias_value":"1805.04287v1","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.04287","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"pith_short_12","alias_value":"R3YRDV34YFW3","created_at":"2026-05-18T12:32:50Z"},{"alias_kind":"pith_short_16","alias_value":"R3YRDV34YFW3I4LO","created_at":"2026-05-18T12:32:50Z"},{"alias_kind":"pith_short_8","alias_value":"R3YRDV34","created_at":"2026-05-18T12:32:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:R3YRDV34YFW3I4LO47GHRVBAWJ","target":"record","payload":{"canonical_record":{"source":{"id":"1805.04287","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-05-11T09:17:25Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"811802a63cc529d3eeb12007ce7ba5efe484f4bcc5c8f30acb47dc1f7ebb341c","abstract_canon_sha256":"5edc5a303e5e9268e00c3c4b1ac5e1cd4313832a0ebc95cee24ed78ed816ea06"},"schema_version":"1.0"},"canonical_sha256":"8ef111d77cc16db4716ee7cc78d420b2503d7a979e7bbd579db861674b3a79fb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:16:12.936548Z","signature_b64":"VbNlPvv9xAP73HmjPJ0Voq9wSP2vjB2XzUEclnkBN3ZqSlGgz5slyOwMmPvoByaGIUqXNKwEfB7z1bYbpdMLCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"8ef111d77cc16db4716ee7cc78d420b2503d7a979e7bbd579db861674b3a79fb","last_reissued_at":"2026-05-18T00:16:12.934562Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:16:12.934562Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1805.04287","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:16:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5Jz8KEdvSau2izEzLR8TKDcXJV4QBIP97AK2ztMBhZOHBFtutzIzWixVDamjpWra3+N2WtIktojE3nehDcjMAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T19:08:18.489500Z"},"content_sha256":"2917e5b9b0c60a9d20384485b35342f1470dd8eebc4088b661fbed92bf166938","schema_version":"1.0","event_id":"sha256:2917e5b9b0c60a9d20384485b35342f1470dd8eebc4088b661fbed92bf166938"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:R3YRDV34YFW3I4LO47GHRVBAWJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Control of DNA denaturation bubble nucleation to advance nano-biosensing","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft"],"primary_cat":"physics.bio-ph","authors_text":"Catherine Tardin, Fran\\c{c}ois Sicard, Manoel Manghi, Nicolas Destainville, Philippe Rousseau","submitted_at":"2018-05-11T09:17:25Z","abstract_excerpt":"In the demanding biosensing environment, improving selection efficiency strategies has become an issue of great significance. DNA minicircles containing between 200 and 400 base-pairs, also named microDNA, are representative of the supercoiled DNA loops found in nature. Their short size makes them extremely susceptible to writhe and twist, which is known to play a central role in DNA denaturation. We investigate minicircle lengths and superhelical densities that induce DNA denaturation bubbles of nanometer size and control well-defined long-life. Mesoscopic modeling and accelerated dynamics si"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.04287","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:16:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HJ9CCitwtxYfbxcu6erogU8r4g3M/F0TrY0PJACFQXJdw1oSs6FjL/RRByUe5mxE8tBSO3242ozOT4lOX1D1AA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T19:08:18.490165Z"},"content_sha256":"dc77160d361dc04abd6f683c11bdfb718685fd1af65422ee298c2d5c37c80794","schema_version":"1.0","event_id":"sha256:dc77160d361dc04abd6f683c11bdfb718685fd1af65422ee298c2d5c37c80794"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/bundle.json","state_url":"https://pith.science/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T19:08:18Z","links":{"resolver":"https://pith.science/pith/R3YRDV34YFW3I4LO47GHRVBAWJ","bundle":"https://pith.science/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/bundle.json","state":"https://pith.science/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/R3YRDV34YFW3I4LO47GHRVBAWJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:R3YRDV34YFW3I4LO47GHRVBAWJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5edc5a303e5e9268e00c3c4b1ac5e1cd4313832a0ebc95cee24ed78ed816ea06","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-05-11T09:17:25Z","title_canon_sha256":"811802a63cc529d3eeb12007ce7ba5efe484f4bcc5c8f30acb47dc1f7ebb341c"},"schema_version":"1.0","source":{"id":"1805.04287","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1805.04287","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"arxiv_version","alias_value":"1805.04287v1","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1805.04287","created_at":"2026-05-18T00:16:12Z"},{"alias_kind":"pith_short_12","alias_value":"R3YRDV34YFW3","created_at":"2026-05-18T12:32:50Z"},{"alias_kind":"pith_short_16","alias_value":"R3YRDV34YFW3I4LO","created_at":"2026-05-18T12:32:50Z"},{"alias_kind":"pith_short_8","alias_value":"R3YRDV34","created_at":"2026-05-18T12:32:50Z"}],"graph_snapshots":[{"event_id":"sha256:dc77160d361dc04abd6f683c11bdfb718685fd1af65422ee298c2d5c37c80794","target":"graph","created_at":"2026-05-18T00:16:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In the demanding biosensing environment, improving selection efficiency strategies has become an issue of great significance. DNA minicircles containing between 200 and 400 base-pairs, also named microDNA, are representative of the supercoiled DNA loops found in nature. Their short size makes them extremely susceptible to writhe and twist, which is known to play a central role in DNA denaturation. We investigate minicircle lengths and superhelical densities that induce DNA denaturation bubbles of nanometer size and control well-defined long-life. Mesoscopic modeling and accelerated dynamics si","authors_text":"Catherine Tardin, Fran\\c{c}ois Sicard, Manoel Manghi, Nicolas Destainville, Philippe Rousseau","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-05-11T09:17:25Z","title":"Control of DNA denaturation bubble nucleation to advance nano-biosensing"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1805.04287","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2917e5b9b0c60a9d20384485b35342f1470dd8eebc4088b661fbed92bf166938","target":"record","created_at":"2026-05-18T00:16:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5edc5a303e5e9268e00c3c4b1ac5e1cd4313832a0ebc95cee24ed78ed816ea06","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-05-11T09:17:25Z","title_canon_sha256":"811802a63cc529d3eeb12007ce7ba5efe484f4bcc5c8f30acb47dc1f7ebb341c"},"schema_version":"1.0","source":{"id":"1805.04287","kind":"arxiv","version":1}},"canonical_sha256":"8ef111d77cc16db4716ee7cc78d420b2503d7a979e7bbd579db861674b3a79fb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"8ef111d77cc16db4716ee7cc78d420b2503d7a979e7bbd579db861674b3a79fb","first_computed_at":"2026-05-18T00:16:12.934562Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:16:12.934562Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VbNlPvv9xAP73HmjPJ0Voq9wSP2vjB2XzUEclnkBN3ZqSlGgz5slyOwMmPvoByaGIUqXNKwEfB7z1bYbpdMLCw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:16:12.936548Z","signed_message":"canonical_sha256_bytes"},"source_id":"1805.04287","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2917e5b9b0c60a9d20384485b35342f1470dd8eebc4088b661fbed92bf166938","sha256:dc77160d361dc04abd6f683c11bdfb718685fd1af65422ee298c2d5c37c80794"],"state_sha256":"ed535cecf391faf76bc789cecf77e324ee77dba63fd09ee601725354512db12d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OODJ3vjYvRgURIvR+F8mkYqGmyO/vwGLioFITHKM25OAaVOzcxOVAB+BsOjKH2kJ+0yIWGO7yaPrc/BTbH80DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T19:08:18.493868Z","bundle_sha256":"37b76beece18e4faa6be6f0735a640c920202b91dede5bc5a6778e9b34dc84ae"}}